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anti-KPNa2 antibody :: Rabbit anti-Human Karyopherin Alpha 2 (KPNa2) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2005941 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $225 +1 FREE 8GB USB
0.2 mg  /  $340 +1 FREE 8GB USB
1 mg  /  $800 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Karyopherin Alpha 2 (KPNa2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Karyopherin Alpha 2 (KPNa2)

 Product Gene Name   

anti-KPNa2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- AVVD GGAIPAFISL LASPHAHISE QAVWALGNIA GDGSVFRDLV IKYGAVDPLL ALLAVPDMSS LACGYLRNLT WTLSNLCRNK NPAPPIDAVE QILPTLVRLL HHDDPEVLAD TCWAISYLTD GPNERIGMVV KTGVVPQLVK LLGASELPIV TPALRAIGNI VTGTDEQTQV VIDAGALAVF PSLLTNPKTN IQKEATWTMS NITAGRQDQI QQVVNHGLVP FLVSVLSKAD FKTQKEAVWA VTNYTSGGTV EQ
 OMIM    U28386 mRNA
 3D Structure    ModBase 3D Structure for P52292
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against KPNa2. It has been selected for its ability to recognize KPNa2 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Recombinant KPNa2 (Ala157~Gln412) expressed in E.coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2075229
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-KPNa2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-KPNa2 antibody    Knock-Out Validation Antibody
 Applications Tested/Suitable for anti-KPNa2 antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-KPNa2 antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) Knockout Verification of anti-KPNa2 antibody    Knockout Verification: Lane 1: Wild-type HepG2 cell lysate
Lane 2: KPNa2 knockout HepG2 cell lysate
Predicted MW: 58kDa ;Observed MW: 58kDa;Primary Ab: 3ug/ml Rabbit Anti-Human KPNa2 Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;
anti-KPNa2 antibody Western Blot (WB) Knockout Verification (WB) image
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 Western Blot (WB) of anti-KPNa2 antibody    Western Blot; Lane1: Human HepG2 Cells; Lane2: Human 293T Cells; Lane3: Human Raji Cells.
anti-KPNa2 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-KPNa2 antibody    Western Blot; Sample: Recombinant KPNa2, Human.
anti-KPNa2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-KPNa2 antibody    DAB staining on IHC-P. Samples: Human Tissue)
anti-KPNa2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for KPNa2. It may not necessarily be applicable to this product.
 NCBI GI #    1002341781
 NCBI GeneID    3838
 NCBI Accession #    NP_001307540.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001320611.1 [Other Products]
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 UniProt Primary Accession #    P52292 [Other Products]
 UniProt Secondary Accession #    Q53YE3; Q6NVW7; Q9BRU5; B9EJD6 [Other Products]
 UniProt Related Accession #    P52292 [Other Products]
 Molecular Weight    57,862 Da
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 NCBI Official Full Name    importin subunit alpha-1
 NCBI Official Synonym Full Names    karyopherin subunit alpha 2
 NCBI Official Symbol    KPNA2 [Similar Products]
 NCBI Official Synonym Symbols   
QIP2; RCH1; IPOA1; SRP1alpha; SRP1-alpha
[Similar Products]
 NCBI Protein Information    importin subunit alpha-1
 UniProt Protein Name    Importin subunit alpha-1
 UniProt Synonym Protein Names   
Karyopherin subunit alpha-2; RAG cohort protein 1; SRP1-alpha
 UniProt Gene Name    KPNA2 [Similar Products]
 UniProt Synonym Gene Names    RCH1; SRP1 [Similar Products]
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 NCBI Summary for KPNa2    The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
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 UniProt Comments for KPNa2    KPNA2: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the importin alpha family.

Protein type: Karyopherin; Nuclear import; Nucleoporin

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: cytoplasm; cytosol; membrane; nuclear pore; nucleoplasm

Molecular Function: histone deacetylase binding; nuclear localization sequence binding; protein binding; protein transporter activity; RNA binding

Biological Process: DNA metabolic process; modulation by virus of host process; NLS-bearing substrate import into nucleus; regulation of DNA recombination
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 Research Articles on KPNa2    1. KPNA2 was associated with tumorigenesis and cancer progression in CRC cells; high KPNA2 expression was associated with increased cell proliferation, migration, invasion, and semisolid agar colony formation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KPNa2 antibodyPathways associated with anti-KPNa2 antibody
 Reference Product  PubMed Publications
 KPNB1 antibody  >15 publications with KPNa2 and KPNB1
 NUP62 antibody  >1 publications with KPNa2 and NUP62
 RANBP2 antibody  >1 publications with KPNa2 and RANBP2
 NUP153 antibody  >1 publications with KPNa2 and NUP153
 Products by Pathway  Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DNA Double Strand Break Response Pathway antibodies  DNA Double Strand Break Response Pathway Diagram
 DNA Double-Strand Break Repair Pathway antibodies  DNA Double-Strand Break Repair Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Host Interactions With Influenza Factors Pathway antibodies  Host Interactions With Influenza Factors Pathway Diagram
 ISG15 Antiviral Mechanism Pathway antibodies  ISG15 Antiviral Mechanism Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Infectious Disease Pathway antibodies  Infectious Disease Pathway Diagram
Diseases associated with anti-KPNa2 antibodyOrgans/Tissues associated with anti-KPNa2 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >24 publications with KPNa2 and Carcinoma
 Breast Neoplasms Antibodies  >17 publications with KPNa2 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >11 publications with KPNa2 and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >10 publications with KPNa2 and Adenocarcinoma
 Ovarian Neoplasms Antibodies  >7 publications with KPNa2 and Ovarian Neoplasms
 Carcinoma, Squamous Cell Antibodies  >7 publications with KPNa2 and Carcinoma, Squamous Cell
 Lung Neoplasms Antibodies  >6 publications with KPNa2 and Lung Neoplasms
 Inflammation Antibodies  >6 publications with KPNa2 and Inflammation
 Nervous System Diseases Antibodies  >4 publications with KPNa2 and Nervous System Diseases
 Liver Neoplasms Antibodies  >4 publications with KPNa2 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >9 publications with KPNa2 and Lung
 Liver Antibodies  >7 publications with KPNa2 and Liver
 Lymph Node Antibodies  >7 publications with KPNa2 and Lymph Node
 Lymph Antibodies  >7 publications with KPNa2 and Lymph
 Prostate Antibodies  >7 publications with KPNa2 and Prostate
 Brain Antibodies  >6 publications with KPNa2 and Brain
 Blood Antibodies  >5 publications with KPNa2 and Blood
 Bladder Antibodies  >5 publications with KPNa2 and Bladder
 Muscle Antibodies  >5 publications with KPNa2 and Muscle
 Heart Antibodies  >4 publications with KPNa2 and Heart
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