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anti-KPNa2 antibody :: Rabbit anti-Human Karyopherin Alpha 2 (KPNa2) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2015280 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
SDS-PAGE
Unit / Price
0.1 mg  /  $260 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Karyopherin Alpha 2 (KPNa2), Polyclonal Antibody

★Popular Item★
 Also Known As   

FITC-linked Antibody to Karyopherin Alpha 2 (KPNa2)

 Product Gene Name   

anti-KPNa2 antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: Karyopherin Alpha 2 (KPNa2) (MBS2005941)
FITC Conjugated Antibody: Karyopherin Alpha 2 (KPNa2) (MBS2015280)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (66031848..66042970). Location: 17q24.2
 OMIM    600685
 3D Structure    ModBase 3D Structure for P52292
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against KPNa2. It has been selected for its ability to recognize KPNa2 in immunohistochemical staining and western blotting.
 Purity/Purification    Affinity Chromatography.
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
 Concentration    100 ug/mL (lot specific)
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 Immunogen    KPNa2, Human
 Immunogen Information    Recombinant KPNa2 (Ala157~Gln412) with two N-terminal Tags, His-tag and T7-tag expressed in E.coli.
  Accession No.    RPE748Hu01
 UOM    100ug
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-KPNa2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-KPNa2 antibody    FITC Antibody
 Applications Tested/Suitable for anti-KPNa2 antibody   

Immunohistochemistry-Paraffin/Frozen (IHC-P/F), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB)

 Application Notes for anti-KPNa2 antibody    Western blotting: 1:50-400
Immunocytochemistry in formalin fixed cells: 1:50-500
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Immunohistochemistry in paraffin section: 1:10-100
Enzyme-linked Immunosorbent Assay: 1:100-200
Optimal working dilutions must be determined by end user.
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 SDS-PAGE of anti-KPNa2 antibody    anti-KPNa2 antibody SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for KPNa2. It may not necessarily be applicable to this product.
 NCBI GI #    15865453
 NCBI GeneID    3838
 NCBI Accession #    CAC83080.1 [Other Products]
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 UniProt Primary Accession #    P52292 [Other Products]
 UniProt Secondary Accession #    Q53YE3; Q9BRU5; B9EJD6 [Other Products]
 UniProt Related Accession #    P52292 [Other Products]
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 NCBI Official Full Name    karyopherin alpha 2
 NCBI Official Synonym Full Names    karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
 NCBI Official Symbol    KPNA2 [Similar Products]
 NCBI Official Synonym Symbols   
QIP2; RCH1; IPOA1; SRP1alpha
[Similar Products]
 NCBI Protein Information    importin subunit alpha-1; pendulin; SRP1-alpha; RAG cohort 1; importin alpha 1; importin alpha 2; importin-alpha-P1; RAG cohort protein 1; importin subunit alpha-2; karyopherin subunit alpha-2
 UniProt Protein Name    Importin subunit alpha-1
 UniProt Synonym Protein Names   
Karyopherin subunit alpha-2; RAG cohort protein 1; SRP1-alpha
 UniProt Gene Name    KPNA2 [Similar Products]
 UniProt Synonym Gene Names    RCH1; SRP1 [Similar Products]
 UniProt Entry Name    IMA1_HUMAN
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 NCBI Summary for KPNa2    The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq, Jul 2008]
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 UniProt Comments for KPNa2    KPNA2: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the importin alpha family.

Protein type: Nuclear import; Karyopherin; Nucleoporin

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: nucleoplasm; membrane; cytoplasm; cytosol

Molecular Function: protein binding; histone deacetylase binding; nuclear localization sequence binding; protein transporter activity

Biological Process: viral reproduction; cytokine and chemokine mediated signaling pathway; regulation of DNA recombination; NLS-bearing substrate import into nucleus; DNA metabolic process
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 Research Articles on KPNa2    1. This work defines an inflammatory signature shared by seven epithelial cancer types and KPNA2 as a consistently up-regulated protein in cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KPNa2 antibodyPathways associated with anti-KPNa2 antibody
 Reference Product  PubMed Publications
 KPNB1 antibody  >8 publications with KPNa2 and KPNB1
 CDC20 antibody  >3 publications with KPNa2 and CDC20
 CCNB1 antibody  >3 publications with KPNa2 and CCNB1
 BRCA1 antibody  >2 publications with KPNa2 and BRCA1
 MAD2L1 antibody  >1 publications with KPNa2 and MAD2L1
 Products by Pathway  Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 ISG15 Antiviral Mechanism Pathway antibodies  ISG15 Antiviral Mechanism Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Regulation Of Cytoplasmic And Nuclear SMAD2/3 Signaling Pathway antibodies  Regulation Of Cytoplasmic And Nuclear SMAD2/3 Signaling Pathway Diagram
 Role Of Calcineurin-dependent NFAT Signaling In Lymphocytes Pathway antibodies  Role Of Calcineurin-dependent NFAT Signaling In Lymphocytes Pathway Diagram
 Signaling Events Mediated By TCPTP Pathway antibodies  Signaling Events Mediated By TCPTP Pathway Diagram
Diseases associated with anti-KPNa2 antibodyOrgans/Tissues associated with anti-KPNa2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >26 publications with KPNa2 and Neoplasms
 Carcinoma Antibodies  >11 publications with KPNa2 and Carcinoma
 Breast Neoplasms Antibodies  >10 publications with KPNa2 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >6 publications with KPNa2 and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >6 publications with KPNa2 and Adenocarcinoma
 Ovarian Neoplasms Antibodies  >5 publications with KPNa2 and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >4 publications with KPNa2 and Neoplasms, Experimental
 Carcinoma, Squamous Cell Antibodies  >3 publications with KPNa2 and Carcinoma, Squamous Cell
 Prostatic Neoplasms Antibodies  >3 publications with KPNa2 and Prostatic Neoplasms
 Urinary Bladder Neoplasms Antibodies  >2 publications with KPNa2 and Urinary Bladder Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >6 publications with KPNa2 and Lymph Node
 Lymph Antibodies  >6 publications with KPNa2 and Lymph
 Prostate Antibodies  >6 publications with KPNa2 and Prostate
 Lung Antibodies  >5 publications with KPNa2 and Lung
 Muscle Antibodies  >4 publications with KPNa2 and Muscle
 Embryonic Tissue Antibodies  >3 publications with KPNa2 and Embryonic Tissue
 Heart Antibodies  >3 publications with KPNa2 and Heart
 Kidney Antibodies  >2 publications with KPNa2 and Kidney
 Liver Antibodies  >2 publications with KPNa2 and Liver
 Stomach Antibodies  >2 publications with KPNa2 and Stomach
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