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anti-KNG1 antibody :: Sheep Kininogen Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS512194 anti-KNG1 antibody
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 Product Name   

Kininogen (KNG1), Polyclonal Antibody

 Also Known As   

Sheep anti-human Kininogen (KN), Peroxidase Conjugated Affinity Purified IgG

 Product Synonym Names    Kininogen
 Product Gene Name   

anti-KNG1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (186435098..186462199). Location: 3q27
 OMIM    228960
 3D Structure    ModBase 3D Structure for P01042
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 Clonality    Polyclonal
 Host    Sheep
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 Specificity    Prior to conjugation, this antibody was specific for kininogen as demonstrated by immunoelectrophoresis and ELISA.
 Purity/Purification    Affinity purified, peroxidase conj. IgG.
Vial containing ml of affinity purified IgG conjugated to horseradish peroxidase (HRP) through carbohydrate groups. Total protein is 0.1 mg.
 Form/Format    APIgG-HRP conjugate as a clear, slightly red-brown liquid.
 Concentration    APIgG-HRP concentration is mg/ml, determined by absorbance using an extinction coefficient (E1%280) of 14. (lot specific)
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 Immunogen    High molecular weight kininogen from human plasma.
 Buffer    A buffered stabilizer solution containing 50% (v/v) glycerol.
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 Preparation and Storage    Store between -10 and -20 degree C. Product will become viscous but will not freeze. Avoid storage in frost-free freezers. Keep vial tightly capped. Allow product to warm to room temperature and gently mix before use. Avoid exposure to sodium azide as this is an inhibitor of peroxidase activity.
 Other Notes    Small volumes of anti-KNG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-KNG1 antibody

   Kininogens are multi-function proteins that are involved in the processes of coagulation, anticoagulation, fibrinolysis, inflammation and cell adhesion. Kininogens are produced in the liver but have also been found in platelets, granulocytes, renal tubular cells and skin. Two forms of kininogen are identified in plasma, both of which are the result of differential splicing of a single gene. High molecular weight kininogen (HK), previously known as Fitzgerald Factor, is a single chain glycoprotein of 120 kDa with a plasma concentration of 80 ug/mL (660 nM). Low molecular weight kininogen (LK), also known as alpha-cysteine protease inhibitor, is a single chain glycoprotein of 68 kDa with a plasma concentration of 160 ug/mL (2.35 uM). HK and LK share a common heavy chain and bradykinin domain, but have unique light chains. It is the light chain of HK that is responsible for the coagulant cofactor activity by binding to anionic surfaces and for the ability to bind the zymogens prekallikrein (PK) and factor XI (FXI). HK is cleaved by kallikrein in several sequential steps that result in the release of a potent vasodilator bradykinin and the conversion to a two-chain form of HK with increased cofactor activity. In plasma, most of the PK and FXI circulate in complex with HK. Activation of PK by FXIIa generates kallikrein, which initiates reciprocal activation of PK and FXI. The presence of HK also serves to protect kallikrein and activated FXI from protease inhibitors such as C1-Inhibitor, but regulation of the system may be accomplished through proteolytic inactivation of the HK cofactor activity by these enzymes.1-2
 Application Notes for anti-KNG1 antibody    Suitable as a source of peroxidase labeled antibodies to human kininogen.
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NCBI/Uniprot data below describe general gene information for KNG1. It may not necessarily be applicable to this product.
 NCBI GI #    386853
 NCBI GeneID    3827
 NCBI Accession #    AAB59551.1 [Other Products]
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 UniProt Primary Accession #    P01042 [Other Products]
 UniProt Secondary Accession #    P01043; Q53EQ0; Q6PAU9; Q7M4P1; A8K474; B2RCR2; C9JEX1 [Other Products]
 UniProt Related Accession #    P01042 [Other Products]
 Molecular Weight    71,957 Da [Similar Products]
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 NCBI Official Full Name    kininogen
 NCBI Official Synonym Full Names    kininogen 1
 NCBI Official Symbol    KNG1 [Similar Products]
 NCBI Official Synonym Symbols   
BK; BDK; KNG
[Similar Products]
 NCBI Protein Information    kininogen-1; HMWK; bradykinin; fitzgerald factor; high molecular weight kininogen; alpha-2-thiol proteinase inhibitor; williams-Fitzgerald-Flaujeac factor
 UniProt Protein Name    Kininogen-1
 UniProt Synonym Protein Names   
Alpha-2-thiol proteinase inhibitor; Fitzgerald factor; High molecular weight kininogen; HMWK; Williams-Fitzgerald-Flaujeac factorCleaved into the following 6 chains:Kininogen-1 heavy chainT-kinin; Alternative name(s):; Ile-Ser-BradykininBradykinin; Alternative name(s):; Kallidin ILysyl-bradykinin; Alternative name(s):; Kallidin II
 Protein Family    Kininogen
 UniProt Gene Name    KNG1 [Similar Products]
 UniProt Synonym Gene Names    BDK; KNG; HMWK [Similar Products]
 UniProt Entry Name    KNG1_HUMAN
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 NCBI Summary for KNG1    This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
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 UniProt Comments for KNG1    Function: 1 Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Subcellular location: Secreted › extracellular space.

Tissue specificity: Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors. Ref.11

Post-translational modification: Bradykinin is released from kininogen by plasma kallikrein.Hydroxylation of Pro-383 occurs prior to the release of bradykinin.Phosphorylation sites are present in the extracellular medium.N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. Ref.9 Ref.19

Polymorphism: The T-kinin peptide is missing residues 378 to 380, probably as a result of a naturally occurring variant. The complete sequence of the T-kinin peptide is therefore ISRPPGFSPFR. This peptide is associated with malignant tumors but not with benign ones.

Involvement in disease: High molecular weight kininogen deficiency (HMWK deficiency) [MIM:228960]: Autosomal recessive coagulation defect. Patients with HWMK deficiency do not have a hemorrhagic tendency, but they exhibit abnormal surface-mediated activation of fibrinolysis.Note: The disease is caused by mutations affecting the gene represented in this entry.

Sequence similarities: Contains 3 cystatin kininogen-type domains.
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Product References and Citations for anti-KNG1 antibody

   1. Coleman RW, Schmaier AH; Contact System: A Vascular Biology Modulator With Anticoagulant, Profibrinolytic, Antiadhesive and Proinflammatory Attributes. Blood 90, pp 3819-3843, 1997.
2. DeLa Cadena R, Watchtfogel YT, Colman RW, in Hemostasis and Thrombosis, 3rd Edition, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp. 219-240, J.B. Lippincott Co., Philadelphia, 1994.
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 Research Articles on KNG1    1. these results suggest that D5(H) of high molecular weight kininogen may modulate cell adhesion and invasion together with actinin-4.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KNG1 antibodyPathways associated with anti-KNG1 antibody
 Reference Product  PubMed Publications
 F12 antibody  >3 publications with KNG1 and F12
 BDKRB2 antibody  >2 publications with KNG1 and BDKRB2
 KLKB1 antibody  >1 publications with KNG1 and KLKB1
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
Diseases associated with anti-KNG1 antibodyOrgans/Tissues associated with anti-KNG1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >8 publications with KNG1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >4 publications with KNG1 and Heart Diseases
 Thrombosis Antibodies  >4 publications with KNG1 and Thrombosis
 Atherosclerosis Antibodies  >2 publications with KNG1 and Atherosclerosis
 Carcinoma, Hepatocellular Antibodies  >1 publications with KNG1 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >1 publications with KNG1 and Kidney Diseases
 Inflammation Antibodies  >1 publications with KNG1 and Inflammation
 Hypertension Antibodies  >1 publications with KNG1 and Hypertension
 Arrhythmias, Cardiac Antibodies  >1 publications with KNG1 and Arrhythmias, Cardiac
 Edema Antibodies  >1 publications with KNG1 and Edema
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with KNG1 and Brain
 Liver Antibodies  >1 publications with KNG1 and Liver
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