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anti-KCNJ11 antibody :: Kir6.2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8200907
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Kir6.2 (KCNJ11), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-Kir6.2 Antibody

 Product Synonym Names    ATP-sensitive inward rectifier potassium channel 11; IKATP; Inward rectifier K(+) channel Kir6.2; Potassium channel, inwardly rectifying subfamily J member 11
 Product Gene Name   

anti-KCNJ11 antibody

[Similar Products]
 Antibody/Peptide Pairs    Kir6.2 peptide (MBS8227035) is used for blocking the activity of Kir6.2 antibody (MBS8200907)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600937
 3D Structure    ModBase 3D Structure for Q14654
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 Clonality    Polyclonal
 Species Reactivity    Human, Mouse, Rat, Bovine, Porcine, Rabbit
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 Specificity    Recognizes endogenous levels of Kir6.2 protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Source    Rabbit
 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Kir6.2. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-KCNJ11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KCNJ11 antibody

   Rabbit polyclonal antibody to Kir6.2
 Applications Tested/Suitable for anti-KCNJ11 antibody   

Western Blot (WB),Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

 Application Notes for anti-KCNJ11 antibody    WB (1/500 - 1/1000), IHC (1/100 - 1/200), IF (1/100 - 1/500), ICC (1/100 - 1/500)
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 Western Blot (WB) of anti-KCNJ11 antibody    Western blot analysis of Kir6.2 expression in HeLa (A), NIH3T3 (B) whole cell lysates.
anti-KCNJ11 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-KCNJ11 antibody    Immunohistochemical analysis of Kir6.2 staining in human brain cortex formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-KCNJ11 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-KCNJ11 antibody    Immunofluorescent analysis of Kir6.2 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 degree C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
anti-KCNJ11 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for KCNJ11. It may not necessarily be applicable to this product.
 NCBI GI #    261399884
 NCBI GeneID    3767
 NCBI Accession #    NP_001159762.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001166290.1 [Other Products]
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 UniProt Primary Accession #    Q14654 [Other Products]
 UniProt Secondary Accession #    Q2M1H7; Q58EX3; Q8IW96; B4DWI4; E9PNK0 [Other Products]
 UniProt Related Accession #    Q14654 [Other Products]
 Molecular Weight    33,263 Da
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 NCBI Official Full Name    ATP-sensitive inward rectifier potassium channel 11 isoform 2
 NCBI Official Synonym Full Names    potassium channel, inwardly rectifying subfamily J, member 11
 NCBI Official Symbol    KCNJ11 [Similar Products]
 NCBI Official Synonym Symbols   
BIR; HHF2; PHHI; IKATP; TNDM3; KIR6.2; MODY13
[Similar Products]
 NCBI Protein Information    ATP-sensitive inward rectifier potassium channel 11
 UniProt Protein Name    ATP-sensitive inward rectifier potassium channel 11
 UniProt Synonym Protein Names   
IKATP; Inward rectifier K(+) channel Kir6.2; Potassium channel, inwardly rectifying subfamily J member 11
 Protein Family    ATP-sensitive inward rectifier potassium channel
 UniProt Gene Name    KCNJ11 [Similar Products]
 UniProt Entry Name    KCJ11_HUMAN
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 NCBI Summary for KCNJ11    Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]
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 UniProt Comments for KCNJ11    Kir6.2: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Defects in KCNJ11 are the cause of familial hyperinsulinemic hypoglycemia type 2 (HHF2); also known as persistent hyperinsulinemic hypoglycemia of infancy (PPHI) or congenital hyperinsulinism. HHF is the most common cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulin secretion by low glucose levels. It causes nesidioblastosis, a diffuse abnormality of the pancreas in which there is extensive, often disorganized formation of new islets. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur. Defects in KCNJ11 are a cause of diabetes mellitus permanent neonatal (PNDM). PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy. Defects in KCNJ11 are the cause of transient neonatal diabetes mellitus type 3 (TNDM3). Neonatal diabetes mellitus, defined as insulin-requiring hyperglycemia within the first month of life, is a rare entity. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes. In a significant number of patients with transient neonatal diabetes mellitus, diabetes type 2 appears later in life. The onset and severity of TNDM3 is variable with childhood-onset diabetes, gestational diabetes or adult-onset diabetes described. Defects in KCNJ11 may contribute to non-insulin- dependent diabetes mellitus (NIDDM), also known as diabetes mellitus type 2. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.

Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: voltage-gated potassium channel complex; mitochondrion; endoplasmic reticulum; integral to plasma membrane; T-tubule; ATP-sensitive potassium channel complex; nuclear envelope; axolemma; cytosol; cell soma; plasma membrane; endosome; myelin sheath

Molecular Function: protein C-terminus binding; potassium ion binding; voltage-gated potassium channel activity; G-protein activated inward rectifier potassium channel activity; heat shock protein binding; ATP-activated inward rectifier potassium channel activity; ankyrin binding; ATP binding

Biological Process: response to drug; synaptic transmission; regulation of membrane potential; potassium ion import; energy reserve metabolic process; glucose metabolic process; response to testosterone stimulus; regulation of insulin secretion; response to estradiol stimulus; response to ATP; negative regulation of insulin secretion; neurological system process

Disease: Maturity-onset Diabetes Of The Young, Type 13; Hyperinsulinemic Hypoglycemia, Familial, 2; Diabetes Mellitus, Transient Neonatal, 3; Diabetes Mellitus, Permanent Neonatal; Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on KCNJ11    1. Paternally inherited heterozygous ABCC8/KCNJ11 mutations can manifest as a wide spectrum of congenital hyperinsulinism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KCNJ11 antibodyPathways associated with anti-KCNJ11 antibody
 Reference Product  PubMed Publications
 ABCC8 antibody  >266 publications with KCNJ11 and ABCC8
 KCNJ8 antibody  >12 publications with KCNJ11 and KCNJ8
 ABCC9 antibody  >12 publications with KCNJ11 and ABCC9
 FOXA2 antibody  >1 publications with KCNJ11 and FOXA2
 Products by Pathway  Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 ATP Sensitive Potassium Channels Pathway antibodies  ATP Sensitive Potassium Channels Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Insulin Secretion Pathway antibodies  Insulin Secretion Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 Inwardly Rectifying K+ Channels Pathway antibodies  Inwardly Rectifying K+ Channels Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Regulation Of Insulin Secretion Pathway antibodies  Regulation Of Insulin Secretion Pathway Diagram
Diseases associated with anti-KCNJ11 antibodyOrgans/Tissues associated with anti-KCNJ11 antibody
 Disease Name  Pubmed Publications
 Diabetes Mellitus Antibodies  >388 publications with KCNJ11 and Diabetes Mellitus
 Diabetes Mellitus, Type 2 Antibodies  >178 publications with KCNJ11 and Diabetes Mellitus, Type 2
 Hypoglycemia Antibodies  >132 publications with KCNJ11 and Hypoglycemia
 Congenital Hyperinsulinism Antibodies  >112 publications with KCNJ11 and Congenital Hyperinsulinism
 Diabetes Mellitus, Type 1 Antibodies  >75 publications with KCNJ11 and Diabetes Mellitus, Type 1
 Hyperglycemia Antibodies  >54 publications with KCNJ11 and Hyperglycemia
 Insulin Resistance Antibodies  >43 publications with KCNJ11 and Insulin Resistance
 Cardiovascular Diseases Antibodies  >33 publications with KCNJ11 and Cardiovascular Diseases
 Heart Diseases Antibodies  >23 publications with KCNJ11 and Heart Diseases
 Vascular Diseases Antibodies  >19 publications with KCNJ11 and Vascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >95 publications with KCNJ11 and Pancreas
 Muscle Antibodies  >35 publications with KCNJ11 and Muscle
 Brain Antibodies  >30 publications with KCNJ11 and Brain
 Liver Antibodies  >13 publications with KCNJ11 and Liver
 Kidney Antibodies  >10 publications with KCNJ11 and Kidney
 Nerve Antibodies  >7 publications with KCNJ11 and Nerve
 Intestine Antibodies  >5 publications with KCNJ11 and Intestine
 Ovary Antibodies  >4 publications with KCNJ11 and Ovary
 Thyroid Antibodies  >4 publications with KCNJ11 and Thyroid
 Eye Antibodies  >2 publications with KCNJ11 and Eye
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