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DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-KLb antibody :: Rabbit anti-Human Klotho Beta (KLb) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2016894 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Western Blot
Unit / Price
0.1 mg  /  $425 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Klotho Beta (KLb), Polyclonal Antibody

★Popular Item★
 Also Known As   

FITC-linked Antibody to Klotho Beta (KLb)

 Product Gene Name   

anti-KLb antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.11 (39408473..39453153). Location: 4p14
 OMIM    611135
 3D Structure    ModBase 3D Structure for Q86Z14
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen-specific Affinity Chromatography.
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Source    Antibody labeling
 Label    FITC
 Traits    Liquid
 Immunogen: Recombinant Klotho Beta (KLb)   
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months. Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.
Note: As fluorescence can photobleach when exposed to light, so the antibody must be protected from light.
 Other Notes    Small volumes of anti-KLb antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-KLb antibody    FITC Antibody
 Applications Tested/Suitable for anti-KLb antibody   

Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB), Immunofluorescence (IF), ELISA.

 Application Notes for anti-KLb antibody    Western blotting: 0.5-2ug/ml
Immunocytochemistry in formalin fixed cells: 5-20ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml
Immunohistochemistry in paraffin section: 5-20ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml
Optimal working dilutions must be determined by end user.
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 Western Blot of anti-KLb antibody    Western Blot
A. Sample: Recombinant KLb, Human
anti-KLb antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for KLb. It may not necessarily be applicable to this product.
 NCBI GI #    119613331
 NCBI GeneID    152831
 NCBI Accession #    EAW92925.1 [Other Products]
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 UniProt Primary Accession #    Q86Z14 [Other Products]
 UniProt Secondary Accession #    Q2M3K8 [Other Products]
 UniProt Related Accession #    Q86Z14 [Other Products]
 Molecular Weight    119,808 Da
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 NCBI Official Full Name    klotho beta
 NCBI Official Synonym Full Names    klotho beta
 NCBI Official Symbol    KLB [Similar Products]
 NCBI Official Synonym Symbols   
BKL
[Similar Products]
 NCBI Protein Information    beta-klotho; betaKlotho; klotho beta like; klotho beta-like protein
 UniProt Protein Name    Beta-klotho
 UniProt Synonym Protein Names   
Klotho beta-like protein
 Protein Family    Beta-klotho
 UniProt Gene Name    KLB [Similar Products]
 UniProt Synonym Gene Names    BKL; BetaKlotho [Similar Products]
 UniProt Entry Name    KLOTB_HUMAN
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 UniProt Comments for KLb    Klotho beta: Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p14

Cellular Component: plasma membrane; integral to membrane

Molecular Function: protein binding; fibroblast growth factor binding; fibroblast growth factor receptor binding; hydrolase activity, hydrolyzing O-glycosyl compounds

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; carbohydrate metabolic process; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response
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 Research Articles on KLb    1. betaKlotho suppresses tumor growth in hepatocellular carcinoma by regulating Akt/GSK-3beta/cyclin D1 signaling pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KLb antibodyPathways associated with anti-KLb antibody
 Reference Product  PubMed Publications
 FGF21 antibody  >29 publications with KLb and FGF21
 FGF19 antibody  >21 publications with KLb and FGF19
 FGFR4 antibody  >18 publications with KLb and FGFR4
 FGFR1 antibody  >14 publications with KLb and FGFR1
 FGF23 antibody  >5 publications with KLb and FGF23
 NR0B2 antibody  >1 publications with KLb and NR0B2
 CYP8B1 antibody  >1 publications with KLb and CYP8B1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
 FGFR Ligand Binding And Activation Pathway antibodies  FGFR Ligand Binding And Activation Pathway Diagram
Diseases associated with anti-KLb antibodyOrgans/Tissues associated with anti-KLb antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >6 publications with KLb and Disease Models, Animal
 Liver Diseases Antibodies  >6 publications with KLb and Liver Diseases
 Neoplasms Antibodies  >5 publications with KLb and Neoplasms
 Fatty Liver Antibodies  >5 publications with KLb and Fatty Liver
 Carcinoma, Hepatocellular Antibodies  >3 publications with KLb and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >3 publications with KLb and Liver Neoplasms
 Weight Loss Antibodies  >2 publications with KLb and Weight Loss
 Inflammation Antibodies  >2 publications with KLb and Inflammation
 Hyperglycemia Antibodies  >2 publications with KLb and Hyperglycemia
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with KLb and Drug-Related Side Effects and Adverse Reactions
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >27 publications with KLb and Liver
 Adipose Tissue Antibodies  >14 publications with KLb and Adipose Tissue
 Brain Antibodies  >5 publications with KLb and Brain
 Eye Antibodies  >1 publications with KLb and Eye
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