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anti-Kv1.3/KCNA3 antibody :: Rabbit Kv1.3/KCNA3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS859551
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Kv1.3/KCNA3, Polyclonal Antibody

★Popular Item★
 Also Known As   

Kv1.3/KCNA3 (Ab-135) Antibody

 Product Synonym Names    CIK3; HGK5; HLK3; HPCN3; HuKIII; KCNA3; Potassium channel Kv1.3; Potassium voltage-gated channel subfamily A member 3
 Product Gene Name   

anti-Kv1.3/KCNA3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176263
 3D Structure    ModBase 3D Structure for P22001
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Kv1.3/KCNA3 antibody detects endogenous levels of total Kv1.3/KCNA3 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Reactivity Note    Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)
 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human Kv1.3/KCNA3.
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-Kv1.3/KCNA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-Kv1.3/KCNA3 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-Kv1.3/KCNA3 antibody   

Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-Kv1.3/KCNA3 antibody    IHC: 1:50~1:100, IF: 1:100~1:500, ELISA: 1:20000
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 Testing Data of anti-Kv1.3/KCNA3 antibody    anti-Kv1.3/KCNA3 antibody Testing Data image
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 Testing Data #2 of anti-Kv1.3/KCNA3 antibody    Peptide - +
Immunohistochemistry analysis of paraffin-embedded human brain tissue using Kv1.3/KCNA3 antibody.
Immunofluorescence analysis of HuvEc cells, using Kv1.3/KCNA3 antibody.
anti-Kv1.3/KCNA3 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for Kv1.3/KCNA3. It may not necessarily be applicable to this product.
 NCBI GI #    88758565
 NCBI GeneID    3738
 NCBI Accession #    NP_002223.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_002232.4 [Other Products]
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 UniProt Primary Accession #    P22001 [Other Products]
 UniProt Secondary Accession #    Q5VWN2 [Other Products]
 UniProt Related Accession #    P22001 [Other Products]
 Molecular Weight    63,842 Da
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 NCBI Official Full Name    potassium voltage-gated channel subfamily A member 3
 NCBI Official Synonym Full Names    potassium voltage-gated channel, shaker-related subfamily, member 3
 NCBI Official Symbol    KCNA3 [Similar Products]
 NCBI Official Synonym Symbols   
MK3; HGK5; HLK3; PCN3; HPCN3; KV1.3; HUKIII
[Similar Products]
 NCBI Protein Information    potassium voltage-gated channel subfamily A member 3; potassium channel 3; type n potassium channel; voltage-gated K(+) channel HuKIII; voltage-gated potassium channel protein Kv1.3; voltage-gated potassium channel subunit Kv1.3
 UniProt Protein Name    Potassium voltage-gated channel subfamily A member 3
 UniProt Synonym Protein Names   
HGK5; HLK3; HPCN3; Voltage-gated K(+) channel HuKIII; Voltage-gated potassium channel subunit Kv1.3
 UniProt Gene Name    KCNA3 [Similar Products]
 UniProt Synonym Gene Names    HGK5 [Similar Products]
 UniProt Entry Name    KCNA3_HUMAN
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 NCBI Summary for Kv1.3/KCNA3    Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Kv1.3/KCNA3    Kv1.3: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membrane; lipid raft

Molecular Function: outward rectifier potassium channel activity; delayed rectifier potassium channel activity; voltage-gated ion channel activity

Biological Process: synaptic transmission; protein homooligomerization; potassium ion transport
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Product References and Citations for anti-Kv1.3/KCNA3 antibody

   Rubİn Vicente, J. Biol. Chem., Dec 2006; 281: 37675 - 37685.
Christine Beeton, PNAS, Nov 2006; 103: 17414 - 17419.
Christopher B. Fordyce, J. Neurosci., Aug 2005; 25: 7139 - 7149.
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 Research Articles on Kv1.3/KCNA3    1. We show the structure of the T1 domain derived from the voltage-dependent potassium channel K(v)1.3 of Homo sapiens sapiens at 1.2 A resolution crystallized under near-physiological conditions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Kv1.3/KCNA3 antibodyPathways associated with anti-Kv1.3/KCNA3 antibody
 Reference Product  PubMed Publications
 KCNA2 antibody  >20 publications with Kv1.3/KCNA3 and KCNA2
 KCNA1 antibody  >18 publications with Kv1.3/KCNA3 and KCNA1
 KCNA4 antibody  >12 publications with Kv1.3/KCNA3 and KCNA4
 KCNAB2 antibody  >2 publications with Kv1.3/KCNA3 and KCNAB2
 KCNH7 antibody  >1 publications with Kv1.3/KCNA3 and KCNH7
 KCNH2 antibody  >1 publications with Kv1.3/KCNA3 and KCNH2
 Products by Pathway  Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram
Diseases associated with anti-Kv1.3/KCNA3 antibodyOrgans/Tissues associated with anti-Kv1.3/KCNA3 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >16 publications with Kv1.3/KCNA3 and Nervous System Diseases
 Disease Models, Animal Antibodies  >8 publications with Kv1.3/KCNA3 and Disease Models, Animal
 Necrosis Antibodies  >8 publications with Kv1.3/KCNA3 and Necrosis
 Inflammation Antibodies  >7 publications with Kv1.3/KCNA3 and Inflammation
 Memory Disorders Antibodies  >5 publications with Kv1.3/KCNA3 and Memory Disorders
 Cardiovascular Diseases Antibodies  >4 publications with Kv1.3/KCNA3 and Cardiovascular Diseases
 Hyperplasia Antibodies  >3 publications with Kv1.3/KCNA3 and Hyperplasia
 Heart Diseases Antibodies  >2 publications with Kv1.3/KCNA3 and Heart Diseases
 Coma Antibodies  >2 publications with Kv1.3/KCNA3 and Coma
 Weight Loss Antibodies  >1 publications with Kv1.3/KCNA3 and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >73 publications with Kv1.3/KCNA3 and Blood
 Brain Antibodies  >42 publications with Kv1.3/KCNA3 and Brain
 Lung Antibodies  >3 publications with Kv1.3/KCNA3 and Lung
 Testis Antibodies  >2 publications with Kv1.3/KCNA3 and Testis
 Intestine Antibodies  >2 publications with Kv1.3/KCNA3 and Intestine
 Lymph Node Antibodies  >1 publications with Kv1.3/KCNA3 and Lymph Node
 Connective Tissue Antibodies  >1 publications with Kv1.3/KCNA3 and Connective Tissue
 Pancreas Antibodies  >1 publications with Kv1.3/KCNA3 and Pancreas
 Thymus Antibodies  >1 publications with Kv1.3/KCNA3 and Thymus
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