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anti-Kv4.2/KCND2 antibody :: Rabbit Kv4.2/KCND2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS859585
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Kv4.2/KCND2, Polyclonal Antibody

★Popular Item★
 Also Known As   

Kv4.2/KCND2 (Phospho-Ser616) Antibody

 Product Synonym Names    KCND2; KIAA1044; Potassium channel Kv4.2; Potassium voltage-gated channel subfamily D member 2
 Product Gene Name   

anti-Kv4.2/KCND2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605410
 3D Structure    ModBase 3D Structure for Q9NZV8
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Kv4.2/KCND2 (Phospho-Ser616) antibody detects endogenous levels of Kv4.2/KCND2 only when phosphorylated at serine 616.
 Purity/Purification    affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1mg/ml (lot specific)
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human Kv4.2/KCND2 around the phosphorylation site of serine 616 (P-E-SP-P-E).
 All Sites    Human: Ser616; Mouse: Ser616; Rat: Ser616
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-Kv4.2/KCND2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for Kv4.2/KCND2 purchase    Maintenance of PM potassium gradient is fundamental for cell survival. Both inward and outward ion rectifying voltage gated potassium channels are known but distinguishing different subtypes specifically is the job of MyBiosource's Kv4 2 KCND phospho S616 (subfamily member 2) polyclonal antibody product. Generated by rabbit immunizations and affinity isolated , this anti KCND2 antibody will quickly become a favorite. With a broad species reactivity profile, human mouse rat, this product performs equally well in Western blot or IHC research with used with any anti rabbit IgG ALEXA fluorâ® or AMP secondary antibodies . When paired with a nonPhospho Kv4 2 antibody, signaling networks, important in cell biology, may be deduced. Similar experiments with related gene products - potassium voltage gated channel protein - are possible with other ion channel isolated antibody pairs. Advice on such custom uses for related subfamily potassium channel antibody visit our Technical service website.
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 Product Categories/Family for anti-Kv4.2/KCND2 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-Kv4.2/KCND2 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-Kv4.2/KCND2 antibody    IHC: 1:50~1:100, ELISA: 1:5000
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 Testing Data of anti-Kv4.2/KCND2 antibody    P-peptide - +
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Kv4.2/KCND2 (Phospho-Ser616) antibody.
anti-Kv4.2/KCND2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for Kv4.2/KCND2. It may not necessarily be applicable to this product.
 NCBI GI #    9789987
 NCBI GeneID    3751
 NCBI Accession #    NP_036413.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012281.2 [Other Products]
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 UniProt Primary Accession #    Q9NZV8 [Other Products]
 UniProt Secondary Accession #    O95012; O95021; Q2TBD3; Q9UBY7; Q9UN98; Q9UNH9 [Other Products]
 UniProt Related Accession #    Q9NZV8 [Other Products]
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 NCBI Official Full Name    potassium voltage-gated channel subfamily D member 2
 NCBI Official Synonym Full Names    potassium voltage-gated channel, Shal-related subfamily, member 2
 NCBI Official Symbol    KCND2 [Similar Products]
 NCBI Official Synonym Symbols   
RK5; KV4.2
[Similar Products]
 NCBI Protein Information    potassium voltage-gated channel subfamily D member 2; voltage-sensitive potassium channel; voltage-gated potassium channel subunit Kv4.2
 UniProt Protein Name    Potassium voltage-gated channel subfamily D member 2
 UniProt Synonym Protein Names   
Voltage-gated potassium channel subunit Kv4.2
 UniProt Gene Name    KCND2 [Similar Products]
 UniProt Synonym Gene Names    KIAA1044 [Similar Products]
 UniProt Entry Name    KCND2_HUMAN
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 NCBI Summary for Kv4.2/KCND2    Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008]
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 UniProt Comments for Kv4.2/KCND2    Kv4.2: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; integral to plasma membrane; plasma membrane; integral to membrane; dendritic spine; intrinsic to plasma membrane

Molecular Function: protein binding; voltage-gated potassium channel activity; delayed rectifier potassium channel activity; metal ion binding; A-type (transient outward) potassium channel activity

Biological Process: regulation of action potential; synaptic transmission; protein homooligomerization
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Product References and Citations for anti-Kv4.2/KCND2 antibody

   Kong W., Am. J. Physiol. 275:H1963-H1970(1998).
Kikuno R., DNA Res. 6:197-205(1999).
Zhu X.-R., Recept. Channels 6:387-400(1999).
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 Research Articles on Kv4.2/KCND2    1. Subunit counting by single-molecule imaging revealed that the bound number of KChIP4 in each Kv4.2.KChIP4 complex was dependent on the expression level of KChIP4.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Kv4.2/KCND2 antibodyPathways associated with anti-Kv4.2/KCND2 antibody
 Reference Product  PubMed Publications
 KCNIP2 antibody  >15 publications with Kv4.2/KCND2 and KCNIP2
 KCNIP1 antibody  >11 publications with Kv4.2/KCND2 and KCNIP1
 KCNIP4 antibody  >4 publications with Kv4.2/KCND2 and KCNIP4
 KCNH2 antibody  >2 publications with Kv4.2/KCND2 and KCNH2
 IRX5 antibody  >2 publications with Kv4.2/KCND2 and IRX5
 KCNAB2 antibody  >1 publications with Kv4.2/KCND2 and KCNAB2
 Products by Pathway  Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram
Diseases associated with anti-Kv4.2/KCND2 antibodyOrgans/Tissues associated with anti-Kv4.2/KCND2 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >22 publications with Kv4.2/KCND2 and Cardiovascular Diseases
 Heart Diseases Antibodies  >21 publications with Kv4.2/KCND2 and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >12 publications with Kv4.2/KCND2 and Arrhythmias, Cardiac
 Hypertrophy Antibodies  >10 publications with Kv4.2/KCND2 and Hypertrophy
 Disease Models, Animal Antibodies  >9 publications with Kv4.2/KCND2 and Disease Models, Animal
 Nervous System Diseases Antibodies  >7 publications with Kv4.2/KCND2 and Nervous System Diseases
 Heart Failure Antibodies  >5 publications with Kv4.2/KCND2 and Heart Failure
 Cardiomegaly Antibodies  >5 publications with Kv4.2/KCND2 and Cardiomegaly
 Hypertension Antibodies  >5 publications with Kv4.2/KCND2 and Hypertension
 Seizures Antibodies  >4 publications with Kv4.2/KCND2 and Seizures
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >44 publications with Kv4.2/KCND2 and Brain
 Kidney Antibodies  >11 publications with Kv4.2/KCND2 and Kidney
 Embryonic Tissue Antibodies  >7 publications with Kv4.2/KCND2 and Embryonic Tissue
 Ovary Antibodies  >4 publications with Kv4.2/KCND2 and Ovary
 Vascular Antibodies  >3 publications with Kv4.2/KCND2 and Vascular
 Connective Tissue Antibodies  >1 publications with Kv4.2/KCND2 and Connective Tissue
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