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anti-L-Plastin antibody :: Rabbit L-Plastin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS462234
Testing Data
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

L-Plastin, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti L-Plastin/LCP1 Polyclonal antibody

 Product Synonym Names    Rabbit anti-L-Plastin; Lymphocyte cytosolic protein-1 (LCP1); L-plastin; LC64P; CP64; Plastin 2 (PLS2)
 Product Gene Name   

anti-L-Plastin antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Rat, Mouse
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 Specificity    This antibody recognizes ~70 kDa of L-plastin protein. It also reacts with human, mouse and rat. The other species are not tested.
 Purity/Purification    The Rabbit IgG is purified by Epitope Affinity Purification.
 Form/Format    This affinity purified antibody is supplied in sterile phosphatebuffered saline (pH7.2) containing antibody stabilizer
 Concentration    Size: 100 ug/200 ul (lot specific)
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 Antigen Preparation    A synthetic peptide corresponding to the C-terminus of human L-plastin protein. This sequence is identical to rat, mouse and human origins
 Positive Control    HL60 cells
 Cellular Location    Cytoplasmic
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 Preparation and Storage    The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
 Other Notes    Small volumes of anti-L-Plastin antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-L-Plastin antibody

   L-plastin is a protein normally found in leukocytes (white blood cells) only. In these cells L-plastin regulates cell movement by interacting with actins, a major cellular protein that directly controls cell movement. Normal breast epithelial cells do not have L-plastin. It only presents in breast carcinoma cells. Furthermore, the amount of L-plastin contained in the cells correlates with the degree of invasiveness of these cells. Therefore, it appears that L-plastin may be important for the motility of breast cancer cells.
 Applications Tested/Suitable for anti-L-Plastin antibody   

ELISA, Western Blot

 Application Notes for anti-L-Plastin antibody    Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
Immunohistochemistry: 0.5-2 ug/ml
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 Testing Data of anti-L-Plastin antibody    anti-L-Plastin antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for L-Plastin. It may not necessarily be applicable to this product.
 NCBI GI #    187222
 Molecular Weight    ~70 kDa
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 NCBI Official Full Name    L-plastin
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 UniProt Comments for L-Plastin    L-plastin: Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. Monomer. Interacts with AIF1. Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T- lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 13q14.3

Cellular Component: ruffle; extracellular space; focal adhesion; cytoplasm; actin filament bundle; plasma membrane; stress fiber; actin filament; cytosol; actin cytoskeleton; phagocytic cup; filopodium

Molecular Function: actin filament binding; identical protein binding; calcium ion binding; actin binding

Biological Process: actin filament bundle formation; organ regeneration; cell migration; regulation of intracellular protein transport; T cell activation during immune response
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Product References and Citations for anti-L-Plastin antibody

   Foran,E., et al, The leukocyte protein L-plastin induces proliferation, invasion and loss of E-cadherin expression in colon cancer cells. Int. J. Cancer 118 (8), 2098-2104 (2006)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-L-Plastin antibodyPathways associated with anti-L-Plastin antibody
 Reference Product  PubMed Publications
 FLNA antibody  >12 publications with L-Plastin and FLNA
 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
Organs/Tissues associated with anti-L-Plastin antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >13 publications with L-Plastin and Bone
 Connective Tissue Antibodies  >4 publications with L-Plastin and Connective Tissue
 Heart Antibodies  >3 publications with L-Plastin and Heart
 Muscle Antibodies  >3 publications with L-Plastin and Muscle
 Brain Antibodies  >3 publications with L-Plastin and Brain
 Vascular Antibodies  >2 publications with L-Plastin and Vascular
 Embryonic Tissue Antibodies  >2 publications with L-Plastin and Embryonic Tissue
 Ear Antibodies  >1 publications with L-Plastin and Ear
 Kidney Antibodies  >1 publications with L-Plastin and Kidney
 Umbilical Cord Antibodies  >1 publications with L-Plastin and Umbilical Cord
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