NP_000646.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
L-selectin
NCBI Official Synonym Full Names
selectin L
NCBI Official Synonym Symbols
TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1 [Similar Products]
NCBI Protein Information
L-selectin
UniProt Protein Name
L-selectin
UniProt Synonym Protein Names
CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; TQ1; gp90-MEL; CD_antigen: CD62L
UniProt Synonym Gene Names
UniProt Entry Name
LYAM1_HUMAN
NCBI Summary for SELL
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
UniProt Comments for SELL
SELL: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Belongs to the selectin/LECAM family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q23-q25
Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane
Molecular Function: heparin binding; protein binding; protease binding; cell adhesion molecule binding; carbohydrate binding; glycosphingolipid binding
Biological Process: regulation of immune response; blood coagulation; cell adhesion; leukocyte migration; response to ATP
Disease: Iga Nephropathy, Susceptibility To, 1
Research Articles on SELL
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Products associated with anti-SELL antibody
Pathways associated with anti-SELL antibody
Diseases associated with anti-SELL antibody
Organs/Tissues associated with anti-SELL antibody
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