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| Product Name
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LAG3, Polyclonal Antibody
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| Also Known As
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LAG3
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| OMIM
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153337
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| 3D Structure
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ModBase 3D Structure for P18627
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| Clonality
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Polyclonal
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| Host
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Rabbit
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| Species Reactivity
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Human
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| Species
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Human
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| Route
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Synthetic Peptide
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| Other Notes
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Small volumes of anti-LAG3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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| Product Categories/Family for anti-LAG3 antibody
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Polyclonal
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| Applications Tested/Suitable for anti-LAG3 antibody
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Western Blot (WB)
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| Western Blot (WB) of anti-LAG3 antibody
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Western blot analysis of extracts of various cell lines, using LAG3 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 30s.
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TOP
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| NCBI/Uniprot data below describe general gene information for LAG3. It may not necessarily be applicable to this product. |
| NCBI GI #
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251757512
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| NCBI GeneID
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3902
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| NCBI Accession #
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P18627.5
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[Other Products]
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| UniProt Primary Accession #
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P18627
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[Other Products]
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| UniProt Secondary Accession #
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Q7Z643; A8K7T9
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[Other Products]
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| UniProt Related Accession #
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P18627
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[Other Products]
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| Molecular Weight
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525
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TOP
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| NCBI Official Full Name
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Lymphocyte activation gene 3 protein
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| NCBI Official Synonym Full Names
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lymphocyte-activation gene 3
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| NCBI Official Symbol
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LAG3
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[Similar Products]
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| NCBI Official Synonym Symbols
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CD223
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[Similar Products]
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| NCBI Protein Information
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lymphocyte activation gene 3 protein
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| UniProt Protein Name
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Lymphocyte activation gene 3 protein
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| UniProt Synonym Protein Names
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Protein FDC; CD_antigen: CD223
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| Protein Family
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Lymphocyte activation gene 3 protein
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| UniProt Gene Name
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LAG3
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[Similar Products]
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| UniProt Synonym Gene Names
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FDC; LAG-3
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[Similar Products]
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| UniProt Entry Name
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LAG3_HUMAN
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| NCBI Summary for LAG3
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Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
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| UniProt Comments for LAG3
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LAG3: Involved in lymphocyte activation. Binds to HLA class-II antigens.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13.32
Cellular Component: integral to membrane; external side of plasma membrane
Molecular Function: transmembrane receptor activity; antigen binding; MHC class II protein binding
Biological Process: cell surface receptor linked signal transduction; negative regulation of interleukin-2 biosynthetic process; positive regulation of natural killer cell mediated cytotoxicity; negative regulation of T cell activation
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TOP
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| Research Articles on LAG3
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1. LAG-3 trafficking from lysosomal compartments to the cell surface is dependent on the cytoplasmic domain through protein kinase C signaling in activated T cells.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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TOP
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| Products associated with anti-LAG3 antibody | Diseases associated with anti-LAG3 antibody |
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| Organs/Tissues associated with anti-LAG3 antibody |
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TOP
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Antibody 
