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anti-LAMA1 antibody :: Rabbit anti-Human LAMA1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2524242
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LAMA1, Polyclonal Antibody

★Popular Item★
 Also Known As   

LAMA1 Polyclonal Antibody

 Product Synonym Names    LAMA, S-LAM-alpha
 Product Gene Name   

anti-LAMA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    150320
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen affinity purification
 Concentration    1mg/mL (lot specific)
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 Preparation and Storage    Store at -20 degree C. Avoid freeze/thaw cycles
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-LAMA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LAMA1 antibody

   Background: Laminin subunit alpha-1 is a protein that in humans is encoded by the LAMA1 gene. Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3 (laminin-121 or S-laminin). Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
 Applications Tested/Suitable for anti-LAMA1 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-LAMA1 antibody    IHC: 1:25-1:100
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 Immunohistochemistry (IHC) of anti-LAMA1 antibody    Immunohistochemistry of paraffin-embedded Human colon cancer tissue using LAMA1 Polyclonal Antibody at dilution of 1:25
anti-LAMA1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-LAMA1 antibody    Immunohistochemistry of paraffin-embedded Human lung cancer using LAMA1 Polyclonal Antibody at dilution of 1:25
anti-LAMA1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for LAMA1. It may not necessarily be applicable to this product.
 NCBI GI #    38788416
 NCBI GeneID    284217
 NCBI Accession #    NP_005550.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005559.3 [Other Products]
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 UniProt Related Accession #    P25391 [Other Products]
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 NCBI Official Full Name    laminin subunit alpha-1
 NCBI Official Synonym Full Names    laminin, alpha 1
 NCBI Official Symbol    LAMA1 [Similar Products]
 NCBI Official Synonym Symbols   
LAMA; PTBHS; S-LAM-alpha
[Similar Products]
 NCBI Protein Information    laminin subunit alpha-1; S-LAM alpha; S-laminin subunit alpha; laminin A chain; laminin-3 subunit alpha
 UniProt Protein Name    Laminin subunit alpha-1
 UniProt Synonym Protein Names   
Laminin A chain; Laminin-1 subunit alpha; Laminin-3 subunit alpha; S-laminin subunit alpha; S-LAM alpha
 Protein Family    Laminin
 UniProt Gene Name    LAMA1 [Similar Products]
 UniProt Synonym Gene Names    LAMA; S-LAM alpha [Similar Products]
 UniProt Entry Name    LAMA1_HUMAN
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 NCBI Summary for LAMA1    This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014]
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 UniProt Comments for LAMA1    LAMA1: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Protein type: Extracellular matrix; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 18p11.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; laminin-1 complex; laminin-3 complex; extracellular region; basement membrane; intercellular junction

Molecular Function: protein binding; extracellular matrix structural constituent; glycosphingolipid binding; receptor binding

Biological Process: regulation of cell adhesion; axon guidance; extracellular matrix organization and biogenesis; cell surface receptor linked signal transduction; regulation of embryonic development; morphogenesis of an epithelial sheet; establishment of epithelial cell polarity; cell adhesion; regulation of cell migration

Disease: Poretti-boltshauser Syndrome
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 Research Articles on LAMA1    1. Identification of biallelic mutations in LAMA1 as the cause of cerebellar dysplasia with cysts in seven affected individuals.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LAMA1 antibodyPathways associated with anti-LAMA1 antibody
 Reference Product  PubMed Publications
 LAMC1 antibody  >6 publications with LAMA1 and LAMC1
 LAMB1 antibody  >6 publications with LAMA1 and LAMB1
 LAMA5 antibody  >3 publications with LAMA1 and LAMA5
 ITGA3 antibody  >2 publications with LAMA1 and ITGA3
 ITGA6 antibody  >2 publications with LAMA1 and ITGA6
 ITGA2 antibody  >1 publications with LAMA1 and ITGA2
 ITGA1 antibody  >1 publications with LAMA1 and ITGA1
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with anti-LAMA1 antibodyOrgans/Tissues associated with anti-LAMA1 antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >2 publications with LAMA1 and Brain Diseases
 Fibrosis Antibodies  >2 publications with LAMA1 and Fibrosis
 Colorectal Neoplasms Antibodies  >2 publications with LAMA1 and Colorectal Neoplasms
 Colonic Neoplasms Antibodies  >1 publications with LAMA1 and Colonic Neoplasms
 Fatty Liver Antibodies  >1 publications with LAMA1 and Fatty Liver
 Kidney Diseases Antibodies  >1 publications with LAMA1 and Kidney Diseases
 Inflammation Antibodies  >1 publications with LAMA1 and Inflammation
 Necrosis Antibodies  >1 publications with LAMA1 and Necrosis
 Intellectual Disability Antibodies  >1 publications with LAMA1 and Intellectual Disability
 Non-alcoholic Fatty Liver Disease Antibodies  >1 publications with LAMA1 and Non-alcoholic Fatty Liver Disease
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >10 publications with LAMA1 and Embryonic Tissue
 Blood Antibodies  >9 publications with LAMA1 and Blood
 Brain Antibodies  >7 publications with LAMA1 and Brain
 Eye Antibodies  >7 publications with LAMA1 and Eye
 Muscle Antibodies  >4 publications with LAMA1 and Muscle
 Skin Antibodies  >3 publications with LAMA1 and Skin
 Uterus Antibodies  >3 publications with LAMA1 and Uterus
 Bone Antibodies  >3 publications with LAMA1 and Bone
 Placenta Antibodies  >3 publications with LAMA1 and Placenta
 Intestine Antibodies  >2 publications with LAMA1 and Intestine
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