NP_001116078.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
lysosome-associated membrane glycoprotein 2 isoform C
NCBI Official Synonym Full Names
lysosomal-associated membrane protein 2
NCBI Protein Information
lysosome-associated membrane glycoprotein 2; CD107 antigen-like family member B
UniProt Protein Name
Lysosome-associated membrane glycoprotein 2
UniProt Synonym Protein Names
CD107 antigen-like family member B
UniProt Synonym Gene Names
UniProt Entry Name
LAMP2_HUMAN
NCBI Summary for LAMP2
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
UniProt Comments for LAMP2
Function: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. Ref.3
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane. Ref.18
Tissue specificity: Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver.
Post-translational modification: O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans. Ref.14 Ref.15
Involvement in disease: Danon disease (DAND) [MIM:300257]: DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.21 Ref.22
Sequence similarities: Belongs to the LAMP family.
Research Articles on LAMP2
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Products associated with anti-LAMP2 antibody
Pathways associated with anti-LAMP2 antibody
Diseases associated with anti-LAMP2 antibody
Organs/Tissues associated with anti-LAMP2 antibody
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