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anti-LASS5 antibody :: Goat LASS5+6/CerS5+6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422118 anti-LASS5 antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LASS5+6/CerS5+6, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-LASS5+6/CerS5+6 Antibody

 Product Synonym Names    LASS5; LAG1 homolog, ceramide synthase 5; CerS5; FLJ25304; MGC45411; Trh4; LAG1 longevity assurance homolog 5; LASS5 antibody; LAG1 homolog; ceramide synthase 5 antibody; CerS5 antibody; FLJ25304 antibody; MGC45411 antibody; Trh4 antibody; LAG1 longevity assurance homolog 5 antibody; LASS5+6 / CerS5+6
 Product Gene Name   

anti-LASS5 antibody

[Similar Products]
 Product Synonym Gene Name    LASS5+6; CerS5+6 [Similar Products]
 Antibody/Peptide Pairs    LASS5+6 / CerS5+6 peptide (MBS425959) is used for blocking the activity of LASS5+6/CerS5+6 antibody (MBS422118)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    RGKVSKDDRS DVES
 OMIM    615335
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-RGKVSKDDRSDVES, from the internal region of the protein sequence according to NP_671723.1; NP_982288.1.
 Epitope    Internal region
 Note    This antibbody is expected to cross-react with the highly similar LASS6.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-LASS5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-LASS5 antibody   

Peptide ELISA (EIA)

 Application Notes for anti-LASS5 antibody    Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Preliminary experiments gave an approx. 60kDa band in lysates of HEK293, HeLa and HepG2 after 0.5ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 45.8kDa according to NP_671723.1. The 60kDa band was successfully blocked by incubation with the immunizing peptide.
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NCBI/Uniprot data below describe general gene information for LASS5. It may not necessarily be applicable to this product.
 NCBI GI #    22218345
 NCBI GeneID    91012
 NCBI Accession #    NP_671723.1 [Other Products]
 NCBI Related Accession #    NP_982288.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_147190.3 [Other Products]
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 UniProt Secondary Accession #    B4DV54 [Other Products]
 UniProt Related Accession #    Q8N5B7 [Other Products]
 Molecular Weight    39,259 Da
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 NCBI Official Full Name    ceramide synthase 5 isoform 1
 NCBI Official Synonym Full Names    ceramide synthase 5
 NCBI Official Symbol    CERS5 [Similar Products]
 NCBI Official Synonym Symbols   
Trh4; LASS5
[Similar Products]
 NCBI Protein Information    ceramide synthase 5
 UniProt Protein Name    Ceramide synthase 5
 UniProt Synonym Protein Names   
LAG1 longevity assurance homolog 5
 UniProt Gene Name    CERS5 [Similar Products]
 UniProt Synonym Gene Names    LASS5; CerS5 [Similar Products]
 UniProt Entry Name    CERS5_HUMAN
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 NCBI Summary for LASS5    This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular signaling pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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 UniProt Comments for LASS5    LASS5: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl- (C16) ceramide) in a fumonisin B1-independent manner.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transferase; EC 2.3.1.24; DNA-binding

Chromosomal Location of Human Ortholog: 12q13.12

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; nuclear membrane

Molecular Function: DNA binding; sphingosine N-acyltransferase activity

Biological Process: ceramide biosynthetic process; sphingolipid biosynthetic process
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 Research Articles on LASS5    1. mRNA level of CerS5 is higher in cancerous cell lines and decreases following the induction of apoptosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-LASS5 antibodyDiseases associated with anti-LASS5 antibody
 Products by Pathway  Pathway Diagram
 Ceramide Biosynthesis Pathway antibodies  Ceramide Biosynthesis Pathway Diagram
 Ceramide Biosynthesis Pathway antibodies  Ceramide Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid De Novo Biosynthesis Pathway antibodies  Sphingolipid De Novo Biosynthesis Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with LASS5 and Inflammation
 Breast Neoplasms Antibodies  >2 publications with LASS5 and Breast Neoplasms
 Liver Diseases Antibodies  >2 publications with LASS5 and Liver Diseases
 Disease Models, Animal Antibodies  >2 publications with LASS5 and Disease Models, Animal
 Poisoning Antibodies  >1 publications with LASS5 and Poisoning
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with LASS5 and Drug-Related Side Effects and Adverse Reactions
 Weight Loss Antibodies  >1 publications with LASS5 and Weight Loss
 Fatty Liver Antibodies  >1 publications with LASS5 and Fatty Liver
 Kidney Diseases Antibodies  >1 publications with LASS5 and Kidney Diseases
 Weight Gain Antibodies  >1 publications with LASS5 and Weight Gain
Organs/Tissues associated with anti-LASS5 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with LASS5 and Liver
 Muscle Antibodies  >3 publications with LASS5 and Muscle
 Lung Antibodies  >3 publications with LASS5 and Lung
 Brain Antibodies  >3 publications with LASS5 and Brain
 Adipose Tissue Antibodies  >2 publications with LASS5 and Adipose Tissue
 Nerve Antibodies  >2 publications with LASS5 and Nerve
 Kidney Antibodies  >2 publications with LASS5 and Kidney
 Spleen Antibodies  >1 publications with LASS5 and Spleen
 Blood Antibodies  >1 publications with LASS5 and Blood
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