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anti-LDL antibody :: Rabbit LDL Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS534421 anti-LDL antibody
Unit / Price
0.25 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LDL, Polyclonal Antibody

 Also Known As   

LDL Receptor antibody (biotin)

 Product Synonym Names    Polyclonal LDL Receptor; Anti-LDL Receptor; Low Density Lipoprotein Receptor
 Product Gene Name   

anti-LDL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    143890
 3D Structure    ModBase 3D Structure for P01130
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human LDL receptor
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 Purity/Purification    Immunoaffinity chromatography
 Form/Format    PBS with penicillin/streptomycin preservative
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 Biological Significance    Low-density lipoprotein (LDL) is one of the five major groups of lipoproteins, which in order of size, largest to smallest, are chylomicrons, VLDL, IDL, LDL and HDL, that enable lipids like cholesterol and triglycerides to be transported within the water-based bloodstream. Blood tests typically report LDL-C, the amount of cholesterol contained in LDL. In clinical context, mathematically calculated estimates of LDL-C are commonly used to estimate how much low density lipoproteins are driving progression of atherosclerosis. Direct LDL measurements are also available.
 Tag/Conjugate    Biotin
 Immunogen    LDL receptor antibody (biotin) was raised in rabbit using a specific synthetic peptide (sequence not conserved in VLDL receptor and LRP) of the LDL receptor extracellular domain as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-LDL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LDL antibody

   Rabbit polyclonal LDL Receptor antibody (biotin) conjugated
 Product Categories/Family for anti-LDL antibody    Cardiac Markers; Conjugated Polyclonal Antibodies
 Applications Tested/Suitable for anti-LDL antibody   

Flow Cytometry (FC/FACS)

 Application Notes for anti-LDL antibody    FC: 1:10
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NCBI/Uniprot data below describe general gene information for LDL. It may not necessarily be applicable to this product.
 NCBI GI #    307775412
 NCBI GeneID    3949
 NCBI Accession #    NP_001182727.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001195798.1 [Other Products]
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 UniProt Primary Accession #    P01130 [Other Products]
 UniProt Secondary Accession #    Q53ZD9; Q59FQ1; Q9UDH7; B4DII3; B4DJZ8; B4DR00; B4DTQ3; C0JYY8; H0YLU8; H0YNT7 [Other Products]
 UniProt Related Accession #    P01130 [Other Products]
 Molecular Weight    82,255 Da
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 NCBI Official Full Name    low-density lipoprotein receptor isoform 2
 NCBI Official Synonym Full Names    low density lipoprotein receptor
 NCBI Official Symbol    LDLR [Similar Products]
 NCBI Official Synonym Symbols   
FH; FHC; LDLCQ2
[Similar Products]
 NCBI Protein Information    low-density lipoprotein receptor
 UniProt Protein Name    Low-density lipoprotein receptor
 Protein Family    LDLR chaperone
 UniProt Gene Name    LDLR [Similar Products]
 UniProt Synonym Gene Names    LDL receptor [Similar Products]
 UniProt Entry Name    LDLR_HUMAN
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 NCBI Summary for LDL    The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
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 UniProt Comments for LDL    LDLR: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR are the cause of familial hypercholesterolemia (FH); a common autosomal semi- dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis). Belongs to the LDLR family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: Golgi apparatus; cell surface; membrane; integral to plasma membrane; lysosome; early endosome; late endosome; plasma membrane; endosome membrane; coated pit; receptor complex; external side of plasma membrane

Molecular Function: very-low-density lipoprotein receptor activity; low-density lipoprotein receptor activity; protein binding; low-density lipoprotein binding; calcium ion binding; clathrin heavy chain binding; glycoprotein binding

Biological Process: cholesterol metabolic process; phototransduction, visible light; lipoprotein catabolic process; receptor-mediated endocytosis; cholesterol transport; viral reproduction; cholesterol absorption; endocytosis; lipoprotein metabolic process; cholesterol homeostasis; phospholipid transport; lipid metabolic process; retinoid metabolic process

Disease: Hypercholesterolemia, Familial
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 Research Articles on LDL    1. Next generation sequencing results identify seven deleterious variants in LDLR, APOB and PCK9 genes highly associated with familial hypercholesterolemia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LDL antibodyPathways associated with anti-LDL antibody
 Reference Product  PubMed Publications
 APOE antibody  >566 publications with LDL and APOE
 APOB antibody  >449 publications with LDL and APOB
 PCSK9 antibody  >359 publications with LDL and PCSK9
 LPL antibody  >72 publications with LDL and LPL
 SREBF1 antibody  >64 publications with LDL and SREBF1
 SREBF2 antibody  >55 publications with LDL and SREBF2
 LDLRAP1 antibody  >32 publications with LDL and LDLRAP1
 MYLIP antibody  >14 publications with LDL and MYLIP
 LRPAP1 antibody  >3 publications with LDL and LRPAP1
 UBC antibody  >2 publications with LDL and UBC
 Products by Pathway  Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 LDL-mediated Lipid Transport Pathway antibodies  LDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
Diseases associated with anti-LDL antibodyOrgans/Tissues associated with anti-LDL antibody
 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >1219 publications with LDL and Atherosclerosis
 Cardiovascular Diseases Antibodies  >1067 publications with LDL and Cardiovascular Diseases
 Hypercholesterolemia Antibodies  >908 publications with LDL and Hypercholesterolemia
 Dyslipidemias Antibodies  >872 publications with LDL and Dyslipidemias
 Hyperlipidemias Antibodies  >809 publications with LDL and Hyperlipidemias
 HYPERCHOLESTEROLEMIA, FAMILIAL Antibodies  >582 publications with LDL and HYPERCHOLESTEROLEMIA, FAMILIAL
 Hyperlipoproteinemia Type II Antibodies  >408 publications with LDL and Hyperlipoproteinemia Type II
 Inflammation Antibodies  >357 publications with LDL and Inflammation
 Coronary Disease Antibodies  >294 publications with LDL and Coronary Disease
 Liver Diseases Antibodies  >225 publications with LDL and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >13 publications with LDL and Pancreas
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