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anti-LDLR antibody :: Rabbit LDLR Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9202946
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LDLR, Polyclonal Antibody

★Popular Item★
 Also Known As   

LDLR Antibody (Center)

 Product Synonym Names    Low-density lipoprotein receptor; LDL receptor; LDLR
 Product Gene Name   

anti-LDLR antibody

[Similar Products]
 Antibody/Peptide Pairs    LDLR peptide (MBS9227947) is used for blocking the activity of LDLR antibody (MBS9202946)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    391-419
 OMIM    143890
 3D Structure    ModBase 3D Structure for P01130
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human, mouse (Predicted Reactivity: Xenopus, Hamster, Pig, Rabbit, Rat)
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 Specificity    This LDLR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the Central region of human LDLR.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
 Function    Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
  Cellular Location    Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein Membrane, clathrin-coated pit; Single-pass type I membrane protein. Golgi apparatus. Early endosome. Late endosome. Cell surface. Lysosome. Note=Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9 family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-LDLR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LDLR antibody

   The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place.
 Product Categories/Family for anti-LDLR antibody    Cancer; Cardiovascular; Metabolism; Signal Transduction
 Applications Tested/Suitable for anti-LDLR antibody   

Western Blot (WB), Flow Cytometry (FC/FACS)

 Application Notes for anti-LDLR antibody    WB~~1:1000
FC~~1:10~50
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 Western Blot (WB) of anti-LDLR antibody    Western blot analysis of LDLR Antibody (Center) in mouse lung tissue lysates (35ug/lane). LDLR (arrow) was detected using the purified Pab.
anti-LDLR antibody Western Blot (WB) (WB) image
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 Flow Cytometry (FC/FACS) of anti-LDLR antibody    LDLR Antibody (Center) FC analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-LDLR antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for LDLR. It may not necessarily be applicable to this product.
 NCBI GI #    4504975
 NCBI GeneID    3949
 NCBI Accession #    NP_000518.1 [Other Products]
 NCBI Related Accession #    NP_001182727.1; NP_001182728.1; NP_001182729.1; NP_001182732.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000527.4 [Other Products]
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 UniProt Primary Accession #    P01130 [Other Products]
 UniProt Secondary Accession #    Q53ZD9; Q59FQ1; Q9UDH7; B4DII3; B4DJZ8; B4DR00; B4DTQ3; C0JYY8; H0YLU8; H0YNT7 [Other Products]
 UniProt Related Accession #    P01130 [Other Products]
 Molecular Weight    95376
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 NCBI Official Full Name    low-density lipoprotein receptor isoform 1
 NCBI Official Synonym Full Names    low density lipoprotein receptor
 NCBI Official Symbol    LDLR [Similar Products]
 NCBI Official Synonym Symbols   
FH; FHC; LDLCQ2
[Similar Products]
 NCBI Protein Information    low-density lipoprotein receptor
 UniProt Protein Name    Low-density lipoprotein receptor
 Protein Family    LDLR chaperone
 UniProt Gene Name    LDLR [Similar Products]
 UniProt Synonym Gene Names    LDL receptor [Similar Products]
 UniProt Entry Name    LDLR_HUMAN
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 NCBI Summary for LDLR    The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
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 UniProt Comments for LDLR    LDLR: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR are the cause of familial hypercholesterolemia (FH); a common autosomal semi- dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis). Belongs to the LDLR family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: Golgi apparatus; cell surface; membrane; integral to plasma membrane; lysosome; early endosome; late endosome; plasma membrane; coated pit; endosome membrane; receptor complex; external side of plasma membrane

Molecular Function: low-density lipoprotein receptor activity; very-low-density lipoprotein receptor activity; protein binding; low-density lipoprotein binding; calcium ion binding; clathrin heavy chain binding; glycoprotein binding

Biological Process: cholesterol metabolic process; receptor-mediated endocytosis; lipoprotein catabolic process; phototransduction, visible light; cholesterol transport; viral reproduction; cholesterol absorption; lipoprotein metabolic process; endocytosis; cholesterol homeostasis; phospholipid transport; lipid metabolic process; retinoid metabolic process

Disease: Hypercholesterolemia, Familial
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Product References and Citations for anti-LDLR antibody

   Hobbs,H.H., et.al., Hum. Mutat. 1 (6), 445-466 (1992)
Brown,M.S. et.al., Proc. Natl. Acad. Sci. U.S.A. 76 (7), 3330-3337 (1979)
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 Research Articles on LDLR    1. Further study of PCSK9 regulatory mechanisms may identify additional control points for pharmacological inhibition of PCSK9-mediated LDLR degradation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LDLR antibodyPathways associated with anti-LDLR antibody
 Reference Product  PubMed Publications
 APOE antibody  >565 publications with LDLR and APOE
 APOB antibody  >446 publications with LDLR and APOB
 PCSK9 antibody  >356 publications with LDLR and PCSK9
 LPL antibody  >71 publications with LDLR and LPL
 SREBF1 antibody  >63 publications with LDLR and SREBF1
 SREBF2 antibody  >54 publications with LDLR and SREBF2
 LDLRAP1 antibody  >32 publications with LDLR and LDLRAP1
 MYLIP antibody  >14 publications with LDLR and MYLIP
 LRPAP1 antibody  >3 publications with LDLR and LRPAP1
 UBC antibody  >2 publications with LDLR and UBC
 Products by Pathway  Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
Diseases associated with anti-LDLR antibodyOrgans/Tissues associated with anti-LDLR antibody
 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >1215 publications with LDLR and Atherosclerosis
 Cardiovascular Diseases Antibodies  >1063 publications with LDLR and Cardiovascular Diseases
 Hypercholesterolemia Antibodies  >905 publications with LDLR and Hypercholesterolemia
 Dyslipidemias Antibodies  >869 publications with LDLR and Dyslipidemias
 Hyperlipidemias Antibodies  >807 publications with LDLR and Hyperlipidemias
 HYPERCHOLESTEROLEMIA, FAMILIAL Antibodies  >579 publications with LDLR and HYPERCHOLESTEROLEMIA, FAMILIAL
 Hyperlipoproteinemia Type II Antibodies  >408 publications with LDLR and Hyperlipoproteinemia Type II
 Inflammation Antibodies  >355 publications with LDLR and Inflammation
 Coronary Disease Antibodies  >294 publications with LDLR and Coronary Disease
 Liver Diseases Antibodies  >222 publications with LDLR and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >13 publications with LDLR and Pancreas
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