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anti-LEFTY2 antibody :: Rabbit anti-Human LEFTY2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7045702
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LEFTY2, Polyclonal Antibody

★Popular Item★
 Also Known As   

LEFTY2 Antibody

 Product Synonym Names    Left-right determination factor 2; Endometrial bleeding-associated factor; Left-right determination factor A; Protein lefty-2; Protein lefty-A; Transforming growth factor beta-4; TGF-beta-4; LEFTY2; EBAF; LEFTA; LEFTYA; TGFB4; PSEC0024
 Product Gene Name   

anti-LEFTY2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601877
 3D Structure    ModBase 3D Structure for O00292
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Left-right determination factor 2 protein (C-310AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-7408 / sc-133732 / sc-48836
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-LEFTY2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LEFTY2 antibody

   Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
 Applications Tested/Suitable for anti-LEFTY2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-LEFTY2 antibody    Western blot
All lanes: LEFTY2 antibody at 2ug/ml+A431 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 41,38 kDa
Observed band size: 41 kDa

anti-LEFTY2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-LEFTY2 antibody    Immunohistochemistry of paraffin-embedded human endometrial cancer using MBS7045702 at dilution 1:100
anti-LEFTY2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-LEFTY2 antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS7045702 at dilution 1:100
anti-LEFTY2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for LEFTY2. It may not necessarily be applicable to this product.
 NCBI GI #    289063399
 NCBI GeneID    7044
 NCBI Accession #    NP_001165896.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001172425.2 [Other Products]
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 UniProt Primary Accession #    O00292 [Other Products]
 UniProt Secondary Accession #    O75611; Q5TE89; Q8NBQ9; B3KNH4; B4E332; E9PDM4 [Other Products]
 UniProt Related Accession #    O00292 [Other Products]
 Molecular Weight    37,093 Da
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 NCBI Official Full Name    left-right determination factor 2 isoform 2
 NCBI Official Synonym Full Names    left-right determination factor 2
 NCBI Official Symbol    LEFTY2 [Similar Products]
 NCBI Official Synonym Symbols   
EBAF; LEFTA; TGFB4; LEFTYA
[Similar Products]
 NCBI Protein Information    left-right determination factor 2
 UniProt Protein Name    Left-right determination factor 2
 UniProt Synonym Protein Names   
Endometrial bleeding-associated factor; Left-right determination factor A; Protein lefty-2; Protein lefty-A; Transforming growth factor beta-4; TGF-beta-4
 Protein Family    Left-right determination factor
 UniProt Gene Name    LEFTY2 [Similar Products]
 UniProt Synonym Gene Names    EBAF; LEFTA; LEFTYA; TGFB4; TGF-beta-4 [Similar Products]
 UniProt Entry Name    LFTY2_HUMAN
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 NCBI Summary for LEFTY2    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. This gene is closely linked to both a related family member and a related pseudogene. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
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 UniProt Comments for LEFTY2    LEFTY2: Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding. Defects in LEFTY2 are the cause of left-right axis malformations (LRAM). The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava. Belongs to the TGF-beta family.

Protein type: Cytokine; Secreted, signal peptide; Secreted; Ligand, receptor tyrosine kinase

Chromosomal Location of Human Ortholog: 1q42.1

Cellular Component: extracellular matrix; extracellular region; extracellular space

Molecular Function: cytokine activity; transforming growth factor beta receptor binding

Biological Process: cell development; platelet degranulation; regulation of apoptosis; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway
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 Research Articles on LEFTY2    1. Lefty A may account for the tumor suppressive activity of human adult stem cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-LEFTY2 antibodyDiseases associated with anti-LEFTY2 antibody
 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Regulation Of Signaling By NODAL Pathway antibodies  Regulation Of Signaling By NODAL Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
 Signaling By NODAL Pathway antibodies  Signaling By NODAL Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >12 publications with LEFTY2 and Congenital Abnormalities
 Heart Diseases Antibodies  >8 publications with LEFTY2 and Heart Diseases
 Infertility, Female Antibodies  >4 publications with LEFTY2 and Infertility, Female
 Abnormalities, Multiple Antibodies  >3 publications with LEFTY2 and Abnormalities, Multiple
 Adenocarcinoma Antibodies  >2 publications with LEFTY2 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >1 publications with LEFTY2 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >1 publications with LEFTY2 and Lung Neoplasms
 Disease Models, Animal Antibodies  >1 publications with LEFTY2 and Disease Models, Animal
 Breast Neoplasms Antibodies  >1 publications with LEFTY2 and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >1 publications with LEFTY2 and Ovarian Neoplasms
Organs/Tissues associated with anti-LEFTY2 antibody
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >25 publications with LEFTY2 and Heart
 Embryonic Tissue Antibodies  >19 publications with LEFTY2 and Embryonic Tissue
 Uterus Antibodies  >13 publications with LEFTY2 and Uterus
 Placenta Antibodies  >8 publications with LEFTY2 and Placenta
 Brain Antibodies  >7 publications with LEFTY2 and Brain
 Eye Antibodies  >5 publications with LEFTY2 and Eye
 Kidney Antibodies  >4 publications with LEFTY2 and Kidney
 Connective Tissue Antibodies  >2 publications with LEFTY2 and Connective Tissue
 Ovary Antibodies  >2 publications with LEFTY2 and Ovary
 Intestine Antibodies  >2 publications with LEFTY2 and Intestine
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