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anti-LGR5 antibody :: Rabbit LGR5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2524997
Immunohistochemistry (IHC)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LGR5, Polyclonal Antibody

★Popular Item★
 Also Known As   

LGR5 Polyclonal Antibody

 Product Synonym Names    FEX, HG38, GPR49, GPR67, GRP49
 Product Gene Name   

anti-LGR5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2524997 Technical Datasheet    Technical Datasheet PDF
 OMIM    606667
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity purification
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 Immunogen    Recombinant protein of human LGR5
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-LGR5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LGR5 antibody

   This gene encodes Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling.
 Product Categories/Family for anti-LGR5 antibody    Stem cells; Cancer
 Applications Tested/Suitable for anti-LGR5 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-LGR5 antibody    IHC: 1:25-1:100
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 Immunohistochemistry (IHC) of anti-LGR5 antibody    Immunohistochemistry of paraffin-embedded Human brain tissue using LGR5 Polyclonal Antibody at dilution 1:25
anti-LGR5 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for LGR5. It may not necessarily be applicable to this product.
 NCBI GI #    469608416
 NCBI GeneID    8549
 NCBI Accession #    BC096324 [Other Products]
 NCBI GenBank Nucleotide #    NM_001277227.1 [Other Products]
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 UniProt Secondary Accession #    Q4VAM0; Q4VAM2; Q9UP75; D8MCT0 [Other Products]
 UniProt Related Accession #    O75473 [Other Products]
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 NCBI Official Full Name    leucine-rich repeat-containing G-protein coupled receptor 5 isoform 3
 NCBI Official Synonym Full Names    leucine-rich repeat containing G protein-coupled receptor 5
 NCBI Official Symbol    LGR5 [Similar Products]
 NCBI Official Synonym Symbols   
FEX; HG38; GPR49; GPR67; GRP49
[Similar Products]
 NCBI Protein Information    leucine-rich repeat-containing G-protein coupled receptor 5; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38; leucine-rich repeat-containing G protein-coupled receptor 5; orphan G protein-coupled receptor HG38
 UniProt Protein Name    Leucine-rich repeat-containing G-protein coupled receptor 5
 UniProt Synonym Protein Names   
G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38
 Protein Family    Leucine-rich repeat-containing G-protein coupled receptor
 UniProt Gene Name    LGR5 [Similar Products]
 UniProt Synonym Gene Names    GPR49; GPR67 [Similar Products]
 UniProt Entry Name    LGR5_HUMAN
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 NCBI Summary for LGR5    The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
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 UniProt Comments for LGR5    LGR5: a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A marker of cycling, long-lived and multipotent adult stem cell populations. Target gene of Wnt signaling. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. Intestinal Lgr5+ stem cells give rise throughout life to proliferation of cells in crypts, which migrate along the crypt-villus axis, differentiating into five main cell types. Wnt signaling plays a crucial role in the proliferation and differentiation of these crypt epithelial cells. Two isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 12q22-q23

Cellular Component: integral to plasma membrane; plasma membrane; trans-Golgi network membrane

Molecular Function: G-protein coupled receptor activity; protein binding; transmembrane receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; inner ear development
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 Research Articles on LGR5    1. Study demonstrated that elevated Lgr5 expression in gastric cancer following preoperative chemotherapy is significantly associated with tumor progression, poor response to chemotherapy and shorter survival time.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LGR5 antibodyPathways associated with anti-LGR5 antibody
 Reference Product  PubMed Publications
 OLFM4 antibody  >19 publications with LGR5 and OLFM4
 DCLK1 antibody  >17 publications with LGR5 and DCLK1
 TSPAN8 antibody  >13 publications with LGR5 and TSPAN8
 JAZF1 antibody  >13 publications with LGR5 and JAZF1
 ADAMTS9 antibody  >11 publications with LGR5 and ADAMTS9
 CAMK1D antibody  >10 publications with LGR5 and CAMK1D
 THADA antibody  >10 publications with LGR5 and THADA
 CDC123 antibody  >10 publications with LGR5 and CDC123
 MBD3 antibody  >1 publications with LGR5 and MBD3
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies  RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By WNT In Cancer Pathway antibodies  Signaling By WNT In Cancer Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 TCF Dependent Signaling In Response To WNT Pathway antibodies  TCF Dependent Signaling In Response To WNT Pathway Diagram
 XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway antibodies  XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway Diagram
 Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway antibodies  Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway Diagram
 Regulation Of FZD By Ubiquitination Pathway antibodies  Regulation Of FZD By Ubiquitination Pathway Diagram
Diseases associated with anti-LGR5 antibodyOrgans/Tissues associated with anti-LGR5 antibody
 Disease Name  Pubmed Publications
 Colonic Neoplasms Antibodies  >54 publications with LGR5 and Colonic Neoplasms
 Cell Transformation, Neoplastic Antibodies  >31 publications with LGR5 and Cell Transformation, Neoplastic
 Inflammation Antibodies  >26 publications with LGR5 and Inflammation
 Neoplasm Metastasis Antibodies  >24 publications with LGR5 and Neoplasm Metastasis
 Liver Diseases Antibodies  >19 publications with LGR5 and Liver Diseases
 Liver Neoplasms Antibodies  >18 publications with LGR5 and Liver Neoplasms
 Disease Models, Animal Antibodies  >18 publications with LGR5 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >14 publications with LGR5 and Neoplasms, Experimental
 Precancerous Conditions Antibodies  >11 publications with LGR5 and Precancerous Conditions
 Necrosis Antibodies  >9 publications with LGR5 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >217 publications with LGR5 and Intestine
 Stomach Antibodies  >48 publications with LGR5 and Stomach
 Liver Antibodies  >47 publications with LGR5 and Liver
 Skin Antibodies  >29 publications with LGR5 and Skin
 Embryonic Tissue Antibodies  >27 publications with LGR5 and Embryonic Tissue
 Bone Antibodies  >23 publications with LGR5 and Bone
 Brain Antibodies  >13 publications with LGR5 and Brain
 Lymph Node Antibodies  >11 publications with LGR5 and Lymph Node
 Ovary Antibodies  >11 publications with LGR5 and Ovary
 Ear Antibodies  >8 publications with LGR5 and Ear
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