NP_055379.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,978 Da
NCBI Official Full Name
LIM/homeobox protein Lhx3 isoform b
NCBI Official Synonym Full Names
LIM homeobox 3
NCBI Protein Information
LIM/homeobox protein Lhx3
UniProt Protein Name
LIM/homeobox protein Lhx3
UniProt Synonym Gene Names
NCBI Summary for LHX3
This gene encodes a member of a large family of proteins which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
UniProt Comments for LHX3
Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1.
Research Articles on LHX3
Precautions
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Disclaimer
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Products associated with anti-LHX3 antibody
Diseases associated with anti-LHX3 antibody
Disease Name |
Pubmed Publications |
Congenital Abnormalities Antibodies |
>14 publications with LHX3 and Congenital Abnormalities |
PITUITARY HORMONE DEFICIENCY, COMBINED, 2 Antibodies |
>11 publications with LHX3 and PITUITARY HORMONE DEFICIENCY, COMBINED, 2 |
PITUITARY HORMONE DEFICIENCY, COMBINED, 3 Antibodies |
>10 publications with LHX3 and PITUITARY HORMONE DEFICIENCY, COMBINED, 3 |
Neoplasms Antibodies |
>4 publications with LHX3 and Neoplasms |
Gonadal Disorders Antibodies |
>4 publications with LHX3 and Gonadal Disorders |
Kidney Diseases Antibodies |
>2 publications with LHX3 and Kidney Diseases |
Uremia Antibodies |
>1 publications with LHX3 and Uremia |
Recurrence Antibodies |
>1 publications with LHX3 and Recurrence |
Cell Transformation, Neoplastic Antibodies |
>1 publications with LHX3 and Cell Transformation, Neoplastic |
Breast Neoplasms Antibodies |
>1 publications with LHX3 and Breast Neoplasms |
Organs/Tissues associated with anti-LHX3 antibody
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