AAH09026.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
LIG3 protein
NCBI Official Synonym Full Names
DNA ligase 3
NCBI Official Synonym Symbols
NCBI Protein Information
DNA ligase 3
UniProt Protein Name
DNA ligase 3
UniProt Synonym Protein Names
DNA ligase III; Polydeoxyribonucleotide synthase [ATP] 3
NCBI Summary for LIG3
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for LIG3
LIG3: Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Belongs to the ATP-dependent DNA ligase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.5.1.1; Ligase
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: nucleoplasm; nucleus
Molecular Function: DNA ligase activity; protein binding
Biological Process: base-excision repair, DNA ligation; double-strand break repair; double-strand break repair via homologous recombination; lagging strand elongation; nucleotide-excision repair, DNA gap filling; transcription-coupled nucleotide-excision repair; V(D)J recombination
Research Articles on LIG3
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Products associated with anti-LIG3 antibody
Pathways associated with anti-LIG3 antibody
Diseases associated with anti-LIG3 antibody
Organs/Tissues associated with anti-LIG3 antibody
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