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anti-LILRB2 antibody :: Rabbit anti-Human LILRB2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2529359
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LILRB2, Polyclonal Antibody

★Popular Item★
 Also Known As   

LILRB2 Polyclonal Antibody

 Product Synonym Names    ILT4, LIR2, CD85D, LIR-2, MIR10, LILRA6, MIR-10
 Product Gene Name   

anti-LILRB2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2529359 MSDS    MSDS PDF
 MBS2529359 Technical Datasheet    Technical Datasheet PDF
 OMIM    604815
 3D Structure    ModBase 3D Structure for BC036827
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Affinity purification
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 Immunogen    Recombinant protein of human LILRB2
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-LILRB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LILRB2 antibody

   This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13. 4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
 Applications Tested/Suitable for anti-LILRB2 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-LILRB2 antibody    IHC: 1:25-1:100
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 Immunohistochemistry (IHC) of anti-LILRB2 antibody    Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using LILRB2 Polyclonal Antibody at dilution 1:30
anti-LILRB2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-LILRB2 antibody    Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using LILRB2 Polyclonal Antibody at dilution 1:30
anti-LILRB2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for LILRB2. It may not necessarily be applicable to this product.
 NCBI GI #    618857478
 NCBI GeneID    10288
 NCBI Accession #    NP_001265335.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001278406.2 [Other Products]
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 UniProt Primary Accession #    BC036827 [Other Products]
 UniProt Secondary Accession #    O75017; Q8NHJ7; Q8NHJ8; A8MU67; C9JF29 [Other Products]
 UniProt Related Accession #    Q8N423 [Other Products]
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 NCBI Official Full Name    leukocyte immunoglobulin-like receptor subfamily B member 2 isoform 5
 NCBI Official Synonym Full Names    leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
 NCBI Official Symbol    LILRB2 [Similar Products]
 NCBI Official Synonym Symbols   
ILT4; LIR2; CD85D; ILT-4; LIR-2; MIR10; MIR-10
[Similar Products]
 NCBI Protein Information    leukocyte immunoglobulin-like receptor subfamily B member 2; CD85 antigen-like family member D; Ig-like transcript 4; monocyte/macrophage immunoglobulin-like receptor 10
 UniProt Protein Name    Leukocyte immunoglobulin-like receptor subfamily B member 2
 UniProt Synonym Protein Names   
CD85 antigen-like family member D; Immunoglobulin-like transcript 4; ILT-4; Monocyte/macrophage immunoglobulin-like receptor 10; MIR-10; CD_antigen: CD85d
 Protein Family    Leukocyte immunoglobulin-like receptor subfamily
 UniProt Gene Name    LILRB2 [Similar Products]
 UniProt Synonym Gene Names    ILT4; LIR2; MIR10; LIR-2; Leukocyte immunoglobulin-like receptor 2; ILT-4; MIR-10 [Similar Products]
 UniProt Entry Name    LIRB2_HUMAN
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 NCBI Summary for LILRB2    This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for LILRB2    LILRB2: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: extracellular space; cell surface; membrane; integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: protein binding; MHC class I protein binding; cell adhesion molecule binding; receptor activity; protein phosphatase 1 binding; inhibitory MHC class I receptor activity

Biological Process: immune response-inhibiting cell surface receptor signaling pathway; negative regulation of calcium ion transport; regulation of immune response; positive regulation of regulatory T cell differentiation; negative regulation of immune response; positive regulation of interleukin-6 production; signal transduction; positive regulation of tolerance induction; heterotypic cell-cell adhesion; negative regulation of T cell proliferation; cell surface receptor linked signal transduction; cell-cell signaling; negative regulation of antigen processing and presentation; cellular defense response; Fc receptor mediated inhibitory signaling pathway; immune response; positive regulation of T cell proliferation; positive regulation of T cell tolerance induction
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 Research Articles on LILRB2    1. ILT4 was found to be highly expressed in primary human ductal and lobular breast cancer cells, and its expression was significantly correlated with more IL-10 expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LILRB2 antibodyPathways associated with anti-LILRB2 antibody
 Reference Product  PubMed Publications
 HLA-G antibody  >46 publications with LILRB2 and HLA-G
 LILRB1 antibody  >44 publications with LILRB2 and LILRB1
 HLA-A antibody  >7 publications with LILRB2 and HLA-A
 PTPN6 antibody  >2 publications with LILRB2 and PTPN6
 HLA-B57 antibody  >1 publications with LILRB2 and HLA-B57
 B2M antibody  >1 publications with LILRB2 and B2M
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
Organs/Tissues associated with anti-LILRB2 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >84 publications with LILRB2 and Blood
 Placenta Antibodies  >12 publications with LILRB2 and Placenta
 Vascular Antibodies  >5 publications with LILRB2 and Vascular
 Uterus Antibodies  >5 publications with LILRB2 and Uterus
 Bone Marrow Antibodies  >4 publications with LILRB2 and Bone Marrow
 Liver Antibodies  >4 publications with LILRB2 and Liver
 Brain Antibodies  >2 publications with LILRB2 and Brain
 Lymph Node Antibodies  >2 publications with LILRB2 and Lymph Node
 Thymus Antibodies  >2 publications with LILRB2 and Thymus
 Intestine Antibodies  >1 publications with LILRB2 and Intestine
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