NP_001026971.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 70 kD Predicted: 73 kDa
NCBI Official Full Name
LIM domain kinase 2 isoform 1
NCBI Official Synonym Full Names
LIM domain kinase 2
NCBI Protein Information
LIM domain kinase 2
UniProt Protein Name
LIM domain kinase 2
UniProt Synonym Gene Names
NCBI Summary for LIMK2
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for LIMK2
Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.
Research Articles on LIMK2
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Products associated with anti-LIMK2 antibody
Pathways associated with anti-LIMK2 antibody
Diseases associated with anti-LIMK2 antibody
Organs/Tissues associated with anti-LIMK2 antibody
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