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anti-SCARB2 antibody :: Rabbit LIMPII Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS611922 anti-SCARB2 antibody
Unit / Price
0.1 mL  /  $600 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LIMPII (SCARB2), Polyclonal Antibody

 Also Known As   

LIMPII (Lysosomal Integral Membrane Protein II, 85kD Lysosomal Membrane Sialoglycoprotein, 85kD Lysosomal Sialoglycoprotein Scavenger Receptor Class B Member 2, CD36 Antigen (Collagen Type I Receptor Thrombospondin Receptor)-like 2, Lysosome Membrane Prot

 Product Synonym Names    Anti -LIMPII (Lysosomal Integral Membrane Protein II, 85kD Lysosomal Membrane Sialoglycoprotein, 85kD Lysosomal Sialoglycoprotein Scavenger Receptor Class B Member 2, CD36 Antigen (Collagen Type I Receptor Thrombospondin Receptor)-like 2, Lysosome Membrane Prot
 Product Gene Name   

anti-SCARB2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.11 (77079890..77135052, complement). Location: 4q21.1
 OMIM    254900
 3D Structure    ModBase 3D Structure for Q14108
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Canine, Human, Mouse, Rat
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 Specificity    Recognzies mouse LIMPII at ~85kD. Species Crossreactivity: human, rat and canine
 Purity/Purification    Serum
Serum
 Form/Format    Supplied as a liquid, 0.05% sodium azide.
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 Immunogen    Synthetic peptide corresponding to the C-terminal of mouse LIMPII. Cellular Localization: Lysosome membrane; Multi-pass membrane protein.
 Positive Control    3T3 Whole Cell Lysate
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
 Other Notes    Small volumes of anti-SCARB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-SCARB2 antibody

   Lysosomal integral membrane protein II (LIMPII, also known as lpg85 and CD36L2) is a member of the scavenger receptor class B, member 2 family. LIMP II is ubiquitously expressed in most higher organisms and is a major lysosomal and endosomal membrane marker. The major portion of LIMPII resides on the luminal side and contains numerous N-glycosylation sites. To date, studies have suggested that this 478-residue type III glycoprotein may play a role as a scavenger receptor, in cell adhesion and fatty acid transportation similar to that of CD36.
 Product Categories/Family for anti-SCARB2 antibody    Antibodies; Abs to Protein Kinases
 Applications Tested/Suitable for anti-SCARB2 antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-SCARB2 antibody    Suitable for use in Western Blot, Immunoprecipitation, Immunoflourescence, Immunohistochemistry and Immunocytochemistry.
Dilution: Western Blot: 1:1000
Immunoprecipitation: 1:100
Immunoflourescence: 1:50-1:250
Immunohistochemistry: 1:200
Immunocytochemistry: 1:250
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NCBI/Uniprot data below describe general gene information for SCARB2. It may not necessarily be applicable to this product.
 NCBI GI #    323714253
 NCBI GeneID    950
 NCBI Accession #    NP_001191184.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001204255.1 [Other Products]
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 UniProt Primary Accession #    Q14108 [Other Products]
 UniProt Secondary Accession #    Q53Y63; B4DKD8; E7EM68 [Other Products]
 UniProt Related Accession #    Q14108 [Other Products]
 Molecular Weight    54,290 Da [Similar Products]
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 NCBI Official Full Name    lysosome membrane protein 2 isoform 2
 NCBI Official Synonym Full Names    scavenger receptor class B, member 2
 NCBI Official Symbol    SCARB2 [Similar Products]
 NCBI Official Synonym Symbols   
AMRF; EPM4; LGP85; CD36L2; HLGP85; LIMP-2; LIMPII; SR-BII
[Similar Products]
 NCBI Protein Information    lysosome membrane protein 2; LIMP II; CD36 antigen-like 2; lysosome membrane protein II; 85 kDa lysosomal membrane sialoglycoprotein; 85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II)
 UniProt Protein Name    Lysosome membrane protein 2
 UniProt Synonym Protein Names   
85 kDa lysosomal membrane sialoglycoprotein; LGP85; CD36 antigen-like 2; Lysosome membrane protein II; LIMP II; Scavenger receptor class B member 2
 Protein Family    Lysosome membrane protein
 UniProt Gene Name    SCARB2 [Similar Products]
 UniProt Synonym Gene Names    CD36L2; LIMPII; LGP85; LIMP II [Similar Products]
 UniProt Entry Name    SCRB2_HUMAN
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 NCBI Summary for SCARB2    The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
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 UniProt Comments for SCARB2    SCARB2: Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. Defects in SCARB2 are the cause of progressive myoclonic epilepsy type 4 with or without renal failure (EPM4). An autosomal recessive progressive myoclonic epilepsy associated with renal failure in some cases. Cognitive function is preserved. Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles. Cognitive function is preserved. Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease. Belongs to the CD36 family.

Protein type: Receptor, misc.; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q21.1

Cellular Component: lysosomal lumen; focal adhesion; membrane; lysosomal membrane; integral to membrane

Molecular Function: protein binding; enzyme binding; receptor activity

Biological Process: protein targeting to lysosome; cell adhesion

Disease: Epilepsy, Progressive Myoclonic 4, With Or Without Renal Failure
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 Research Articles on SCARB2    1. SCARB2 is implicated in the lysosomal pathway recently associated with Parkinson disease (PD) pathogenesis. The rs6812193 polymorphism doesn't increase susceptibility to PD in the Greek population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SCARB2 antibodyPathways associated with anti-SCARB2 antibody
 Reference Product  PubMed Publications
 IFNG antibody  >1 publications with SCARB2 and IFNG
 PPARG antibody  >1 publications with SCARB2 and PPARG
 Products by Pathway  Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
Diseases associated with anti-SCARB2 antibodyOrgans/Tissues associated with anti-SCARB2 antibody
 Disease Name  Pubmed Publications
 EPILEPSY, PROGRESSIVE MYOCLONIC 4, WITH OR WITHOUT RENAL FAILURE Antibodies  >177561 publications with SCARB2 and EPILEPSY, PROGRESSIVE MYOCLONIC 4, WITH OR WITHOUT RENAL FAILURE
 Neoplasms Antibodies  >13 publications with SCARB2 and Neoplasms
 Kidney Diseases Antibodies  >8 publications with SCARB2 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >6 publications with SCARB2 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >5 publications with SCARB2 and Adenocarcinoma
 Liver Neoplasms Antibodies  >5 publications with SCARB2 and Liver Neoplasms
 Disease Models, Animal Antibodies  >4 publications with SCARB2 and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >4 publications with SCARB2 and Carcinoma, Hepatocellular
 Arteriosclerosis Antibodies  >4 publications with SCARB2 and Arteriosclerosis
 Liver Diseases Antibodies  >4 publications with SCARB2 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Mouth Antibodies  >15 publications with SCARB2 and Mouth
 Liver Antibodies  >11 publications with SCARB2 and Liver
 Kidney Antibodies  >10 publications with SCARB2 and Kidney
 Blood Antibodies  >9 publications with SCARB2 and Blood
 Brain Antibodies  >6 publications with SCARB2 and Brain
 Muscle Antibodies  >4 publications with SCARB2 and Muscle
 Ovary Antibodies  >4 publications with SCARB2 and Ovary
 Heart Antibodies  >4 publications with SCARB2 and Heart
 Skin Antibodies  >3 publications with SCARB2 and Skin
 Spinal Cord Antibodies  >3 publications with SCARB2 and Spinal Cord
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