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anti-LMBRD1 antibody :: Rabbit anti-Human LMBRD1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7004297
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LMBRD1, Polyclonal Antibody

★Popular Item★
 Also Known As   

LMBRD1 Antibody

 Product Synonym Names    Probable lysosomal cobalamin transporter; HDAg-L-interacting protein NESI; LMBR1 domain-containing protein 1; Nuclear export signal-interacting protein; LMBRD1; C6orf209; NESI; BM-021; CD001; MSTP044
 Product Gene Name   

anti-LMBRD1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    277380
 3D Structure    ModBase 3D Structure for Q9NUN5
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%,Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Probable lysosomal cobalamin transporter protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-LMBRD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LMBRD1 antibody

   Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV).
 Applications Tested/Suitable for anti-LMBRD1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-LMBRD1 antibody    Western Blot
Positive WB detected in:Mouse liver tissue,Mouse kidney tissue
All lanes: LMBRD1 antibody at 4ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 62,45,54,22 kDa
Observed band size: 62,54 kDa

anti-LMBRD1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-LMBRD1 antibody    Immunohistochemistry of paraffin-embedded human brain tissue using MBS7004297 at dilution of 1:100
anti-LMBRD1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for LMBRD1. It may not necessarily be applicable to this product.
 NCBI GI #    261878497
 NCBI GeneID    55788
 NCBI Accession #    NP_060838.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_018368.3 [Other Products]
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 UniProt Primary Accession #    Q9NUN5 [Other Products]
 UniProt Secondary Accession #    Q5VUN6; Q86Y70; Q96FW4; Q9BY56; Q9NZD6; A8K204; E1P531 [Other Products]
 UniProt Related Accession #    Q9NUN5 [Other Products]
 Molecular Weight    21,394 Da
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 NCBI Official Full Name    probable lysosomal cobalamin transporter
 NCBI Official Synonym Full Names    LMBR1 domain containing 1
 NCBI Official Symbol    LMBRD1 [Similar Products]
 NCBI Official Synonym Symbols   
NESI; LMBD1; MAHCF; C6orf209
[Similar Products]
 NCBI Protein Information    probable lysosomal cobalamin transporter
 UniProt Protein Name    Probable lysosomal cobalamin transporter
 UniProt Synonym Protein Names   
HDAg-L-interacting protein NESI; LMBR1 domain-containing protein 1; Nuclear export signal-interacting protein
 UniProt Gene Name    LMBRD1 [Similar Products]
 UniProt Synonym Gene Names    C6orf209; NESI [Similar Products]
 UniProt Entry Name    LMBD1_HUMAN
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 NCBI Summary for LMBRD1    This gene encodes a lysosomal membrane protein that may be involved in the transport and metabolism of cobalamin. This protein also interacts with the large form of the hepatitis delta antigen and may be required for the nucleocytoplasmic shuttling of the hepatitis delta virus. Mutations in this gene are associated with the vitamin B12 metabolism disorder termed, homocystinuria-megaloblastic anemia complementation type F.[provided by RefSeq, Oct 2009]
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 UniProt Comments for LMBRD1    LMBRD1: Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV). Defects in LMBRD1 are the cause of methylmalonic aciduria and homocystinuria type cblF (MMAHCF). A disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl). It is due to accumulation of free cobalamin in lysosomes, thus hindering its conversion to cofactors. Clinical features include developmental delay, stomatitis, glossitis, seizures and methylmalonic aciduria responsive to vitamin B12. Belongs to the LIMR family. LMBRD1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q13

Cellular Component: clathrin-coated endocytic vesicle; integral to membrane; lysosomal membrane; membrane; plasma membrane

Molecular Function: cobalamin binding; insulin receptor binding

Biological Process: cobalamin metabolic process; negative regulation of glucose import; negative regulation of insulin receptor signaling pathway; negative regulation of protein kinase B signaling cascade; viral reproduction; vitamin metabolic process; water-soluble vitamin metabolic process

Disease: Methylmalonic Aciduria And Homocystinuria, Cblf Type
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 Research Articles on LMBRD1    1. Results propose a model whereby membrane-bound LMBD1 and ABCD4 facilitate the vectorial delivery of lysosomal vitamin B12 to cytoplasmic MMACHC.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LMBRD1 antibodyPathways associated with anti-LMBRD1 antibody
 Reference Product  PubMed Publications
 MTR antibody  >2 publications with LMBRD1 and MTR
 MMACHC antibody  >2 publications with LMBRD1 and MMACHC
 MTRR antibody  >1 publications with LMBRD1 and MTRR
 MMADHC antibody  >1 publications with LMBRD1 and MMADHC
 Products by Pathway  Pathway Diagram
 Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway antibodies  Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 Vitamin Digestion And Absorption Pathway antibodies  Vitamin Digestion And Absorption Pathway Diagram
 Vitamin Digestion And Absorption Pathway antibodies  Vitamin Digestion And Absorption Pathway Diagram
Diseases associated with anti-LMBRD1 antibody
 Disease Name  Pubmed Publications
 Cerebral Hemorrhage Antibodies  >1 publications with LMBRD1 and Cerebral Hemorrhage
 Nerve Degeneration Antibodies  >1 publications with LMBRD1 and Nerve Degeneration
 Neurobehavioral Manifestations Antibodies  >1 publications with LMBRD1 and Neurobehavioral Manifestations
 Methylmalonic Aciduria and Homocystinuria, CblF Type Antibodies  >1 publications with LMBRD1 and Methylmalonic Aciduria and Homocystinuria, CblF Type
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