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anti-LMNB1 antibody :: Rabbit anti-Human LMNB1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7049551
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LMNB1, Polyclonal Antibody

★Popular Item★
 Also Known As   

LMNB1 Antibody

 Product Synonym Names    Lamin-B1; LMNB1; LMN2; LMNB
 Product Gene Name   

anti-LMNB1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M34458 mRNA
 3D Structure    ModBase 3D Structure for P20700
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Lamin-B1 protein (385-552AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-30264 / sc-6217 / sc-6216 / sc-20682
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-LMNB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LMNB1 antibody

   Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
 Applications Tested/Suitable for anti-LMNB1 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-LMNB1 antibody    IHC: 1: 20-1: 200
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 Immunohistochemistry (IHC) of anti-LMNB1 antibody    Immunohistochemistry of paraffin-embedded human gastric cancer using MBS7049551 at dilution of 1:100
anti-LMNB1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-LMNB1 antibody    Immunohistochemistry of paraffin-embedded human lung cancer using MBS7049551 at dilution of 1:100
anti-LMNB1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for LMNB1. It may not necessarily be applicable to this product.
 NCBI GI #    5031877
 NCBI GeneID    4001
 NCBI Accession #    NP_005564.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005573.3 [Other Products]
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 UniProt Primary Accession #    P20700 [Other Products]
 UniProt Secondary Accession #    Q3SYN7; Q96EI6; B2R6J6 [Other Products]
 UniProt Related Accession #    P20700 [Other Products]
 Molecular Weight    66,408 Da
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 NCBI Official Full Name    lamin-B1 isoform 1
 NCBI Official Synonym Full Names    lamin B1
 NCBI Official Symbol    LMNB1 [Similar Products]
 NCBI Official Synonym Symbols   
LMN; ADLD; LMN2; LMNB
[Similar Products]
 NCBI Protein Information    lamin-B1
 UniProt Protein Name    Lamin-B1
 Protein Family    Lamin
 UniProt Gene Name    LMNB1 [Similar Products]
 UniProt Synonym Gene Names    LMN2; LMNB [Similar Products]
 UniProt Entry Name    LMNB1_HUMAN
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 NCBI Summary for LMNB1    This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
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 UniProt Comments for LMNB1    Lamin B1: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 5q23.2

Cellular Component: membrane; nuclear envelope; nuclear membrane; nucleoplasm

Molecular Function: protein binding

Disease: Leukodystrophy, Demyelinating, Adult-onset, Autosomal Dominant
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 Research Articles on LMNB1    1. Data show that lamins A and B are differently processed in staurosporine and beta-Amyloid peptide fragments Abeta42-treated cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LMNB1 antibodyPathways associated with anti-LMNB1 antibody
 Reference Product  PubMed Publications
 LMNA antibody  >18 publications with LMNB1 and LMNA
 SYNE1 antibody  >1 publications with LMNB1 and SYNE1
 CDK1 antibody  >1 publications with LMNB1 and CDK1
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Breakdown Of The Nuclear Lamina Pathway antibodies  Breakdown Of The Nuclear Lamina Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
Diseases associated with anti-LMNB1 antibodyOrgans/Tissues associated with anti-LMNB1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >29 publications with LMNB1 and Nervous System Diseases
 Pelizaeus-Merzbacher Disease Antibodies  >8 publications with LMNB1 and Pelizaeus-Merzbacher Disease
 Adenocarcinoma Antibodies  >5 publications with LMNB1 and Adenocarcinoma
 Liver Diseases Antibodies  >4 publications with LMNB1 and Liver Diseases
 Liver Neoplasms Antibodies  >3 publications with LMNB1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with LMNB1 and Carcinoma, Hepatocellular
 Disease Models, Animal Antibodies  >2 publications with LMNB1 and Disease Models, Animal
 Inflammation Antibodies  >2 publications with LMNB1 and Inflammation
 Chromosome Breakage Antibodies  >1 publications with LMNB1 and Chromosome Breakage
 Nerve Degeneration Antibodies  >1 publications with LMNB1 and Nerve Degeneration
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >22 publications with LMNB1 and Brain
 Blood Antibodies  >11 publications with LMNB1 and Blood
 Skin Antibodies  >7 publications with LMNB1 and Skin
 Bone Antibodies  >6 publications with LMNB1 and Bone
 Muscle Antibodies  >6 publications with LMNB1 and Muscle
 Liver Antibodies  >4 publications with LMNB1 and Liver
 Embryonic Tissue Antibodies  >2 publications with LMNB1 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with LMNB1 and Pancreas
 Lung Antibodies  >1 publications with LMNB1 and Lung
 Intestine Antibodies  >1 publications with LMNB1 and Intestine
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