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anti-LNX1 antibody :: Goat LNX1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421538 anti-LNX1 antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LNX1, Polyclonal Antibody

 Also Known As   

Goat anti-LNX1 Antibody

 Product Synonym Names    LNX1; ligand of numb-protein X 1; LNX; MPDZ; PDZRN2; multi-PDZ-domain-containing protein; LNX1 antibody; ligand of numb-protein X 1 antibody; LNX antibody; MPDZ antibody; PDZRN2 antibody; multi-PDZ-domain-containing protein antibody
 Product Gene Name   

anti-LNX1 antibody

[Similar Products]
 Antibody/Peptide Pairs    LNX1 peptide (MBS426434) is used for blocking the activity of LNX1 antibody (MBS421538)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    PDAYRPRDDS FH
 OMIM    609732
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-PDAYRPRDDSFH, from the internal region of the protein sequence according to NP_116011.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-LNX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-LNX1 antibody   

Peptide ELISA (EIA)

 Application Notes for anti-LNX1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Preliminary experiments gave next to 70kDa bands at approx 75kDa and 27kDa in Human Kidney and Lung lysates after 0.5 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the extra bands we observe given the calculated size of 69.7kDa according to NP_116011.1. The detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).
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NCBI/Uniprot data below describe general gene information for LNX1. It may not necessarily be applicable to this product.
 NCBI GI #    14249128
 NCBI GeneID    84708
 NCBI Accession #    NP_116011.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_032622.1 [Other Products]
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 UniProt Secondary Accession #    Q4W5K7; Q8N4C2; Q96MJ7; Q9BY20 [Other Products]
 UniProt Related Accession #    Q8TBB1 [Other Products]
 Molecular Weight    69,643 Da
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 NCBI Official Full Name    ligand of numb-protein X 1
 NCBI Official Synonym Full Names    ligand of numb-protein X 1
 NCBI Official Symbol    LNX1 [Similar Products]
 NCBI Official Synonym Symbols   
LNX; MPDZ; PDZRN2
[Similar Products]
 NCBI Protein Information    E3 ubiquitin-protein ligase LNX
 UniProt Protein Name    E3 ubiquitin-protein ligase LNX
 UniProt Synonym Protein Names   
Ligand of Numb-protein X 1; Numb-binding protein 1; PDZ domain-containing RING finger protein 2
 Protein Family    E3 ubiquitin-protein ligase
 UniProt Gene Name    LNX1 [Similar Products]
 UniProt Synonym Gene Names    LNX; PDZRN2 [Similar Products]
 UniProt Entry Name    LNX1_HUMAN
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 NCBI Summary for LNX1    This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for LNX1    LNX1: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Adaptor/scaffold; Ubiquitin ligase; Ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: cytoplasm

Molecular Function: ligase activity; PDZ domain binding; protein binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: protein homooligomerization; protein ubiquitination during ubiquitin-dependent protein catabolic process
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 Research Articles on LNX1    1. LNX was closely related to human gliomas and suggested it plays an important role in gliomas by notch signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LNX1 antibodyPathways associated with anti-LNX1 antibody
 Reference Product  PubMed Publications
 NUMB antibody  >28 publications with LNX1 and NUMB
 IGSF5 antibody  >1 publications with LNX1 and IGSF5
 CXADR antibody  >1 publications with LNX1 and CXADR
 RHOC antibody  >1 publications with LNX1 and RHOC
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
Diseases associated with anti-LNX1 antibodyOrgans/Tissues associated with anti-LNX1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with LNX1 and Nervous System Diseases
 Brain Diseases Antibodies  >2 publications with LNX1 and Brain Diseases
 Cardiovascular Diseases Antibodies  >1 publications with LNX1 and Cardiovascular Diseases
 Inflammation Antibodies  >1 publications with LNX1 and Inflammation
 Disease Models, Animal Antibodies  >1 publications with LNX1 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with LNX1 and Brain
 Kidney Antibodies  >3 publications with LNX1 and Kidney
 Pancreas Antibodies  >2 publications with LNX1 and Pancreas
 Embryonic Tissue Antibodies  >2 publications with LNX1 and Embryonic Tissue
 Heart Antibodies  >2 publications with LNX1 and Heart
 Testis Antibodies  >2 publications with LNX1 and Testis
 Lung Antibodies  >1 publications with LNX1 and Lung
 Muscle Antibodies  >1 publications with LNX1 and Muscle
 Prostate Antibodies  >1 publications with LNX1 and Prostate
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