Q86WA8.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
89,660 Da
NCBI Official Full Name
Lon protease homolog 2, peroxisomal
NCBI Official Synonym Full Names
lon peptidase 2, peroxisomal
NCBI Official Synonym Symbols
NCBI Protein Information
lon protease homolog 2, peroxisomal
UniProt Protein Name
Lon protease homolog 2, peroxisomal
UniProt Synonym Protein Names
Lon protease-like protein 2
UniProt Synonym Gene Names
UniProt Entry Name
LONP2_HUMAN
UniProt Comments for LONP2
LONP2: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. Belongs to the peptidase S16 family.
Protein type: EC 3.4.21.-; Protease
Chromosomal Location of Human Ortholog: 16q12.1
Cellular Component: membrane; nucleus; peroxisomal matrix; peroxisome
Molecular Function: ATP binding; ATP-dependent peptidase activity; enzyme binding; peptidase activity; protease binding; protein binding; receptor binding; serine-type endopeptidase activity
Biological Process: misfolded or incompletely synthesized protein catabolic process; peroxisome organization and biogenesis; protein import into peroxisome matrix; protein processing; protein targeting to peroxisome; regulation of fatty acid beta-oxidation; response to organic cyclic substance
Research Articles on LONP2
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Pathways associated with anti-LONP2 antibody
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