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anti-LPAR1 antibody :: Rabbit LPAR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2542797
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LPAR1, Polyclonal Antibody

★Popular Item★
 Also Known As   

LPAR1 Polyclonal Antibody

 Product Synonym Names    EDG2; LPA1; VZG1; GPR26; edg-2; vzg-1; Gpcr26; Mrec1.3; rec.1.3
 Product Gene Name   

anti-LPAR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    U80811 mRNA
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purification
 Concentration    1.2mg/ml (lot specific)
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 Immunogen    Synthetic peptide of human LPAR1
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-22207 / sc-22209
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 Preparation and Storage    Store at -20 degree C. Avoid freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-LPAR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LPAR1 antibody

   The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion.
 Applications Tested/Suitable for anti-LPAR1 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-LPAR1 antibody    ELISA: 1:2000-5000
IHC: 1:25-100
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 Immunohistochemistry (IHC) of anti-LPAR1 antibody    Immunohistochemistry of paraffin-embedded Human liver cancer tissue using LPAR1 Polyclonal Antibody at dilution 1:20
anti-LPAR1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-LPAR1 antibody    Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using LPAR1 Polyclonal Antibody at dilution 1:20
anti-LPAR1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for LPAR1. It may not necessarily be applicable to this product.
 NCBI GI #    16950638
 NCBI GeneID    1902
 NCBI GenBank Nucleotide #    NM_057159.2 [Other Products]
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 UniProt Secondary Accession #    O00656; O00722; P78351; B4DK36 [Other Products]
 UniProt Related Accession #    Q92633 [Other Products]
 Molecular Weight    41,346 Da
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 NCBI Official Full Name    lysophosphatidic acid receptor 1
 NCBI Official Synonym Full Names    lysophosphatidic acid receptor 1
 NCBI Official Symbol    LPAR1 [Similar Products]
 NCBI Official Synonym Symbols   
EDG2; LPA1; VZG1; GPR26; edg-2; vzg-1; Gpcr26; Mrec1.3; rec.1.3
[Similar Products]
 NCBI Protein Information    lysophosphatidic acid receptor 1
 UniProt Protein Name    Lysophosphatidic acid receptor 1
 UniProt Synonym Protein Names   
Lysophosphatidic acid receptor Edg-2
 Protein Family    Lysophosphatidic acid receptor
 UniProt Gene Name    LPAR1 [Similar Products]
 UniProt Synonym Gene Names    EDG2; LPA1; LPA receptor 1; LPA-1 [Similar Products]
 UniProt Entry Name    LPAR1_HUMAN
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 NCBI Summary for LPAR1    The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq, Jul 2008]
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 UniProt Comments for LPAR1    LPAR1: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 9q31.3

Cellular Component: cell surface; endocytic vesicle; endosome; integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding

Biological Process: elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; phospholipase C activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAPKKK cascade; positive regulation of Rho protein signal transduction; positive regulation of stress fiber formation; regulation of cell shape
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 Research Articles on LPAR1    1. These results suggest that autotaxin-LPA-LPA receptor 1-AKT1 signaling axis is critical for maintaining Cancer stem cells(CSC) characteristics through an autocrine loop and provide a novel therapeutic target for ovarian CSCs
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LPAR1 antibodyPathways associated with anti-LPAR1 antibody
 Reference Product  PubMed Publications
 LPAR4 antibody  >8 publications with LPAR1 and LPAR4
 LPAR6 antibody  >7 publications with LPAR1 and LPAR6
 LPAR5 antibody  >5 publications with LPAR1 and LPAR5
 GNAI1 antibody  >1 publications with LPAR1 and GNAI1
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 LPA Receptor Mediated Events Pathway antibodies  LPA Receptor Mediated Events Pathway Diagram
 Lysosphingolipid And LPA Receptors Pathway antibodies  Lysosphingolipid And LPA Receptors Pathway Diagram
Diseases associated with anti-LPAR1 antibodyOrgans/Tissues associated with anti-LPAR1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7 publications with LPAR1 and Nervous System Diseases
 Fibrosis Antibodies  >6 publications with LPAR1 and Fibrosis
 Disease Models, Animal Antibodies  >5 publications with LPAR1 and Disease Models, Animal
 Inflammation Antibodies  >5 publications with LPAR1 and Inflammation
 Adenocarcinoma Antibodies  >5 publications with LPAR1 and Adenocarcinoma
 Liver Diseases Antibodies  >4 publications with LPAR1 and Liver Diseases
 Hypertension Antibodies  >4 publications with LPAR1 and Hypertension
 Liver Neoplasms Antibodies  >4 publications with LPAR1 and Liver Neoplasms
 Lung Neoplasms Antibodies  >3 publications with LPAR1 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with LPAR1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >11 publications with LPAR1 and Liver
 Lung Antibodies  >8 publications with LPAR1 and Lung
 Bone Antibodies  >7 publications with LPAR1 and Bone
 Vascular Antibodies  >6 publications with LPAR1 and Vascular
 Uterus Antibodies  >6 publications with LPAR1 and Uterus
 Nerve Antibodies  >5 publications with LPAR1 and Nerve
 Heart Antibodies  >5 publications with LPAR1 and Heart
 Muscle Antibodies  >4 publications with LPAR1 and Muscle
 Skin Antibodies  >3 publications with LPAR1 and Skin
 Bone Marrow Antibodies  >3 publications with LPAR1 and Bone Marrow
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