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anti-LPXN antibody :: Rabbit anti-Human LPXN Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7000445
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LPXN, Polyclonal Antibody

★Popular Item★
 Also Known As   

LPXN Antibody

 Product Synonym Names    Leupaxin; LPXN; LDLP
 Product Gene Name   

anti-LPXN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605390
 3D Structure    ModBase 3D Structure for O60711
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%,Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Leupaxin protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-241521 / sc-241524
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-LPXN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LPXN antibody

   Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.
 Applications Tested/Suitable for anti-LPXN antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

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 Immunohistochemistry (IHC) of anti-LPXN antibody    Immunohistochemistry of paraffin-embedded human prostate cancer using MBS7000445 at dilution of 1:100
anti-LPXN antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-LPXN antibody    Immunohistochemistry of paraffin-embedded human lymph node tissue using MBS7000445 at dilution of 1:100
anti-LPXN antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-LPXN antibody    Immunofluorescent analysis of PC3 cells using MBS7000445 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-LPXN antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-LPXN antibody    Western Blot
Positive WB detected in: Jurkat whole cell lysate
All lanes: LPXN antibody at 2ug/ml
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 44 KDa
Observed band size: 44 KDa

anti-LPXN antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for LPXN. It may not necessarily be applicable to this product.
 NCBI GI #    221316659
 NCBI GeneID    9404
 NCBI Accession #    NP_001137467.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001143995.2 [Other Products]
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 UniProt Primary Accession #    O60711 [Other Products]
 UniProt Secondary Accession #    Q53FW6; Q6FI07; B2R8B4; B4DV71 [Other Products]
 UniProt Related Accession #    O60711 [Other Products]
 Molecular Weight    43,750 Da
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 NCBI Official Full Name    leupaxin isoform 1
 NCBI Official Synonym Full Names    leupaxin
 NCBI Official Symbol    LPXN [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    leupaxin
 UniProt Protein Name    Leupaxin
 Protein Family    Leupaxin
 UniProt Gene Name    LPXN [Similar Products]
 UniProt Synonym Gene Names    LDLP [Similar Products]
 UniProt Entry Name    LPXN_HUMAN
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 NCBI Summary for LPXN    The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
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 UniProt Comments for LPXN    leupaxin: a LIM domain-containing cytoplasmic protein preferentially expressed in hematopoietic cells. Homologous to the focal adhesion protein, paxillin. Associates with PYK2, a member of focal adhesion kinase family, it may participate in signaling at sites of adhesion. .

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: cell projection; cytoplasm; focal adhesion; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; podosome

Molecular Function: protein binding; transcription cofactor activity; zinc ion binding

Biological Process: cell adhesion; negative regulation of B cell receptor signaling pathway; negative regulation of cell adhesion; protein complex assembly; regulation of cell adhesion mediated by integrin; regulation of transcription, DNA-dependent; signal transduction; transcription, DNA-dependent
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 Research Articles on LPXN    1. first evidence of dynamic regulation of leupaxin localization and tyrosine phosphorylation by G-Protein Coupled Receptors
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LPXN antibodyDiseases associated with anti-LPXN antibody
 Reference Product  PubMed Publications
 SRC antibody  >3 publications with LPXN and SRC
 PTK2B antibody  >2 publications with LPXN and PTK2B
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >2 publications with LPXN and Immune System Diseases
 Necrosis Antibodies  >2 publications with LPXN and Necrosis
 Uterine Cervical Neoplasms Antibodies  >1 publications with LPXN and Uterine Cervical Neoplasms
 Chromosome Aberrations Antibodies  >1 publications with LPXN and Chromosome Aberrations
 Cell Transformation, Neoplastic Antibodies  >1 publications with LPXN and Cell Transformation, Neoplastic
 Inflammation Antibodies  >1 publications with LPXN and Inflammation
Organs/Tissues associated with anti-LPXN antibody
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >5 publications with LPXN and Prostate
 Bone Antibodies  >4 publications with LPXN and Bone
 Vascular Antibodies  >2 publications with LPXN and Vascular
 Blood Antibodies  >2 publications with LPXN and Blood
 Uterus Antibodies  >1 publications with LPXN and Uterus
 Bone Marrow Antibodies  >1 publications with LPXN and Bone Marrow
 Muscle Antibodies  >1 publications with LPXN and Muscle
 Skin Antibodies  >1 publications with LPXN and Skin
 Spleen Antibodies  >1 publications with LPXN and Spleen
 Uncharacterized Tissue Antibodies  >1 publications with LPXN and Uncharacterized Tissue
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