NP_002323.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31kDa/504kDa
NCBI Official Full Name
prolow-density lipoprotein receptor-related protein 1 preproprotein
NCBI Official Synonym Full Names
LDL receptor related protein 1
NCBI Official Synonym Symbols
APR; KPA; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R; IGFBP-3R; IGFBP3R1 [Similar Products]
NCBI Protein Information
prolow-density lipoprotein receptor-related protein 1
UniProt Protein Name
Prolow-density lipoprotein receptor-related protein 1
UniProt Synonym Protein Names
Alpha-2-macroglobulin receptor
UniProt Synonym Gene Names
NCBI Summary for LRP1
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
UniProt Comments for LRP1
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:11907044, PubMed:12888553, PubMed:12713657). Acts as an alpha-2-macroglobulin receptor (PubMed:26142438).
Research Articles on LRP1
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Products associated with anti-LRP1 antibody
Pathways associated with anti-LRP1 antibody
Diseases associated with anti-LRP1 antibody
Organs/Tissues associated with anti-LRP1 antibody
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