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anti-LRP2 antibody :: Rabbit anti-Human LRP2 / Megalin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240863
Immunohistochemistry (IHC)
Unit / Price
  DISCONTINUED
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LRP2 / Megalin, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human LRP2 / Megalin

 Product Synonym Names    Anti-LRP2 / Megalin Antibody IHC-plus; LRP2; DBS; Glycoprotein 330; gp330; Megalin; LRP-2; Calcium sensor protein; Human LRP2; Megalin
 Product Gene Name   

anti-LRP2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 600073
 3D Structure    ModBase 3D Structure for P98164
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Protein G Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human LRP2 / Megalin.
 Immunogen Type    Synthetic peptide
 Immunogen    LRP2 / Megalin antibody was raised against synthetic peptide from human LRP2 / Megalin.
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-LRP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LRP2 antibody

   Megalin or low density lipoprotein-related protein 2 (LRP2), is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithelial tissues such as the kidney. Megalin has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase.
 Applications Tested/Suitable for anti-LRP2 antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-LRP2 antibody    ELISA (1:000 - 1:1000), IHC-P (2.5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-LRP2 antibody    Anti-Megalin antibody IHC of human kidney cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-LRP2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for LRP2. It may not necessarily be applicable to this product.
 NCBI GI #    126012573
 NCBI GeneID    4036
 NCBI Accession #    NP_004516.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004525.2 [Other Products]
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 UniProt Primary Accession #    P98164 [Other Products]
 UniProt Secondary Accession #    O00711; Q16215 [Other Products]
 UniProt Related Accession #    P98164 [Other Products]
 Molecular Weight    521,958 Da
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 NCBI Official Full Name    low-density lipoprotein receptor-related protein 2
 NCBI Official Synonym Full Names    low density lipoprotein receptor-related protein 2
 NCBI Official Symbol    LRP2 [Similar Products]
 NCBI Official Synonym Symbols   
DBS; GP330
[Similar Products]
 NCBI Protein Information    low-density lipoprotein receptor-related protein 2; LRP-2; megalin; glycoprotein 330; calcium sensor protein; Heymann nephritis antigen homolog
 UniProt Protein Name    Low-density lipoprotein receptor-related protein 2
 UniProt Synonym Protein Names   
Glycoprotein 330; gp330; Megalin
 Protein Family    Low-density lipoprotein receptor-related protein
 UniProt Gene Name    LRP2 [Similar Products]
 UniProt Synonym Gene Names    LRP-2; gp330 [Similar Products]
 UniProt Entry Name    LRP2_HUMAN
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 NCBI Summary for LRP2    The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
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 UniProt Comments for LRP2    LRP2: Acts together with cubilin to mediate HDL endocytosis. May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release. Defects in LRP2 are the cause of Donnai-Barrow syndrome (DBS); also known as faciooculoacousticorenal syndrome (FOAR syndrome). DBS is a rare autosomal recessive disorder characterized by major malformations including agenesis of the corpus callosum, congenital diaphragmatic hernia, facial dysmorphology, ocular anomalies, sensorineural hearing loss and developmental delay. The FOAR syndrome was first described as comprising facial anomalies, ocular anomalies, sensorineural hearing loss, and proteinuria. DBS and FOAR were first described as distinct disorders but the classic distinguishing features between the 2 disorders were presence of proteinuria and absence of diaphragmatic hernia and corpus callosum anomalies in FOAR. Early reports noted that the 2 disorders shared many phenotypic features and may be identical. Although there is variability in the expression of some features (e.g. agenesis of the corpus callosum and proteinuria), DBS and FOAR are now considered to represent the same entity. Belongs to the LDLR family.

Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: Golgi apparatus; endocytic vesicle; lysosome; endoplasmic reticulum; brush border membrane; lysosomal membrane; apical plasma membrane; integral to membrane; plasma membrane; coated pit; receptor complex; endosome

Molecular Function: protein binding; calcium ion binding; SH3 domain binding

Biological Process: steroid metabolic process; phototransduction, visible light; cell proliferation; receptor-mediated endocytosis; forebrain development; protein amino acid glycosylation; endocytosis; lipid metabolic process; retinoid metabolic process; vitamin D metabolic process

Disease: Donnai-barrow Syndrome
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 Research Articles on LRP2    1. Transgenic/knock-out megalin-deficient mice develop anxiety behavior and impaired learning, as described in Alzheimer's disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LRP2 antibodyPathways associated with anti-LRP2 antibody
 Reference Product  PubMed Publications
 SHH antibody  >4 publications with LRP2 and SHH
 DAB2 antibody  >3 publications with LRP2 and DAB2
 CUBN antibody  >3 publications with LRP2 and CUBN
 LRPAP1 antibody  >2 publications with LRP2 and LRPAP1
 ALB antibody  >1 publications with LRP2 and ALB
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Steroid Hormones And Vitamin D Pathway antibodies  Metabolism Of Steroid Hormones And Vitamin D Pathway Diagram
 Retinoid Metabolism And Transport Pathway antibodies  Retinoid Metabolism And Transport Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling Events Mediated By The Hedgehog Family Pathway antibodies  Signaling Events Mediated By The Hedgehog Family Pathway Diagram
Diseases associated with anti-LRP2 antibodyOrgans/Tissues associated with anti-LRP2 antibody
 Disease Name  Pubmed Publications
 Proteinuria Antibodies  >16 publications with LRP2 and Proteinuria
 Kidney Diseases Antibodies  >13 publications with LRP2 and Kidney Diseases
 Disease Models, Animal Antibodies  >11 publications with LRP2 and Disease Models, Animal
 Hearing Loss, Sensorineural Antibodies  >7 publications with LRP2 and Hearing Loss, Sensorineural
 Weight Loss Antibodies  >7 publications with LRP2 and Weight Loss
 Hernia, Diaphragmatic Antibodies  >6 publications with LRP2 and Hernia, Diaphragmatic
 Donnai-Barrow syndrome Antibodies  >5 publications with LRP2 and Donnai-Barrow syndrome
 Cardiovascular Diseases Antibodies  >5 publications with LRP2 and Cardiovascular Diseases
 Inflammation Antibodies  >4 publications with LRP2 and Inflammation
 Fibrosis Antibodies  >4 publications with LRP2 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >41 publications with LRP2 and Kidney
 Brain Antibodies  >27 publications with LRP2 and Brain
 Eye Antibodies  >8 publications with LRP2 and Eye
 Liver Antibodies  >6 publications with LRP2 and Liver
 Embryonic Tissue Antibodies  >6 publications with LRP2 and Embryonic Tissue
 Thyroid Antibodies  >4 publications with LRP2 and Thyroid
 Spinal Cord Antibodies  >3 publications with LRP2 and Spinal Cord
 Muscle Antibodies  >2 publications with LRP2 and Muscle
 Skin Antibodies  >1 publications with LRP2 and Skin
 Lung Antibodies  >1 publications with LRP2 and Lung
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