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anti-LRRFIP1 antibody :: Rabbit anti-Human LRRFIP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151272
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LRRFIP1, Polyclonal Antibody

 Also Known As   

LRRFIP1 Antibody

 Product Synonym Names    LRRFIP1; GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1; GCF2; Leucine-rich repeat flightless-interacting protein 1; GC-binding factor 2; LRR FLII-interacting protein 1; leucine rich repeat (in FLII) interacting protein 1
 Product Gene Name   

anti-LRRFIP1 antibody

[Similar Products]
 Antibody/Peptide Pairs    LRRFIP1 peptide (MBS151970) is used for blocking the activity of LRRFIP1 antibody (MBS151272)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603256
 3D Structure    ModBase 3D Structure for Q32MZ4
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    LRRFIP1 antibody is predicted to not cross-react with other LRRFIP family members. Three isoforms of LRRFIP1 are known to exist; this antibody will only recognize the two longer isoforms.
 Purity/Purification    LRRFIP1 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    LRRFIP1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human LRRFIP1.
 Buffer    LRRFIP1 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    LRRFIP1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-LRRFIP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LRRFIP1 antibody

   LRRFIP1 Antibody: LRRFIP1, also known as GC-binding factor 2 (GCF2), is a 738 amino acid transcriptional repressor that mainly plays a cytoskeletal role. It is primarily localized in the cytoplasm and preferentially binds to GC-rich dsDNA, but will also bind directly to dsRNA as well. The RNA binding domain encompasses a lysine-rich motif. LRRFIP1 interacts with the mammalian Flightless I (Fli-I) and is a key component in the cytoskeletal regulation of platelet function. LRRFIP1 and the related protein LRRFIP2 may modulate canonical WNT signaling and mediate the IRF3-induced production of type I interferon via a beta-catenin-dependent pathway.
 Applications Tested/Suitable for anti-LRRFIP1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-LRRFIP1 antibody    LRRFIP1 antibody can be used for detection of LRRFIP1 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-LRRFIP1 antibody    Western blot analysis of LRRFIP1 in human colon tissue lysate with LRRFIP1 antibody at 1 μg/mL.
anti-LRRFIP1 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-LRRFIP1 antibody    Immunofluorescence of LRRFIP1 in human colon tissue with LRRFIP1 antibody at 20 μg/mL.
anti-LRRFIP1 antibody Immunofluorescence (IF) image
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 Immunohistochemistry (IHC) of anti-LRRFIP1 antibody    Immunohistochemistry of LRRFIP1 in human colon tissue with LRRFIP1 antibody at 5 μg/mL.
anti-LRRFIP1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for LRRFIP1. It may not necessarily be applicable to this product.
 NCBI GI #    212276096
 NCBI GeneID    9208
 NCBI Accession #    NP_001131022 [Other Products]
 NCBI GenBank Nucleotide #    NM_001137552.1 [Other Products]
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 UniProt Primary Accession #    Q32MZ4 [Other Products]
 UniProt Secondary Accession #    O75766; O75799; Q32MZ5; Q53T49; Q6PKG2; Q9Y607; E9PGZ2 [Other Products]
 UniProt Related Accession #    Q32MZ4 [Other Products]
 Molecular Weight    73,060 Da
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 NCBI Official Full Name    leucine-rich repeat flightless-interacting protein 1 isoform 3
 NCBI Official Synonym Full Names    leucine rich repeat (in FLII) interacting protein 1
 NCBI Official Symbol    LRRFIP1 [Similar Products]
 NCBI Official Synonym Symbols   
GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1
[Similar Products]
 NCBI Protein Information    leucine-rich repeat flightless-interacting protein 1; GC-binding factor 2; NEDD8-conjugating enzyme; TAR RNA-interacting protein; LRR FLII-interacting protein 1
 UniProt Protein Name    Leucine-rich repeat flightless-interacting protein 1
 UniProt Synonym Protein Names   
GC-binding factor 2; TAR RNA-interacting protein
 Protein Family    Leucine-rich repeat flightless-interacting protein
 UniProt Gene Name    LRRFIP1 [Similar Products]
 UniProt Synonym Gene Names    GCF2; TRIP; LRR FLII-interacting protein 1 [Similar Products]
 UniProt Entry Name    LRRF1_HUMAN
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 UniProt Comments for LRRFIP1    LRRFIP1: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. Belongs to the LRRFIP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: cytoskeleton; cytoplasm; plasma membrane; cytosol; nucleus

Molecular Function: protein binding; protein homodimerization activity; DNA binding; double-stranded RNA binding

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; positive regulation of interferon type I production; innate immune response; negative regulation of transcription, DNA-dependent
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 Research Articles on LRRFIP1    1. High GCF2 expression is associated with hepatoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LRRFIP1 antibodyPathways associated with anti-LRRFIP1 antibody
 Reference Product  PubMed Publications
 CTNNB1 antibody  >4 publications with LRRFIP1 and CTNNB1
 FLII antibody  >4 publications with LRRFIP1 and FLII
 SLC1A2 antibody  >2 publications with LRRFIP1 and SLC1A2
 MYD88 antibody  >2 publications with LRRFIP1 and MYD88
 TFAP2A antibody  >1 publications with LRRFIP1 and TFAP2A
 GRIP1 antibody  >1 publications with LRRFIP1 and GRIP1
 Products by Pathway  Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 LRR FLII-interacting Protein 1 (LRRFIP1) Activates Type I IFN Production Pathway antibodies  LRR FLII-interacting Protein 1 (LRRFIP1) Activates Type I IFN Production Pathway Diagram
 Signaling By FGFR In Disease Pathway antibodies  Signaling By FGFR In Disease Pathway Diagram
 Signaling By FGFR Mutants Pathway antibodies  Signaling By FGFR Mutants Pathway Diagram
 Signaling By FGFR1 Fusion Mutants Pathway antibodies  Signaling By FGFR1 Fusion Mutants Pathway Diagram
 Signaling By FGFR1 Mutants Pathway antibodies  Signaling By FGFR1 Mutants Pathway Diagram
Diseases associated with anti-LRRFIP1 antibodyOrgans/Tissues associated with anti-LRRFIP1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >8 publications with LRRFIP1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >3 publications with LRRFIP1 and Heart Diseases
 Nervous System Diseases Antibodies  >3 publications with LRRFIP1 and Nervous System Diseases
 Necrosis Antibodies  >3 publications with LRRFIP1 and Necrosis
 Liver Diseases Antibodies  >2 publications with LRRFIP1 and Liver Diseases
 Disease Models, Animal Antibodies  >2 publications with LRRFIP1 and Disease Models, Animal
 Inflammation Antibodies  >2 publications with LRRFIP1 and Inflammation
 Death Antibodies  >1 publications with LRRFIP1 and Death
 Breast Neoplasms Antibodies  >1 publications with LRRFIP1 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with LRRFIP1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with LRRFIP1 and Blood
 Heart Antibodies  >5 publications with LRRFIP1 and Heart
 Brain Antibodies  >5 publications with LRRFIP1 and Brain
 Muscle Antibodies  >3 publications with LRRFIP1 and Muscle
 Bone Antibodies  >2 publications with LRRFIP1 and Bone
 Liver Antibodies  >2 publications with LRRFIP1 and Liver
 Vascular Antibodies  >1 publications with LRRFIP1 and Vascular
 Connective Tissue Antibodies  >1 publications with LRRFIP1 and Connective Tissue
 Testis Antibodies  >1 publications with LRRFIP1 and Testis
 Bone Marrow Antibodies  >1 publications with LRRFIP1 and Bone Marrow
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