Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow LRRK2 rightarrow Polyclonal LRRK2  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Neurokinin B (NKB) ELISA Kit
 • PA2G4 Antibody
 • p14 ARF (CDKN2A) Antibody
 • Beta-2 adrenergic receptor (Adrb2) Recombinant Protein
 • tumor protein p53 (TP53) ELISA Kit
 • Phosphorylated tau 181 (p-Tau181) ELISA Kit
 • GTF2H2C Antibody
 • Noradrenaline (NE) ELISA Kit
 • Thyroid Stimulating Hormone (TSH) beta Antibody
 • Activating Transcription Factor 4 (ATF4) ELISA Kit
 • soluble OX40L (sOX40L) ELISA Kit
 • CX3CL1 ELISA Kit
 • Coiled Coil Domain Containing Protein 80 (CCDC80) ELISA Kit
 • SLC16A3 Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-LRRK2 antibody :: Rabbit LRRK2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2521286
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LRRK2, Polyclonal Antibody

★Popular Item★
 Also Known As   

LRRK2 Polyclonal Antibody

 Product Synonym Names    PARK8; RIPK7; ROCO2; AURA17; DARDARIN
 Product Gene Name   

anti-LRRK2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    168600
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Purity/Purification    Antigen affinity purification
 Concentration    1.1mg/mL (lot specific)
Section Bar
 Immunogen    Recombinant protein of human LRRK2
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Section Bar
 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-LRRK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-LRRK2 antibody

   This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.
 Product Categories/Family for anti-LRRK2 antibody    Neuroscience
 Applications Tested/Suitable for anti-LRRK2 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-LRRK2 antibody    IHC: 1:25-1:100
Section Bar
 Immunohistochemistry (IHC) of anti-LRRK2 antibody    Immunohistochemistry of paraffin-embedded Human liver cancer tissue using LRRK2 Polyclonal Antibody at dilution 1:30
anti-LRRK2 antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-LRRK2 antibody    Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using LRRK2 Polyclonal Antibody at dilution 1:30
anti-LRRK2 antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for LRRK2. It may not necessarily be applicable to this product.
 NCBI GI #    171846278
 NCBI GeneID    120892
 NCBI Accession #    NP_940980.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_198578.3 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q6ZS50; Q8NCX9; A6NJU2 [Other Products]
 UniProt Related Accession #    Q5S007 [Other Products]
 Molecular Weight    286,103 Da
Table BarTOPTable Bar
 NCBI Official Full Name    leucine-rich repeat serine/threonine-protein kinase 2
 NCBI Official Synonym Full Names    leucine-rich repeat kinase 2
 NCBI Official Symbol    LRRK2 [Similar Products]
 NCBI Official Synonym Symbols   
PARK8; RIPK7; ROCO2; AURA17; DARDARIN
[Similar Products]
 NCBI Protein Information    leucine-rich repeat serine/threonine-protein kinase 2; augmented in rheumatoid arthritis 17
 UniProt Protein Name    Leucine-rich repeat serine/threonine-protein kinase 2
 UniProt Synonym Protein Names   
Dardarin
 Protein Family    Leucine-rich repeat serine/threonine-protein kinase
 UniProt Gene Name    LRRK2 [Similar Products]
 UniProt Synonym Gene Names    PARK8 [Similar Products]
 UniProt Entry Name    LRRK2_HUMAN
Section Bar
 NCBI Summary for LRRK2    This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for LRRK2    LRRK2: a large multidomain protein kinase with a TKL-type kinase domain, multiple protein-protein interaction domains and a mitochondrial Rho domain (MIRO). May play a role in the etiology of Parkinson disease. May also have GTPase activity. Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Interacts with PARK2, PRDX3 and TPCN2. Expressed throughout the adult brain, but at a lower level than in heart and liver. Expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas. Defects in LRRK2 are the cause of Parkinson disease type 8 (PARK8). A slowly progressive neurodegenerative disorder characterized by bradykinesia, rigidity, resting tremor, postural instability, neuronal loss in the substantia nigra, and the presence of neurofibrillary MAPT (tau)-positive and Lewy bodies in some patients.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, TKL; TKL group; LRRK family

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: dendrite cytoplasm; Golgi apparatus; extracellular space; neuron projection; mitochondrion; synaptic vesicle membrane; endoplasmic reticulum; lysosome; dendrite; terminal button; perikaryon; trans-Golgi network; inclusion body; cytosol; lipid raft; mitochondrial outer membrane; cell soma; mitochondrial matrix; axon; mitochondrial membrane; cytoplasm; mitochondrial inner membrane; plasma membrane; cytoplasmic vesicle; cell junction; endosome

Molecular Function: GTPase activity; tubulin binding; identical protein binding; clathrin binding; GTP-dependent protein kinase activity; protein homodimerization activity; Rho GTPase binding; GTP binding; actin binding; GTPase activator activity; protein kinase activity; MAP kinase kinase activity; protein serine/threonine kinase activity; SNARE binding; protein binding; protein kinase A binding; syntaxin-1 binding; kinase activity; glycoprotein binding; ATP binding

Biological Process: regulation of synaptic transmission, glutamatergic; activation of MAPKK activity; positive regulation of protein binding; activation of MAPK activity; protein amino acid autophosphorylation; regulation of neuron maturation; determination of adult life span; protein amino acid phosphorylation; positive regulation of MAP kinase activity; tangential migration from the subventricular zone to the olfactory bulb; negative regulation of protein amino acid phosphorylation; small GTPase mediated signal transduction; regulation of dopamine receptor signaling pathway; negative regulation of protein binding; regulation of mitochondrial depolarization; neuromuscular junction development; positive regulation of autophagy; positive regulation of dopamine receptor signaling pathway; olfactory bulb development; peptidyl-threonine phosphorylation; MAPKKK cascade; endocytosis; regulation of locomotion; peptidyl-serine phosphorylation; regulation of membrane potential; positive regulation of programmed cell death; positive regulation of protein ubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; intracellular distribution of mitochondria; autophagy; positive regulation of protein amino acid phosphorylation; response to oxidative stress; regulation of excitatory postsynaptic membrane potential; neurite morphogenesis; positive regulation of GTPase activity

Disease: Parkinson Disease 8, Autosomal Dominant
Table BarTOPTable Bar
 Research Articles on LRRK2    1. This manuscript provides a detailed assessment of the possible functions of each of the six putative domains of LRRK2, and how their structure and function may be affected by Parkinsonism-associated variations.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-LRRK2 antibodyPathways associated with anti-LRRK2 antibody
 Reference Product  PubMed Publications
 PARK2 antibody  >910 publications with LRRK2 and PARK2
 SNCA antibody  >138 publications with LRRK2 and SNCA
 MKKS antibody  >3 publications with LRRK2 and MKKS
 EIF2C2 antibody  >2 publications with LRRK2 and EIF2C2
 STUB1 antibody  >2 publications with LRRK2 and STUB1
 CDC37 antibody  >1 publications with LRRK2 and CDC37
 DVL1 antibody  >1 publications with LRRK2 and DVL1
 MSN antibody  >1 publications with LRRK2 and MSN
 Products by Pathway  Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
 Wnt Signaling Pathway And Pluripotency antibodies  Wnt Signaling Pathway And Pluripotency Diagram
Diseases associated with anti-LRRK2 antibodyOrgans/Tissues associated with anti-LRRK2 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >958 publications with LRRK2 and Nervous System Diseases
 Parkinson Disease Antibodies  >953 publications with LRRK2 and Parkinson Disease
 Movement Disorders Antibodies  >934 publications with LRRK2 and Movement Disorders
 Neurodegenerative Diseases Antibodies  >932 publications with LRRK2 and Neurodegenerative Diseases
 Parkinsonian Disorders Antibodies  >906 publications with LRRK2 and Parkinsonian Disorders
 Death Antibodies  >114 publications with LRRK2 and Death
 Disease Models, Animal Antibodies  >100 publications with LRRK2 and Disease Models, Animal
 Nerve Degeneration Antibodies  >42 publications with LRRK2 and Nerve Degeneration
 Inflammation Antibodies  >27 publications with LRRK2 and Inflammation
 PARKINSON DISEASE 8, AUTOSOMAL DOMINANT Antibodies  >23 publications with LRRK2 and PARKINSON DISEASE 8, AUTOSOMAL DOMINANT
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >345 publications with LRRK2 and Brain
 Nerve Antibodies  >76 publications with LRRK2 and Nerve
 Blood Antibodies  >49 publications with LRRK2 and Blood
 Kidney Antibodies  >19 publications with LRRK2 and Kidney
 Eye Antibodies  >13 publications with LRRK2 and Eye
 Skin Antibodies  >9 publications with LRRK2 and Skin
 Lung Antibodies  >8 publications with LRRK2 and Lung
 Embryonic Tissue Antibodies  >7 publications with LRRK2 and Embryonic Tissue
 Bone Antibodies  >5 publications with LRRK2 and Bone
 Liver Antibodies  >5 publications with LRRK2 and Liver
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions