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anti-LYZ antibody :: Rabbit LYZ / Lysozyme Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS246897
Immunohistochemistry (IHC)
Unit / Price
0.25 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LYZ / Lysozyme, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Polyclonal (IgG) to Human LYZ / Lysozyme

 Product Synonym Names    Anti-LYZ / Lysozyme Antibody IHC-plus; LYZ; 1;4-beta-N-acetylmuramidase C; LZM; Lysozyme; Lysozyme (renal amyloidosis); Renal amyloidosis; Lysozyme C; Human LYZ; Lysozyme
 Product Gene Name   

anti-LYZ antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 153450
 3D Structure    ModBase 3D Structure for P61626
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Baboon, Cat, Dog, Human, Monkey, Pig
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 Purity/Purification    Purified
 Form/Format    10mM PBS, pH 7.4, with 0.2% BSA and 0.09% Sodium Azide
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 Target Species    Human
 Non Reactive Species    Mouse, Rat
 Immunogen Description    Human lysozyme purified from the urine of patients with monocytic leukemia.
 Immunogen Species    LYZ/Lysozyme antibody was raised against Human.
 Immunogen    LYZ / Lysozyme antibody was raised against human lysozyme purified from the urine of patients with monocytic leukemia.
 POSITIVE CONTROL    Tonsil, colon, or skin.
 CELLULAR LOCALIZATION    Cytoplasmic
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 Preparation and Storage    +4 degree C, avoid freezing
 Other Notes    Small volumes of anti-LYZ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-LYZ antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-LYZ antibody    IHC-P (1:100)
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 Immunohistochemistry (IHC) of anti-LYZ antibody    Anti-Lysozyme antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
anti-LYZ antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for LYZ. It may not necessarily be applicable to this product.
 NCBI GI #    4557894
 NCBI GeneID    4069
 NCBI Accession #    NP_000230.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000239.2 [Other Products]
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 UniProt Primary Accession #    P61626 [Other Products]
 UniProt Secondary Accession #    P00695; Q13170; Q9UCF8 [Other Products]
 UniProt Related Accession #    P61626 [Other Products]
 Molecular Weight    16,537 Da
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 NCBI Official Full Name    lysozyme C
 NCBI Official Synonym Full Names    lysozyme
 NCBI Official Symbol    LYZ [Similar Products]
 NCBI Official Synonym Symbols   
LZM
[Similar Products]
 NCBI Protein Information    lysozyme C; c-type lysozyme; 1,4-beta-N-acetylmuramidase C
 UniProt Protein Name    Lysozyme C
 UniProt Synonym Protein Names   
1,4-beta-N-acetylmuramidase C
 UniProt Gene Name    LYZ [Similar Products]
 UniProt Synonym Gene Names    LZM [Similar Products]
 UniProt Entry Name    LYSC_HUMAN
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 NCBI Summary for LYZ    This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]
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 UniProt Comments for LYZ    LYZ: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents. Defects in LYZ are a cause of amyloidosis type 8 (AMYL8); also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. Belongs to the glycosyl hydrolase 22 family.

Protein type: Hydrolase; Secreted; EC 3.2.1.17; Endoplasmic reticulum; Vesicle; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: extracellular space; extracellular region

Molecular Function: identical protein binding; lysozyme activity

Biological Process: retinal homeostasis; metabolic process; cytolysis; defense response to bacterium; inflammatory response

Disease: Amyloidosis, Familial Visceral
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 Research Articles on LYZ    1. Both mRNA and protein levels of lysozyme were significantly higher in patients with biofilm associated chronic rhinosinusitis (CRS) than those with CRS and no biofilm and controls.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LYZ antibodyPathways associated with anti-LYZ antibody
 Reference Product  PubMed Publications
 LTF antibody  >3 publications with LYZ and LTF
 GSN antibody  >1 publications with LYZ and GSN
 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Salivary Secretion Pathway antibodies  Salivary Secretion Pathway Diagram
 Salivary Secretion Pathway antibodies  Salivary Secretion Pathway Diagram
Diseases associated with anti-LYZ antibodyOrgans/Tissues associated with anti-LYZ antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >11 publications with LYZ and Inflammation
 Cardiovascular Diseases Antibodies  >7 publications with LYZ and Cardiovascular Diseases
 Necrosis Antibodies  >7 publications with LYZ and Necrosis
 Disease Models, Animal Antibodies  >5 publications with LYZ and Disease Models, Animal
 Atherosclerosis Antibodies  >3 publications with LYZ and Atherosclerosis
 Heart Diseases Antibodies  >2 publications with LYZ and Heart Diseases
 Neoplasms, Experimental Antibodies  >2 publications with LYZ and Neoplasms, Experimental
 Kidney Diseases Antibodies  >2 publications with LYZ and Kidney Diseases
 Fibrosis Antibodies  >2 publications with LYZ and Fibrosis
 Lung Diseases Antibodies  >2 publications with LYZ and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >29 publications with LYZ and Blood
 Bone Antibodies  >7 publications with LYZ and Bone
 Liver Antibodies  >7 publications with LYZ and Liver
 Heart Antibodies  >7 publications with LYZ and Heart
 Vascular Antibodies  >7 publications with LYZ and Vascular
 Intestine Antibodies  >7 publications with LYZ and Intestine
 Kidney Antibodies  >6 publications with LYZ and Kidney
 Lymph Node Antibodies  >4 publications with LYZ and Lymph Node
 Muscle Antibodies  >4 publications with LYZ and Muscle
 Stomach Antibodies  >3 publications with LYZ and Stomach
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