AAB24877.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
lactoferrin
NCBI Official Synonym Full Names
lactotransferrin
NCBI Protein Information
lactotransferrin; talalactoferrin; OTTHUMP00000209779; OTTHUMP00000209780; OTTHUMP00000209781; neutrophil lactoferrin; growth-inhibiting protein 12
UniProt Protein Name
Lactotransferrin
UniProt Synonym Protein Names
Talalactoferrin
UniProt Synonym Gene Names
UniProt Entry Name
TRFL_HUMAN
NCBI Summary for LTF
This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
UniProt Comments for LTF
Function: Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. Ref.21Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration. Ref.21Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors. Ref.21The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Ref.21
Catalytic activity: Preferential at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin.
Subunit structure: Monomer.
Subcellular location: Secreted.
Sequence similarities: Belongs to the transferrin family.Contains 2 transferrin-like domains.
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Products associated with anti-LTF antibody
Pathways associated with anti-LTF antibody
Diseases associated with anti-LTF antibody
Organs/Tissues associated with anti-LTF antibody
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