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anti-LTF antibody :: Rabbit Lactoferrin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS316070 anti-LTF antibody
Unit / Price
1.5 mL  /  $335 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lactoferrin (LTF), Polyclonal Antibody

 Also Known As   

Rabbit anti Human Lactoferrin

 Product Synonym Names    Rabbit Antibody to Human Lactoferrin
 Product Gene Name   

anti-LTF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (46477496..46506395, complement). Location: 3p21.31
 OMIM    150210
 3D Structure    ModBase 3D Structure for P02788
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 Clonality    Polyclonal
 Host    Rabbit
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 Specificity    Lactoferrin
Based on immunoelectrophoresis, the antibody reacts with human lactoferrin found in human milk. No antibody was detected against other milk or serum proteins, but antibodies may cross-react with lactoferrin from other species.
 Purity/Purification    Isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads
 Form/Format    HRP, Lyophilized
Reconstitute with 1.5ml distilled water. Centrifuge product if it is not completely clear after standing for 1-2 hours at room temperature. To judge clarity, draw product into a pasteur pipette.
 Concentration    0.8mg/ml (prior to lyophilization) (lot specific)
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 Immunogen    Lactoferrin purified from human colostrum
 Buffer    Lyophilized from 0.01M Sodium phosphate, 0.25M Sodium chloride, pH 7.6 containing 15mg/ml BSA (IgG and Protease free)
 Preservative    No
 Lyophilized    Yes
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
 Warnings    Use of sodium azide as a preservative will substantially inhibit the enzyme activity of horseradish peroxidase.
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 Preparation and Storage    Store lyophilized product at 2 to 8 degree C. After reconstitution, aliquot and store at -70 degree C or below. Prepare working dilution only prior to immediate use. For long-term storage after reconstitution, we suggest the addition of an equal volume of
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-LTF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-LTF antibody    Polyclonal Antibodies to Proteins and Bioactive Peptides
 Application Notes for anti-LTF antibody    A dilution range of 1:500 - 1:5,000 is suggested for immunohistochemistry on tissue sections, 1:5,000 - 1:100,000 for ELISA and Western blotting with chromogenic substrates and 1:10,000 - 1:200,000 for Western blotting with ECL substrates. Each laboratory
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NCBI/Uniprot data below describe general gene information for LTF. It may not necessarily be applicable to this product.
 NCBI GI #    263312
 NCBI GeneID    4057
 NCBI Accession #    AAB24877.1 [Other Products]
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 UniProt Primary Accession #    P02788 [Other Products]
 UniProt Secondary Accession #    O00756; Q16780; Q16785; Q16786; Q16789; Q8IU92; Q8IZH6; Q8TCD2; Q96KZ4; Q96KZ5; Q9H1Z3 [Other Products]
 UniProt Related Accession #    P02788; Q19KS2; Q2TUW9; Q5DSM0; Q5EK51; Q8IWS6; Q8IX02 [Other Products]
 Molecular Weight    78,182 Da [Similar Products]
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 NCBI Official Full Name    lactoferrin
 NCBI Official Synonym Full Names    lactotransferrin
 NCBI Official Symbol    LTF [Similar Products]
 NCBI Official Synonym Symbols   
LF; HLF2; GIG12
[Similar Products]
 NCBI Protein Information    lactotransferrin; talalactoferrin; OTTHUMP00000209779; OTTHUMP00000209780; OTTHUMP00000209781; neutrophil lactoferrin; growth-inhibiting protein 12
 UniProt Protein Name    Lactotransferrin
 UniProt Synonym Protein Names   
Talalactoferrin
 Protein Family    Lactotransferrin
 UniProt Gene Name    LTF [Similar Products]
 UniProt Synonym Gene Names    LF [Similar Products]
 UniProt Entry Name    TRFL_HUMAN
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 NCBI Summary for LTF    This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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 UniProt Comments for LTF    Function: Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. Ref.21Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration. Ref.21Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors. Ref.21The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Ref.21

Catalytic activity: Preferential at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin.

Subunit structure: Monomer.

Subcellular location: Secreted.

Sequence similarities: Belongs to the transferrin family.Contains 2 transferrin-like domains.
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 Research Articles on LTF    1. Fecal lactoferrin has a high positive and negative predictive value for the diagnosis of small bowel Crohn's disease, detected by capsule endoscopy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LTF antibodyPathways associated with anti-LTF antibody
 Reference Product  PubMed Publications
 LYZ antibody  >1 publications with LTF and LYZ
 CD14 antibody  >1 publications with LTF and CD14
 CEBPD antibody  >1 publications with LTF and CEBPD
 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
Diseases associated with anti-LTF antibodyOrgans/Tissues associated with anti-LTF antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >27 publications with LTF and Neoplasms
 Carcinoma Antibodies  >16 publications with LTF and Carcinoma
 Skin Diseases Antibodies  >15 publications with LTF and Skin Diseases
 Inflammation Antibodies  >13 publications with LTF and Inflammation
 Protozoan Infections Antibodies  >12 publications with LTF and Protozoan Infections
 Cardiovascular Diseases Antibodies  >11 publications with LTF and Cardiovascular Diseases
 Drug Toxicity Antibodies  >9 publications with LTF and Drug Toxicity
 Vascular Diseases Antibodies  >9 publications with LTF and Vascular Diseases
 Bacterial Infections Antibodies  >8 publications with LTF and Bacterial Infections
 Mycoses Antibodies  >7 publications with LTF and Mycoses
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >89 publications with LTF and Blood
 Brain Antibodies  >62 publications with LTF and Brain
 Muscle Antibodies  >45 publications with LTF and Muscle
 Skin Antibodies  >13 publications with LTF and Skin
 Lung Antibodies  >12 publications with LTF and Lung
 Uterus Antibodies  >10 publications with LTF and Uterus
 Eye Antibodies  >7 publications with LTF and Eye
 Liver Antibodies  >6 publications with LTF and Liver
 Kidney Antibodies  >6 publications with LTF and Kidney
 Spleen Antibodies  >5 publications with LTF and Spleen
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