NP_006142.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
lactoperoxidase isoform 1 preproprotein
NCBI Official Synonym Full Names
lactoperoxidase
NCBI Official Synonym Symbols
NCBI Protein Information
lactoperoxidase
UniProt Protein Name
Lactoperoxidase
UniProt Synonym Protein Names
Salivary peroxidase; SPO
UniProt Synonym Gene Names
UniProt Entry Name
PERL_HUMAN
NCBI Summary for LPO
This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
UniProt Comments for LPO
LPO: May contribute to airway host defense against infection. Belongs to the peroxidase family. XPO subfamily.
Protein type: Secreted; EC 1.11.1.7; Oxidoreductase; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 17q23.1
Cellular Component: basolateral plasma membrane; cytoplasm; extracellular space
Molecular Function: heme binding; metal ion binding
Biological Process: defense response to bacterium; detection of chemical stimulus involved in sensory perception of bitter taste; hydrogen peroxide catabolic process; response to oxidative stress; thiocyanate metabolic process
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Products associated with anti-LPO antibody
Pathways associated with anti-LPO antibody
Diseases associated with anti-LPO antibody
Organs/Tissues associated with anti-LPO antibody
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