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anti-EPM2A antibody :: Goat Laforin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421876
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Laforin (EPM2A), Polyclonal Antibody

 Also Known As   

Goat anti-Laforin (isoform a) Antibody

 Product Synonym Names    Goat Anti-Laforin (isoform a), Biotinylated Antibody; epilepsy, progressive myoclonus type 2, Lafora disease (laforin); laforin; EPM2A; epilepsy, progressive myoclonus type 2A, Lafora disease (laforin); EPM2; MELF; epilepsy; progressive myoclonus type 2; Lafora disease (laforin) antibody; laforin antibody; EPM2A antibody; epilepsy; progressive myoclonus type 2A; Lafora disease (laforin) antibody; EPM2 antibody; MELF antibody; Laforin; Laforin (isoform a)
 Product Gene Name   

anti-EPM2A antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: Laforin (MBS421876)
Biotin Conjugated Antibody: Laforin (MBS423503)
 Antibody/Peptide Pairs    Laforin peptide (MBS425621) is used for blocking the activity of Laforin antibody (MBS421876)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    EATGHTNEMK HTTD
 OMIM    254780
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-EATGHTNEMKHTTD, from the internal region of the protein sequence according to NP_005661.1.
 Epitope    Internal region
 Note    This antibody is expected to recognize isoform a (NP_005661.1) only.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-EPM2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-EPM2A antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-EPM2A antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Immunohistochemistry: In paraffin embedded Human Cerebellum shows pixulate staining in the cells of the granular layer. Recommended concentration, 2.5-3.8ug/ml.
Western Blot: Approx.38kDa band observed in Human Brain (Cerebellum), Mouse Brain and Rat Brain lysates (calculated MW of 37.2kDa according to NP_005661.1). Recommended concentration: 0.1-0.3ug/ml.
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 Western Blot (WB) of anti-EPM2A antibody    (0.1ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-EPM2A antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-EPM2A antibody    (3.8ug/ml) staining of paraffin embedded Human Cerebellum. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-EPM2A antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for EPM2A. It may not necessarily be applicable to this product.
 NCBI GI #    11321613
 NCBI GeneID    7957
 NCBI Accession #    NP_005661.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005670.3 [Other Products]
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 UniProt Secondary Accession #    O95483; Q5T3F5; Q6IS15; Q8IU96; Q8IX24; Q8IX25; Q9BS66; Q9UEN2; B3KMU5; B4DRZ2 [Other Products]
 UniProt Related Accession #    O95278; B3EWF7 [Other Products]
 Molecular Weight    35,169 Da
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 NCBI Official Full Name    laforin isoform a
 NCBI Official Synonym Full Names    epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
 NCBI Official Symbol    EPM2A [Similar Products]
 NCBI Official Synonym Symbols   
EPM2; MELF
[Similar Products]
 NCBI Protein Information    laforin
 UniProt Protein Name    Laforin
 UniProt Synonym Protein Names   
Glucan phosphatase; Lafora PTPase; LAFPTPase
 Protein Family    Laforin
 UniProt Gene Name    EPM2A [Similar Products]
 UniProt Synonym Gene Names    LAFPTPase [Similar Products]
 UniProt Entry Name    EPM2A_HUMAN
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 NCBI Summary for EPM2A    This gene encodes a dual-specificity phosphatase that associates with polyribosomes. The encoded protein may be involved in the regulation of glycogen metabolism. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EPM2A    laforin: Dual specificity protein phosphatase. May be involved in the control of glycogen metabolism, particularly in monitoring for and preventing the formation of poorly branched glycogen molecules (polyglucosans). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Forms a complex with NHLRC1/malin and HSP70 and this complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Isoform 2, an inactive phosphatase, could function as a dominant-negative regulator for the phosphatase activity of isoform 1. Defects in EPM2A are a cause of progressive myoclonic epilepsy type 2 (EPM2); also known as Lafora disease. EPM2 is an autosomal recessive and severe form of adolescent-onset progressive epilepsy. Typically, as seizures increase in frequency, cognitive function declines towards dementia, and affected individuals die usually within 10 years after onset. EPM2 occurs worldwide, but it is particularly common in the mediterranean countries of southern Europe and northern Africa, in southern India and in the Middle East. At the cellular level, it is characterized by accumulation of starch-like polyglucosans called Lafora bodies (LBs) that are most abundant in organs with the highest glucose metabolism: brain, heart, liver and skeletal muscle. Among other conditions involving polyglucosans, EPM2 is unique in that the inclusions are in neuronal dendrites but not axons and the forming polyglucosan fibrils are associated with the endoplasmic reticulum. Belongs to the protein-tyrosine phosphatase family. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, dual-specificity; EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6q24

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; nucleus; plasma membrane; polysome

Molecular Function: carbohydrate phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity

Biological Process: autophagy; glycogen biosynthetic process; glycogen metabolic process; habituation; negative regulation of TOR signaling pathway; nervous system development; positive regulation of macroautophagy; protein amino acid dephosphorylation

Disease: Myoclonic Epilepsy Of Lafora
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 Research Articles on EPM2A    1. laforin is responsible for glycogen dephosphorylation during exercise and acts during the cytosolic degradation of glycogen
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-EPM2A antibodyPathways associated with anti-EPM2A antibody
 Reference Product  PubMed Publications
 NHLRC1 antibody  >99 publications with EPM2A and NHLRC1
 PPP1R3C antibody  >7 publications with EPM2A and PPP1R3C
 GSK3B antibody  >3 publications with EPM2A and GSK3B
 NFU1 antibody  >2 publications with EPM2A and NFU1
 GYS1 antibody  >1 publications with EPM2A and GYS1
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Carbohydrate Metabolism Pathway antibodies  Diseases Of Carbohydrate Metabolism Pathway Diagram
 Diseases Of Metabolism Pathway antibodies  Diseases Of Metabolism Pathway Diagram
 Glucose Metabolism Pathway antibodies  Glucose Metabolism Pathway Diagram
 Glycogen Storage Diseases Pathway antibodies  Glycogen Storage Diseases Pathway Diagram
 Glycogen Synthesis Pathway antibodies  Glycogen Synthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram
 Myoclonic Epilepsy Of Lafora Pathway antibodies  Myoclonic Epilepsy Of Lafora Pathway Diagram
Diseases associated with anti-EPM2A antibodyOrgans/Tissues associated with anti-EPM2A antibody
 Disease Name  Pubmed Publications
 Lafora Disease Antibodies  >429 publications with EPM2A and Lafora Disease
 Nervous System Diseases Antibodies  >376 publications with EPM2A and Nervous System Diseases
 Brain Diseases Antibodies  >372 publications with EPM2A and Brain Diseases
 Myoclonic Epilepsies, Progressive Antibodies  >289 publications with EPM2A and Myoclonic Epilepsies, Progressive
 Neurodegenerative Diseases Antibodies  >244 publications with EPM2A and Neurodegenerative Diseases
 Musculoskeletal Diseases Antibodies  >23 publications with EPM2A and Musculoskeletal Diseases
 Brain Diseases, Metabolic Antibodies  >20 publications with EPM2A and Brain Diseases, Metabolic
 Liver Diseases Antibodies  >13 publications with EPM2A and Liver Diseases
 Neurobehavioral Manifestations Antibodies  >9 publications with EPM2A and Neurobehavioral Manifestations
 Movement Disorders Antibodies  >8 publications with EPM2A and Movement Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >169 publications with EPM2A and Brain
 Skin Antibodies  >79 publications with EPM2A and Skin
 Muscle Antibodies  >77 publications with EPM2A and Muscle
 Liver Antibodies  >49 publications with EPM2A and Liver
 Heart Antibodies  >27 publications with EPM2A and Heart
 Eye Antibodies  >9 publications with EPM2A and Eye
 Kidney Antibodies  >4 publications with EPM2A and Kidney
 Thyroid Antibodies  >3 publications with EPM2A and Thyroid
 Vascular Antibodies  >2 publications with EPM2A and Vascular
 Prostate Antibodies  >1 publications with EPM2A and Prostate
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