CAA62596.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,819 Da
NCBI Official Full Name
laminin alpha 4
NCBI Official Synonym Full Names
laminin subunit alpha 4
NCBI Protein Information
laminin subunit alpha-4
UniProt Protein Name
Laminin subunit alpha-4
UniProt Synonym Protein Names
Laminin-14 subunit alpha; Laminin-8 subunit alpha; Laminin-9 subunit alpha
NCBI Summary for LAMa4
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]
UniProt Comments for LAMa4
LAMA4: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Extracellular matrix; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: basal lamina; basement membrane; extracellular matrix; extracellular region
Molecular Function: extracellular matrix structural constituent; protein binding
Biological Process: extracellular matrix organization and biogenesis
Disease: Cardiomyopathy, Dilated, 1jj
Research Articles on LAMa4
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Products associated with anti-LAMa4 antibody
Pathways associated with anti-LAMa4 antibody
Diseases associated with anti-LAMa4 antibody
Organs/Tissues associated with anti-LAMa4 antibody
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