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anti-LAMC3 antibody :: Rabbit anti-Human, Mouse Laminin gamma-3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2539366
Western Blot (WB)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Laminin gamma-3 (LAMC3), Polyclonal Antibody

★Popular Item★
 Also Known As   

Laminin gamma-3 Polyclonal Antibody

 Product Synonym Names    LAMC3; Laminin subunit gamma-3; Laminin-12 subunit gamma; Laminin-14 subunit gamma; Laminin-15 subunit gamma
 Product Gene Name   

anti-LAMC3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604349
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from the C-terminal region of human Laminin gamma-3.
 Buffer    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-LAMC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-LAMC3 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-LAMC3 antibody    WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-1:100, ELISA: 1:5000-1:20000
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 Western Blot (WB) of anti-LAMC3 antibody    Western Blot analysis of SH-SY5Y cells using Laminin ?-3 Polyclonal Antibody at dilution of 1:1000.
anti-LAMC3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for LAMC3. It may not necessarily be applicable to this product.
 NCBI GI #    110611156
 NCBI GeneID    10319
 NCBI Accession #    NP_006050.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_006059.3 [Other Products]
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 UniProt Secondary Accession #    Q59H72; B1APX9; B1APY0 [Other Products]
 UniProt Related Accession #    Q9Y6N6 [Other Products]
 Molecular Weight    Calculated MW: 172
Observed MW: 170
[Similar Products]
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 NCBI Official Full Name    laminin subunit gamma-3
 NCBI Official Synonym Full Names    laminin subunit gamma 3
 NCBI Official Symbol    LAMC3 [Similar Products]
 NCBI Official Synonym Symbols   
OCCM
[Similar Products]
 NCBI Protein Information    laminin subunit gamma-3
 UniProt Protein Name    Laminin subunit gamma-3
 UniProt Synonym Protein Names   
Laminin-12 subunit gamma; Laminin-14 subunit gamma; Laminin-15 subunit gamma
 Protein Family    Laminin
 UniProt Gene Name    LAMC3 [Similar Products]
 UniProt Entry Name    LAMC3_HUMAN
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 NCBI Summary for LAMC3    Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 3. The gamma 3 chain is most similar to the gamma 1 chain, and contains all the 6 domains expected of the gamma chain. It is a component of laminin 12. The gamma 3 chain is broadly expressed in skin, heart, lung, and the reproductive tracts. In skin, it is seen within the basement membrane of the dermal-epidermal junction at points of nerve penetration. Gamma 3 is also a prominent element of the apical surface of ciliated epithelial cells of lung, oviduct, epididymis, ductus deferens, and seminiferous tubules. The distribution of gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. [provided by RefSeq, Aug 2011]
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 UniProt Comments for LAMC3    LAMC3: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Defects in LAMC3 are the cause of cortical malformations occipital (OCCM). OCCM is a disease in which affected individuals develop seizures, sometimes associated with transient visual changes. Brain MRI shows both pachygyria and polymicrogyria restricted to the lateral occipital lobes.

Protein type: Motility/polarity/chemotaxis; Extracellular matrix; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9q34.12

Cellular Component: basement membrane; extracellular region; membrane; proteinaceous extracellular matrix

Molecular Function: structural molecule activity

Biological Process: astrocyte development; cell adhesion; cellular morphogenesis during differentiation; extracellular matrix organization and biogenesis; retina development in camera-type eye; visual perception

Disease: Cortical Malformations, Occipital
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 Research Articles on LAMC3    1. These data suggest that beta2 and gamma3-containing laminins play an important dose-dependent role in development of the cortical pial basement membrane
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LAMC3 antibodyPathways associated with anti-LAMC3 antibody
 Reference Product  PubMed Publications
 LAMC1 antibody  >2 publications with LAMC3 and LAMC1
 LAMC2 antibody  >2 publications with LAMC3 and LAMC2
 LAMB2 antibody  >2 publications with LAMC3 and LAMB2
 LAMA2 antibody  >1 publications with LAMC3 and LAMA2
 LAMA5 antibody  >1 publications with LAMC3 and LAMA5
 LAMB1 antibody  >1 publications with LAMC3 and LAMB1
 ITGB1 antibody  >1 publications with LAMC3 and ITGB1
 LAMB3 antibody  >1 publications with LAMC3 and LAMB3
 LAMA3 antibody  >1 publications with LAMC3 and LAMA3
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Laminin Interactions Pathway antibodies  Laminin Interactions Pathway Diagram
 Non-integrin Membrane-ECM Interactions Pathway antibodies  Non-integrin Membrane-ECM Interactions Pathway Diagram
Diseases associated with anti-LAMC3 antibodyOrgans/Tissues associated with anti-LAMC3 antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >3 publications with LAMC3 and Mental Disorders
 Child Development Disorders, Pervasive Antibodies  >2 publications with LAMC3 and Child Development Disorders, Pervasive
 Skin Diseases Antibodies  >1 publications with LAMC3 and Skin Diseases
 Nervous System Diseases Antibodies  >1 publications with LAMC3 and Nervous System Diseases
 Central Nervous System Diseases Antibodies  >1 publications with LAMC3 and Central Nervous System Diseases
 Hydrocephalus Antibodies  >1 publications with LAMC3 and Hydrocephalus
 Breast Neoplasms Antibodies  >1 publications with LAMC3 and Breast Neoplasms
 Neurobehavioral Manifestations Antibodies  >1 publications with LAMC3 and Neurobehavioral Manifestations
 Brain Diseases Antibodies  >1 publications with LAMC3 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with LAMC3 and Brain
 Eye Antibodies  >6 publications with LAMC3 and Eye
 Testis Antibodies  >5 publications with LAMC3 and Testis
 Heart Antibodies  >2 publications with LAMC3 and Heart
 Lung Antibodies  >2 publications with LAMC3 and Lung
 Embryonic Tissue Antibodies  >2 publications with LAMC3 and Embryonic Tissue
 Placenta Antibodies  >2 publications with LAMC3 and Placenta
 Uterus Antibodies  >1 publications with LAMC3 and Uterus
 Mouth Antibodies  >1 publications with LAMC3 and Mouth
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