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anti-LAMC2 antibody :: EHS Sarcoma Laminin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS674557 anti-LAMC2 antibody
Unit / Price
1 mg  /  $215 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Laminin (LAMC2), Polyclonal Antibody

 Also Known As   

Mouse Laminin

 Product Synonym Names    Mouse Laminin
 Product Gene Name   

anti-LAMC2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (183155174..183214262). Location: 1q25-q31
 3D Structure    ModBase 3D Structure for Q13753
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 Clonality    Polyclonal
 Host    EHS Sarcoma
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 Purity/Purification    Purity: >95% as judged by SDS-PAGE analysis.
Purification: The extract is purified by salt precipitation, ion exchange and gel filtration chromatography.
 Form/Format    Purified protein
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 Characterization    To insure lot-to-lot consistency, each batch of product is tested to conform to the characteristics of a standard reference reagent using SDS-PAGE, Western Blot and ELISA methods.
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 Preparation and Storage    The purified protein is supplied as a 1 mg/mL solution in 1 mL of 0.4M NaCl, 0.05M Tris-HCl, pH 7.4, containing protease inhibitors. Store at 2-8 degree C.
Reagents are stable for the period shown on the label if stored as directed.
 Other Notes    Small volumes of anti-LAMC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Application Notes for anti-LAMC2 antibody    Research Application(s): Laminin standard
Antigen for antibody production
Coating material for cell culture studies
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NCBI/Uniprot data below describe general gene information for LAMC2. It may not necessarily be applicable to this product.
 NCBI GI #    34232
 NCBI GeneID    3918
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 UniProt Primary Accession #    Q13753 [Other Products]
 UniProt Related Accession #    Q13753; Q2M1N2 [Other Products]
 Molecular Weight    121,634 Da [Similar Products]
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 NCBI Official Full Name    Laminin
 NCBI Official Synonym Full Names    laminin, gamma 2
 NCBI Official Symbol    LAMC2 [Similar Products]
 NCBI Official Synonym Symbols   
B2T; CSF; EBR2; BM600; EBR2A; LAMB2T; LAMNB2; MGC138491; MGC141938
[Similar Products]
 NCBI Protein Information    laminin subunit gamma-2; BM600-100kDa; nicein-100kDa; kalinin-105kDa; kalinin (105kD); ladsin (140kDa); nicein (100kDa); laminin B2t chain; OTTHUMP00000033550; OTTHUMP00000230852; CSF 140 kDa subunit; nicein subunit gamma; kalinin subunit gamma; ladsin 140 kDa subunit; epiligrin subunit gamma; laminin-5 subunit gamma; cell-scattering factor 140 kDa subunit; large adhesive scatter factor 140 kDa subunit
 UniProt Protein Name    Laminin, gamma 2
 Protein Family    Laminin
 UniProt Gene Name    LAMC2 [Similar Products]
 UniProt Entry Name    Q2M1N2_HUMAN
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 NCBI Summary for LAMC2    Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. [provided by RefSeq]
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 UniProt Comments for LAMC2    LAMC2: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell- scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells. Defects in LAMC2 are a cause of epidermolysis bullosa junctional Herlitz type (H-JEB); also known as junctional epidermolysis bullosa Herlitz-Pearson type. JEB defines a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement membrane. H-JEB is a severe, infantile and lethal form. Death occurs usually within the first six months of life. Occasionally, children survive to teens. H-JEB is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Extracellular matrix; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q25-q31

Cellular Component: extracellular space; laminin-5 complex; laminin-2 complex; membrane; perinuclear region of cytoplasm; extracellular region; cell cortex

Molecular Function: heparin binding

Biological Process: extracellular matrix disassembly; hemidesmosome assembly; epidermis development; extracellular matrix organization and biogenesis; cell adhesion

Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type; Epidermolysis Bullosa, Junctional, Herlitz Type
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Product References and Citations for anti-LAMC2 antibody

   1). Timpl, R., Rohde, H., Risteli, L., Ott, U., Robey, P. G., Martin, G. R. 1982. Meth. Enzymol. 82:838.
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 Research Articles on LAMC2    1. These results suggest that epigenetic activation of LAMB3 and LAMC2 may play an important role in gastric carcinogenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LAMC2 antibodyPathways associated with anti-LAMC2 antibody
 Reference Product  PubMed Publications
 LAMB3 antibody  >48 publications with LAMC2 and LAMB3
 COL7A1 antibody  >3 publications with LAMC2 and COL7A1
 BMP1 antibody  >1 publications with LAMC2 and BMP1
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Inflammatory Response Pathway antibodies  Inflammatory Response Pathway Diagram
Diseases associated with anti-LAMC2 antibodyOrgans/Tissues associated with anti-LAMC2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >98 publications with LAMC2 and Neoplasms
 Carcinoma Antibodies  >82 publications with LAMC2 and Carcinoma
 Skin Diseases Antibodies  >53 publications with LAMC2 and Skin Diseases
 Genetic Diseases, Inborn Antibodies  >46 publications with LAMC2 and Genetic Diseases, Inborn
 Congenital Abnormalities Antibodies  >45 publications with LAMC2 and Congenital Abnormalities
 Carcinoma, Squamous Cell Antibodies  >41 publications with LAMC2 and Carcinoma, Squamous Cell
 Neoplasm Invasiveness Antibodies  >38 publications with LAMC2 and Neoplasm Invasiveness
 Head and Neck Neoplasms Antibodies  >31 publications with LAMC2 and Head and Neck Neoplasms
 Adenocarcinoma Antibodies  >28 publications with LAMC2 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >52 publications with LAMC2 and Skin
 Mouth Antibodies  >21 publications with LAMC2 and Mouth
 Lung Antibodies  >13 publications with LAMC2 and Lung
 Lymph Node Antibodies  >10 publications with LAMC2 and Lymph Node
 Embryonic Tissue Antibodies  >9 publications with LAMC2 and Embryonic Tissue
 Bone Antibodies  >7 publications with LAMC2 and Bone
 Nerve Antibodies  >7 publications with LAMC2 and Nerve
 Liver Antibodies  >7 publications with LAMC2 and Liver
 Stomach Antibodies  >6 publications with LAMC2 and Stomach
 Eye Antibodies  >6 publications with LAMC2 and Eye
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