P18424.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
49,727 Da
NCBI Official Full Name
Phosphatidylcholine-sterol acyltransferase
NCBI Official Synonym Full Names
lecithin cholesterol acyltransferase
NCBI Protein Information
phosphatidylcholine-sterol acyltransferase
UniProt Protein Name
Phosphatidylcholine-sterol acyltransferase
UniProt Synonym Protein Names
Lecithin-cholesterol acyltransferase
NCBI Summary for LCAT
enzyme involved in the metabolism of plasma lipoproteins [RGD, Feb 2006]
UniProt Comments for LCAT
Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107, PubMed:14636062).
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Products associated with anti-LCAT antibody
Pathways associated with anti-LCAT antibody
Organs/Tissues associated with anti-LCAT antibody
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