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anti-LEP-R antibody :: Rabbit anti-Human Leptin Receptor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS853003
Testing Data
Unit / Price
0.1 mg  /  $330 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Leptin Receptor (LEP-R), Polyclonal Antibody

 Also Known As   

Leptin Receptor Antibody

 Product Gene Name   

anti-LEP-R antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601007
 3D Structure    ModBase 3D Structure for P48357
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Purified by protein A column containing 0.02% NaN3
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 Preparation and Storage    Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C.
 Other Notes    Small volumes of anti-LEP-R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-LEP-R antibody

   Rabbit polyclonal Lepti Receptor (1) antibody was raised against a 14 amino acid peptide at the intermediate residues of human Leptin Receptor protein.
 Product Categories/Family for anti-LEP-R antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-LEP-R antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-LEP-R antibody    Peptide ELISA: 1:40,000-1:80,000
WB: 1:500-1:1,000
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 Testing Data of anti-LEP-R antibody    anti-LEP-R antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for LEP-R. It may not necessarily be applicable to this product.
 NCBI GI #    51093379
 NCBI GeneID    3953
 NCBI Accession #    NP_001003679.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001003679.3 [Other Products]
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 UniProt Primary Accession #    P48357 [Other Products]
 UniProt Secondary Accession #    Q13592; Q13593; Q13594; Q92919; Q92920; Q92921 [Other Products]
 UniProt Related Accession #    P48357 [Other Products]
 Molecular Weight    96,042 Da
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 NCBI Official Full Name    leptin receptor isoform 3
 NCBI Official Synonym Full Names    leptin receptor
 NCBI Official Symbol    LEPR [Similar Products]
 NCBI Official Synonym Symbols   
OBR; OB-R; CD295; LEP-R; LEPRD
[Similar Products]
 NCBI Protein Information    leptin receptor
 UniProt Protein Name    Leptin receptor
 UniProt Synonym Protein Names   
HuB219; OB receptor; OB-R; CD_antigen: CD295
 Protein Family    Leptin receptor
 UniProt Gene Name    LEPR [Similar Products]
 UniProt Synonym Gene Names    DB; OBR; LEP-R; OB-R [Similar Products]
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 NCBI Summary for LEP-R    The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]
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 UniProt Comments for LEP-R    Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones () (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production ().
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Product References and Citations for anti-LEP-R antibody

   (1)Koda, M., Sulkowska, M., Wincewicz, A. et, al Expression of leptin, leptin receptor, and hypoxia-inducible factor 1 alpha in human endometrial cancer. Ann. N. Y. Acad. Sci. 2007: 1095, 90-98.
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 Research Articles on LEP-R    1. Studied adiponectin (ADIPOQ), leptin (LEP), leptin receptor (LEPR), and resistin (RETN) single nucleotide polymorphisms and their association in obesity. Results showed that ADIPOQ 4522C<T and 276G<T, LEP 2548G<A, and RETN 420C<G polymorphisms were associated with obesity risk in Hammam Sousse Sahloul Heart Study (HSHS) population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LEP-R antibodyPathways associated with anti-LEP-R antibody
 Reference Product  PubMed Publications
 LEP antibody  >135 publications with LEP-R and LEP
 STAT3 antibody  >36 publications with LEP-R and STAT3
 JAK2 antibody  >9 publications with LEP-R and JAK2
 SOCS3 antibody  >3 publications with LEP-R and SOCS3
 APOD antibody  >2 publications with LEP-R and APOD
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Leptin Signaling Pathway antibodies  Leptin Signaling Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with anti-LEP-R antibodyOrgans/Tissues associated with anti-LEP-R antibody
 Disease Name  Pubmed Publications
 Peripheral Nervous System Diseases Antibodies  >396 publications with LEP-R and Peripheral Nervous System Diseases
 Drug Toxicity Antibodies  >335 publications with LEP-R and Drug Toxicity
 Obesity Antibodies  >299 publications with LEP-R and Obesity
 Overweight Antibodies  >211 publications with LEP-R and Overweight
 Diabetes Mellitus Antibodies  >182 publications with LEP-R and Diabetes Mellitus
 Inflammation Antibodies  >177 publications with LEP-R and Inflammation
 Neoplasms Antibodies  >146 publications with LEP-R and Neoplasms
 Necrosis Antibodies  >101 publications with LEP-R and Necrosis
 Diabetes Mellitus, Type 2 Antibodies  >98 publications with LEP-R and Diabetes Mellitus, Type 2
 Cardiovascular Diseases Antibodies  >96 publications with LEP-R and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >1378 publications with LEP-R and Skin
 Nerve Antibodies  >660 publications with LEP-R and Nerve
 Muscle Antibodies  >211 publications with LEP-R and Muscle
 Liver Antibodies  >206 publications with LEP-R and Liver
 Eye Antibodies  >178 publications with LEP-R and Eye
 Bone Antibodies  >149 publications with LEP-R and Bone
 Connective Tissue Antibodies  >124 publications with LEP-R and Connective Tissue
 Vascular Antibodies  >117 publications with LEP-R and Vascular
 Brain Antibodies  >104 publications with LEP-R and Brain
 Adipose Tissue Antibodies  >102 publications with LEP-R and Adipose Tissue
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