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anti-LXRb antibody :: Rabbit Liver X Receptor Beta Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2033736 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $185 +1 FREE 8GB USB
0.1 mg  /  $230 +1 FREE 8GB USB
0.2 mg  /  $345 +1 FREE 8GB USB
1 mg  /  $825 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Liver X Receptor Beta (LXRb), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Liver X Receptor Beta (LXRb)

 Product Synonym Names    NR1-H2; UNR; LXR-B; NER; NER-I; RIP15; Nuclear Receptor Subfamily 1,Group H,Member 2; Ubiquitously-Expressed Nuclear Receptor; Oxysterols receptor LXR-beta
 Product Gene Name   

anti-LXRb antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2033736 Technical Datasheet    Technical Datasheet PDF
 3D Structure    ModBase 3D Structure for Q60644
 Clonality    Polyclonal
 Host    Rabbit
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 Purity/Purification    Antigen-specific affinity chromatography followed by Protein A affinity chromatography
 Form/Format    Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300,50% glycerol.
 Concentration    0.47mg/ml (lot specific)
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 Organism Species    Mus musculus(Mouse)
 Source    Polyclonal antibody preparation
 Traits    Liquid
 Immunogen    Recombinant LXRb (Met1~Glu446) expressed in E.coli
 Conjugated Antibody    The APC-Cy7 conjugated antibody version of this item is also available as catalog #MBS2070177
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 4║C for frequent use.
Aliquot and store at -20║C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37░C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of anti-LXRb antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-LXRb antibody   


 Application Notes for anti-LXRb antibody    Western blotting: 0.5-2)Ug/mL;1:230-900
Immunohistochemistry: 5-20) Ug/mL;1:23-90
Immunocytochemistry: 5-20)Ug/mL;1:23-90

Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-LXRb antibody    (Western Blot; Sample: Mouse Liver lysate; Primary Ab: 1ug/ml Rabbit Anti-Mouse LXRb Antibody Second Ab: 0.2ug/mLáHRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody )
anti-LXRb antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-LXRb antibody    (Figure. Western Blot; Sample: Recombinant LXRb, Mouse)
anti-LXRb antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-LXRb antibody    (Used in DAB staining on formalin fixed paraffin- embedded liver tissue)
anti-LXRb antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for LXRb. It may not necessarily be applicable to this product.
 NCBI GI #    550822384
 NCBI GeneID    22260
 NCBI Accession #    NP_001272446.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001285517.1 [Other Products]
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 UniProt Primary Accession #    Q60644 [Other Products]
 UniProt Related Accession #    Q60644 [Other Products]
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 NCBI Official Full Name    oxysterols receptor LXR-beta isoform a
 NCBI Official Synonym Full Names    nuclear receptor subfamily 1, group H, member 2
 NCBI Official Symbol    Nr1h2 [Similar Products]
 NCBI Official Synonym Symbols   
UR; LXR; Unr; LXRB; NER1; OR-1; Unr2; RIP15; LXRBSV; LXRbeta; AI194859
[Similar Products]
 NCBI Protein Information    oxysterols receptor LXR-beta
 UniProt Protein Name    Oxysterols receptor LXR-beta
 UniProt Synonym Protein Names   
Liver X receptor beta; Nuclear receptor subfamily 1 group H member 2; Retinoid X receptor-interacting protein No.15; Ubiquitously-expressed nuclear receptor
 UniProt Gene Name    Nr1h2 [Similar Products]
 UniProt Synonym Gene Names    Lxrb; Rip15; Unr; Unr2 [Similar Products]
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 UniProt Comments for LXRb    LXR-beta: Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Forms a heterodimer with RXR. Ubiquitous. Belongs to the nuclear hormone receptor family. NR1 subfamily.

Protein type: Nuclear receptor

Chromosomal Location of Human Ortholog: 7|7 B3

Cellular Component: cytoplasm; nucleus

Molecular Function: apolipoprotein A-I receptor binding; ATPase binding; DNA binding; DNA binding transcription factor activity; ligand-dependent nuclear receptor activity; metal ion binding; protein binding; retinoid X receptor binding; sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding

Biological Process: cellular lipid metabolic process; cholesterol homeostasis; lipid homeostasis; negative regulation of cholesterol storage; negative regulation of gene expression; negative regulation of lipid transport; negative regulation of pinocytosis; negative regulation of proteolysis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of cellular protein metabolic process; positive regulation of cholesterol efflux; positive regulation of cholesterol transport; positive regulation of fatty acid biosynthetic process; positive regulation of gene expression; positive regulation of high-density lipoprotein particle assembly; positive regulation of lipid storage; positive regulation of lipoprotein lipase activity; positive regulation of pancreatic juice secretion; positive regulation of secretion of lysosomal enzymes; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; positive regulation of triglyceride biosynthetic process; regulation of cholesterol homeostasis; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; retinoic acid receptor signaling pathway; steroid hormone mediated signaling; transcription, DNA-dependent
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 Research Articles on LXRb    1. PANDER strongly impacts hepatic lipid metabolism across metabolic states and may induce a selective hepatic insulin resistant phenotype via the LXR pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-LXRb antibodyDiseases associated with anti-LXRb antibody
 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >6 publications with LXRb and Fatty Liver
 Nervous System Diseases Antibodies  >5 publications with LXRb and Nervous System Diseases
 Hypercholesterolemia Antibodies  >4 publications with LXRb and Hypercholesterolemia
 Liver Diseases Antibodies  >4 publications with LXRb and Liver Diseases
 Atherosclerosis Antibodies  >4 publications with LXRb and Atherosclerosis
 Dyslipidemias Antibodies  >3 publications with LXRb and Dyslipidemias
 Hyperlipidemias Antibodies  >2 publications with LXRb and Hyperlipidemias
 Inflammation Antibodies  >2 publications with LXRb and Inflammation
 Drug Toxicity Antibodies  >1 publications with LXRb and Drug Toxicity
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with LXRb and Prenatal Exposure Delayed Effects
Organs/Tissues associated with anti-LXRb antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >37 publications with LXRb and Liver
 Brain Antibodies  >6 publications with LXRb and Brain
 Pancreas Antibodies  >3 publications with LXRb and Pancreas
 Kidney Antibodies  >2 publications with LXRb and Kidney
 Skin Antibodies  >2 publications with LXRb and Skin
 Bladder Antibodies  >1 publications with LXRb and Bladder
 Ovary Antibodies  >1 publications with LXRb and Ovary
 Intestine Antibodies  >1 publications with LXRb and Intestine
 Heart Antibodies  >1 publications with LXRb and Heart
 Lung Antibodies  >1 publications with LXRb and Lung
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