Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow LDLR rightarrow Polyclonal LDLR  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • lactotransferrin (LTF) ELISA Kit
 • CD136 (RON) (CD136 (RON)) Antibody
 • HIST1H1T Antibody
 • Glucocorticoid (GC) ELISA Kit
 • Growth Hormone (hGH) >=70% Pure, Human (GH1) Native Protein
 • Agouti Related Protein (AgRP) ELISA Kit
 • Carbohydrate Antigen 125 (CA125) ELISA Kit
 • GP Antibody
 • B-lymphocyte antigen CD20 (MS4A1) ELISA Kit
 • TNNC1 Antibody
 • Calumenin Recombinant Protein
 • Pleiotrophin (PTN) ELISA Kit
 • BLZF1 Antibody
 • 26S protease regulatory subunit 8 (Pros45) Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-LDLR antibody :: Rabbit Low Density Lipoprotein Receptor (LDLR) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2050414 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) anti-LDLR antibody
Unit / Price
0.01 mg  /  $135 +1 FREE 8GB USB
0.02 mg  /  $165 +1 FREE 8GB USB
0.05 mg  /  $245 +1 FREE 8GB USB
0.1 mg  /  $325 +1 FREE 8GB USB
0.2 mg  /  $505 +1 FREE 8GB USB
1 mg  /  $1,215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Low Density Lipoprotein Receptor (LDLR), Polyclonal Antibody

★Popular Item★
 Also Known As   

APC-Linked Polyclonal Antibody to Low Density Lipoprotein Receptor (LDLR)

 Product Synonym Names    FH; FHC; Familial Hypercholesterolemia
 Product Gene Name   

anti-LDLR antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: Low Density Lipoprotein Receptor (MBS2027252)
APC-CY7 Conjugated Antibody: Low Density Lipoprotein Receptor (LDLR) (MBS2050414)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 MBS2050414 Technical Datasheet    Technical Datasheet PDF
 OMIM    L00352
Section Bar
 Clonality    Polyclonal
 Host    Rabbit
Section Bar
 Purity/Purification    Antigen-specific Affinity Chromatography
 Form/Format    Supplied as solution form in 0.01M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
 Concentration    0.26 mg/ml (lot specific)
Section Bar
 Organism Species    Rattus norvegicus (Rat)
 Source    Antibody labeling
 Label    APC
 Traits    Liquid
 Immunogen    Recombinant LDLR (Ile335~Ile588) expressed in E.coli.
 Unconjugated Antibody    The unconjugated antibody version of this item is also available as catalog #MBS2027252
Section Bar
 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 4C for frequent use.
Aliquot and store at -20C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-LDLR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-LDLR antibody   

Western Blot(WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation(IP).

 Application Notes for anti-LDLR antibody    Western blotting: 0.5-2 ug/mL;1:130-520
Immunohistochemistry: 5-20 ug/mL;1:13-52
Immunocytochemistry: 5-20 ug/mL;1:13-52

Optimal working dilutions must be determined by end user.
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for LDLR. It may not necessarily be applicable to this product.
 NCBI GI #    307121
 NCBI GeneID    3949
 NCBI Accession #    AAA56833.1 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q53ZD9; Q59FQ1; Q9UDH7; B4DII3; B4DJZ8; B4DR00; B4DTQ3; C0JYY8; H0YLU8; H0YNT7 [Other Products]
 UniProt Related Accession #    P01130 [Other Products]
Table BarTOPTable Bar
 NCBI Official Full Name    low density lipoprotein receptor
 NCBI Official Synonym Full Names    low density lipoprotein receptor
 NCBI Official Symbol    LDLR [Similar Products]
 NCBI Official Synonym Symbols   
FH; FHC; LDLCQ2
[Similar Products]
 NCBI Protein Information    low-density lipoprotein receptor
 UniProt Protein Name    Low-density lipoprotein receptor
 Protein Family    Low-density lipoprotein receptor
 UniProt Gene Name    LDLR [Similar Products]
 UniProt Synonym Gene Names    LDL receptor [Similar Products]
Section Bar
 NCBI Summary for LDLR    The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Section Bar
 UniProt Comments for LDLR    LDLR: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR are the cause of familial hypercholesterolemia (FH); a common autosomal semi- dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis). Belongs to the LDLR family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: apical part of cell; basolateral plasma membrane; cell surface; coated pit; early endosome; endosome membrane; external side of plasma membrane; Golgi apparatus; integral to plasma membrane; late endosome; lysosome; membrane; plasma membrane; receptor complex

Molecular Function: clathrin heavy chain binding; glycoprotein binding; identical protein binding; low-density lipoprotein binding; low-density lipoprotein receptor activity; protease binding; protein binding; very-low-density lipoprotein receptor activity

Biological Process: cholesterol absorption; cholesterol homeostasis; cholesterol transport; endocytosis; lipid metabolic process; phospholipid transport; receptor-mediated endocytosis

Disease: Hypercholesterolemia, Familial
Table BarTOPTable Bar
 Research Articles on LDLR    1. LDLR A(+)A(+) genotype, ApoB X(+) allele and ApoE E4 allele increased the risk of premature coronary artery disease by 1.8, 2.1 and 12.1 respectively.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-LDLR antibodyPathways associated with anti-LDLR antibody
 Reference Product  PubMed Publications
 APOE antibody  >468 publications with LDLR and APOE
 APOB antibody  >364 publications with LDLR and APOB
 PCSK9 antibody  >246 publications with LDLR and PCSK9
 LDLRAP1 antibody  >25 publications with LDLR and LDLRAP1
 LIPC antibody  >14 publications with LDLR and LIPC
 MYLIP antibody  >10 publications with LDLR and MYLIP
 DAB1 antibody  >3 publications with LDLR and DAB1
 LRPAP1 antibody  >3 publications with LDLR and LRPAP1
 APOH antibody  >1 publications with LDLR and APOH
 Products by Pathway  Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
Diseases associated with anti-LDLR antibodyOrgans/Tissues associated with anti-LDLR antibody
 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >945 publications with LDLR and Atherosclerosis
 Cardiovascular Diseases Antibodies  >838 publications with LDLR and Cardiovascular Diseases
 Hypercholesterolemia Antibodies  >740 publications with LDLR and Hypercholesterolemia
 Dyslipidemias Antibodies  >735 publications with LDLR and Dyslipidemias
 Hyperlipidemias Antibodies  >687 publications with LDLR and Hyperlipidemias
 HYPERCHOLESTEROLEMIA, FAMILIAL Antibodies  >488 publications with LDLR and HYPERCHOLESTEROLEMIA, FAMILIAL
 Hyperlipoproteinemia Type II Antibodies  >354 publications with LDLR and Hyperlipoproteinemia Type II
 Inflammation Antibodies  >230 publications with LDLR and Inflammation
 Coronary Artery Disease Antibodies  >227 publications with LDLR and Coronary Artery Disease
 Coronary Disease Antibodies  >226 publications with LDLR and Coronary Disease
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1053 publications with LDLR and Blood
 Liver Antibodies  >587 publications with LDLR and Liver
 Vascular Antibodies  >509 publications with LDLR and Vascular
 Heart Antibodies  >275 publications with LDLR and Heart
 Bone Antibodies  >188 publications with LDLR and Bone
 Muscle Antibodies  >169 publications with LDLR and Muscle
 Bone Marrow Antibodies  >158 publications with LDLR and Bone Marrow
 Brain Antibodies  >124 publications with LDLR and Brain
 Kidney Antibodies  >69 publications with LDLR and Kidney
 Ovary Antibodies  >57 publications with LDLR and Ovary
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions