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anti-PRG4 antibody :: Goat Lubricin/PRG4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422087 anti-PRG4 antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lubricin/PRG4, Polyclonal Antibody

 Also Known As   

Goat anti-Lubricin/PRG4 Antibody

 Product Synonym Names    PRG4; proteoglycan 4; CACP; FLJ32635; HAPO; JCAP; MSF; SZP; bG174L6.2; Jacobs camptodactyly-arthropathy-pericarditis syndrome; articular superficial zone protein; bG174L6.2 (MSF: megakaryocyte stimulating factor); camptodactyly, arthropathy, coxa vara,; PRG4 antibody; proteoglycan 4 antibody; CACP antibody; FLJ32635 antibody; HAPO antibody; JCAP antibody; MSF antibody; SZP antibody; bG174L6.2 antibody; Jacobs camptodactyly-arthropathy-pericarditis syndrome antibody; articular superficial zone protein antibody; bG174L6.2 (MSF: megakaryocyte stimulating factor) antibody; camptodactyly; arthropathy; coxa vara; pericarditis syndrome antibody; lubricin antibody; megakaryocyte stimulating factor antibody; proteoglycan 4; (megakaryocyte stimulating factor; articular superficial zone protein; camptodactyly; arthropathy; coxa vara; pericarditis syndrome) antibody; Lubricin; Lubricin / PRG4
 Product Gene Name   

anti-PRG4 antibody

[Similar Products]
 Antibody/Peptide Pairs    Lubricin / PRG4 peptide (MBS425914) is used for blocking the activity of Lubricin/PRG4 antibody (MBS422087)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    DYESFCAEVH NP
 OMIM    208250
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence DYESFCAEVHNP, from the internal region of the protein sequence according to NP_005798.2.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-PRG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PRG4 antibody   

Peptide ELISA (EIA)

 Application Notes for anti-PRG4 antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Preliminary experiments in Human Bone Marrow lysates gave no specific signal but low background (at antibody concentration up to 0.3ug/ml).
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NCBI/Uniprot data below describe general gene information for PRG4. It may not necessarily be applicable to this product.
 NCBI GI #    67190163
 NCBI GeneID    10216
 NCBI Accession #    NP_005798.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005807.3 [Other Products]
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 UniProt Secondary Accession #    Q6DNC4; Q6DNC5; Q6ZMZ5; Q9BX49 [Other Products]
 UniProt Related Accession #    Q92954 [Other Products]
 Molecular Weight    146,468 Da
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 NCBI Official Full Name    proteoglycan 4 isoform A
 NCBI Official Synonym Full Names    proteoglycan 4
 NCBI Official Symbol    PRG4 [Similar Products]
 NCBI Official Synonym Symbols   
MSF; SZP; CACP; HAPO; JCAP
[Similar Products]
 NCBI Protein Information    proteoglycan 4
 UniProt Protein Name    Proteoglycan 4
 UniProt Synonym Protein Names   
Lubricin; Megakaryocyte-stimulating factor; Superficial zone proteoglycan
 Protein Family    Proteoglycan
 UniProt Gene Name    PRG4 [Similar Products]
 UniProt Synonym Gene Names    MSF; SZP [Similar Products]
 UniProt Entry Name    PRG4_HUMAN
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 NCBI Summary for PRG4    The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
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 UniProt Comments for PRG4    PRG4: Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Defects in PRG4 are the cause of camptodactyly- arthropathy-coxa vara-pericarditis syndrome (CACP); also known as Jacobs syndrome. CACP is an autosomal recessive disorder. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure associated with noninflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q25-q31

Cellular Component: extracellular region

Molecular Function: polysaccharide binding; scavenger receptor activity

Biological Process: cell proliferation; immune response; receptor-mediated endocytosis

Disease: Camptodactyly-arthropathy-coxa Vara-pericarditis Syndrome
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 Research Articles on PRG4    1. no synovial fluid level differences detected between healthy knees and injured knees
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-PRG4 antibodyOrgans/Tissues associated with anti-PRG4 antibody
 Disease Name  Pubmed Publications
 Pericarditis Antibodies  >14 publications with PRG4 and Pericarditis
 Inflammation Antibodies  >8 publications with PRG4 and Inflammation
 Disease Models, Animal Antibodies  >7 publications with PRG4 and Disease Models, Animal
 Necrosis Antibodies  >7 publications with PRG4 and Necrosis
 Jacobs syndrome Antibodies  >6 publications with PRG4 and Jacobs syndrome
 Hyperplasia Antibodies  >4 publications with PRG4 and Hyperplasia
 Lung Diseases Antibodies  >3 publications with PRG4 and Lung Diseases
 Contracture Antibodies  >3 publications with PRG4 and Contracture
 Hypertrophy Antibodies  >2 publications with PRG4 and Hypertrophy
 Nervous System Diseases Antibodies  >2 publications with PRG4 and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >18 publications with PRG4 and Connective Tissue
 Vascular Antibodies  >6 publications with PRG4 and Vascular
 Embryonic Tissue Antibodies  >5 publications with PRG4 and Embryonic Tissue
 Eye Antibodies  >5 publications with PRG4 and Eye
 Liver Antibodies  >4 publications with PRG4 and Liver
 Lung Antibodies  >4 publications with PRG4 and Lung
 Heart Antibodies  >3 publications with PRG4 and Heart
 Adipose Tissue Antibodies  >2 publications with PRG4 and Adipose Tissue
 Brain Antibodies  >2 publications with PRG4 and Brain
 Thymus Antibodies  >1 publications with PRG4 and Thymus
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