Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow LY86 rightarrow Polyclonal LY86  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • 14-3-3 beta - alpha (YWHAB) Antibody
 • Pneumolysin (ply) Recombinant Protein
 • NNMT Antibody
 • Apolipoprotein B (APOB) ELISA Kit
 • alpha-Galactosidase (alphaGAL) ELISA Kit
 • deoxyuridinetriphate (DUTP) ELISA Kit
 • Potassium channel toxin alpha-KTx 21.1 Recombinant Protein
 • HIS-TAG PROTEIN Purification Kit
 • CD123 Antibody
 • Immunoglobulin G Native Protein
 • VASA-DDX4 Antibody
 • Helicobacter pylori antibody (IgG) ELISA Kit
 • SORBS1-Ponsin Antibody
 • KRT14 Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-LY86 antibody :: Rabbit Lymphocyte antigen 86/MD-1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS395990
Western Blot/Blotting
Unit / Price
0.1 mg  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lymphocyte antigen 86/MD-1 (LY86), Polyclonal Antibody

 Also Known As   

Lymphocyte antigen 86 (IN)/MD-1

 Product Synonym Names    MD-1 (IN): Lymphocyte antigen 86
 Product Gene Name   

anti-LY86 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 6; NC_000006.11 (6588934..6655216). Location: 6p25.1
 OMIM    605241
 3D Structure    ModBase 3D Structure for O95711
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Purity/Purification    Antigen Immunoaffiinity Purification
 Form/Format    Provided as solution in phosphate buffered saline with 0.02% sodium azide
Section Bar
 Immunogen    Rabbit polyclonal MD-1 antibody was raised against a 15 amino acid peptide from near the center of human MD-1.
 Positive Control    May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression. Highly expressed in B-cells, monocytes and tonsil.5
Section Bar
 Preparation and Storage    Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
 Other Notes    Small volumes of anti-LY86 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-LY86 antibody

   Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins such as RP105, a recently identified homolog of TLR4. This protein, in association with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway. While MD-2 can directly bind to LPS, one of the activating molecules of TLR4, the function of MD-1 is less well-known. It has been suggested however, that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes.
 Product Categories/Family for anti-LY86 antibody    Polyclonal Antibody; Growth Factors & Receptors
 Applications Tested/Suitable for anti-LY86 antibody   

Western Blot (WB)

Section Bar
 Western Blot/Blotting of anti-LY86 antibody    Western blot analysis of MD-1 in Daudi cell lysate with MD-1 antibody at (A) 1 and (B) 2 g/ml.
anti-LY86 antibody Western Blot/Blotting (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for LY86. It may not necessarily be applicable to this product.
 NCBI GI #    4758708
 NCBI GeneID    9450
 NCBI Accession #    NP_004262.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004271.3 [Other Products]
Section Bar
 UniProt Primary Accession #    O95711 [Other Products]
 UniProt Secondary Accession #    Q9UQC4 [Other Products]
 UniProt Related Accession #    O95711 [Other Products]
 Molecular Weight    17.9 kD [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    lymphocyte antigen 86
 NCBI Official Synonym Full Names    lymphocyte antigen 86
 NCBI Official Symbol    LY86 [Similar Products]
 NCBI Official Synonym Symbols   
MD-1; MMD-1; dJ80N2.1; RP1-80N2.1
[Similar Products]
 NCBI Protein Information    lymphocyte antigen 86; ly-86; protein MD-1; MD-1, RP105-associated
 UniProt Protein Name    Lymphocyte antigen 86
 UniProt Synonym Protein Names   
Protein MD-1
 Protein Family    Lymphocyte antigen
 UniProt Gene Name    LY86 [Similar Products]
 UniProt Synonym Gene Names    MD1; Ly-86 [Similar Products]
 UniProt Entry Name    LY86_HUMAN
Section Bar
 UniProt Comments for LY86    Function: May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression

By similarity.

Subunit structure: M-shaped tetramer of two CD180-LY86 heterodimers. Ref.6

Subcellular location: Secreted › extracellular space. Note: Associated with CD180 at the cell surface.

Tissue specificity: Highly expressed in B-cells, monocytes and tonsil.

Induction: In monocytes, down-regulated by the cell-wall fraction of Mycobacterium bovis (BCG-CWS).

Sequence caution: The sequence BAA76410.1 differs from that shown. Reason: Erroneous initiation.
Table BarTOPTable Bar
 Research Articles on LY86    1. MD-1 may be a disease susceptibility gene for adult asthma in a Southern Han population in China.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-LY86 antibodyPathways associated with anti-LY86 antibody
 Reference Product  PubMed Publications
 TLR4 antibody  >19 publications with LY86 and TLR4
 CD180 antibody  >10 publications with LY86 and CD180
 CD14 antibody  >9 publications with LY86 and CD14
 LY96 antibody  >8 publications with LY86 and LY96
 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Toll Like Receptor 4 (TLR4) Cascade Pathway antibodies  Toll Like Receptor 4 (TLR4) Cascade Pathway Diagram
 Toll-Like Receptors Cascades Pathway antibodies  Toll-Like Receptors Cascades Pathway Diagram
Diseases associated with anti-LY86 antibodyOrgans/Tissues associated with anti-LY86 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >6 publications with LY86 and Inflammation
 Necrosis Antibodies  >3 publications with LY86 and Necrosis
 Cardiovascular Diseases Antibodies  >3 publications with LY86 and Cardiovascular Diseases
 Drug Toxicity Antibodies  >2 publications with LY86 and Drug Toxicity
 Weight Loss Antibodies  >2 publications with LY86 and Weight Loss
 Disease Models, Animal Antibodies  >2 publications with LY86 and Disease Models, Animal
 Pregnancy Complications Antibodies  >1 publications with LY86 and Pregnancy Complications
 Atherosclerosis Antibodies  >1 publications with LY86 and Atherosclerosis
 Fatty Liver Antibodies  >1 publications with LY86 and Fatty Liver
 Kidney Diseases Antibodies  >1 publications with LY86 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >6 publications with LY86 and Spleen
 Vascular Antibodies  >2 publications with LY86 and Vascular
 Lymph Node Antibodies  >2 publications with LY86 and Lymph Node
 Placenta Antibodies  >1 publications with LY86 and Placenta
 Intestine Antibodies  >1 publications with LY86 and Intestine
 Pharynx Antibodies  >1 publications with LY86 and Pharynx
 Bone Marrow Antibodies  >1 publications with LY86 and Bone Marrow
 Lung Antibodies  >1 publications with LY86 and Lung
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions