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anti-LTbR antibody :: Rabbit anti-Human Lymphotoxin Beta Receptor (LTbR) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2005935 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $165 +1 FREE 8GB USB
0.1 mg  /  $210 +1 FREE 8GB USB
0.2 mg  /  $310 +1 FREE 8GB USB
1 mg  /  $725 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Lymphotoxin Beta Receptor (LTbR), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Lymphotoxin Beta Receptor (LTbR)

 Product Gene Name   

anti-LTbR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG S-TYVSA KCSRIRDTVC ATCAENSYNE HWNYLTICQL CRPCDPVMGL EEIAPCTSKR KTQCRCQPGM FCAAWALECT HCELLSDCPP GTEAELKDEV GKGNNHCVPC KAGHFQNTSS PSARCQPHTR CENQGLVEAA PGTAQSDTTC KNPLE
 OMIM    L04270 mRNA
 3D Structure    ModBase 3D Structure for P36941
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against LTbR. It has been selected for its ability to recognize LTbR in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Recombinant LTbR (Thr66~Glu215) expressed in E.coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2042906
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-LTbR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-LTbR antibody    Knock-Out Validation Antibody
 Applications Tested/Suitable for anti-LTbR antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-LTbR antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) Knockout Verification of anti-LTbR antibody    Knockout Verification: Lane 1: Wild-type U87MG cell lysate; Lane 2: LTbR knockout U87MG cell lysate; Predicted MW: 45,47kDa Observed MW: 47kDa Primary Ab: 3ug/ml Rabbit Anti-Human LTbR Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
anti-LTbR antibody Western Blot (WB) Knockout Verification (WB) image
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 Western Blot (WB) of anti-LTbR antibody    Western Blot; Sample: Human U-87MG Cells.
anti-LTbR antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-LTbR antibody    Western Blot; Sample: Recombinant LTbR, Human.
anti-LTbR antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-LTbR antibody    DAB staining on IHC-P; Samples: Human Prostate Gland Tissue.
anti-LTbR antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-LTbR antibody    DAB staining on IHC-P; Samples: Human Liver Tissue
anti-LTbR antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-LTbR antibody    DAB staining on IHC-P; Samples: Human Rectum Cancer Tissue
anti-LTbR antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-LTbR antibody    DAB staining on IHC-P; Samples: Human Breast Cancer Tissue
anti-LTbR antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for LTbR. It may not necessarily be applicable to this product.
 NCBI GI #    402534565
 NCBI GeneID    4055
 NCBI Accession #    NP_001257916.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001270987.1 [Other Products]
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 UniProt Primary Accession #    P36941 [Other Products]
 UniProt Secondary Accession #    B7Z1D2; D3DUR2; F5GXE7 [Other Products]
 UniProt Related Accession #    P36941 [Other Products]
 Molecular Weight    44,810 Da
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 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 3 isoform 2
 NCBI Official Synonym Full Names    lymphotoxin beta receptor
 NCBI Official Symbol    LTBR [Similar Products]
 NCBI Official Synonym Symbols   
CD18; TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 3
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 3
 UniProt Synonym Protein Names   
Lymphotoxin-beta receptor; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2-related protein; Tumor necrosis factor receptor type III; TNF-RIII; TNFR-III
 Protein Family    Tumor necrosis factor receptor superfamily
 UniProt Gene Name    LTBR [Similar Products]
 UniProt Synonym Gene Names    D12S370; TNFCR; TNFR3; TNFRSF3; TNF-RIII; TNFR-III [Similar Products]
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 NCBI Summary for LTbR    This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]
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 UniProt Comments for LTbR    LTBR: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: integral component of plasma membrane; plasma membrane

Molecular Function: identical protein binding; protein binding; tumor necrosis factor-activated receptor activity; ubiquitin protein ligase binding

Biological Process: apoptosis; immune response; inflammatory response; multicellular organism development; myeloid dendritic cell differentiation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of JNK cascade; regulation of cell proliferation; response to lipopolysaccharide; signal transduction; tumor necrosis factor-mediated signaling pathway; viral process
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 Research Articles on LTbR    1. membrane-bound lymphotoxin-beta receptor (LTbetaR) and CXC chemokine receptor 2 (CXCR2), is involved in type B EAE development
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-LTbR antibodyDiseases associated with anti-LTbR antibody
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >182 publications with LTbR and Necrosis
 Inflammation Antibodies  >41 publications with LTbR and Inflammation
 Disease Models, Animal Antibodies  >14 publications with LTbR and Disease Models, Animal
 Nervous System Diseases Antibodies  >13 publications with LTbR and Nervous System Diseases
 Carcinoma, Squamous Cell Antibodies  >10 publications with LTbR and Carcinoma, Squamous Cell
 Liver Diseases Antibodies  >6 publications with LTbR and Liver Diseases
 Breast Neoplasms Antibodies  >5 publications with LTbR and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >4 publications with LTbR and Neoplasms, Experimental
 Weight Loss Antibodies  >4 publications with LTbR and Weight Loss
 Cardiovascular Diseases Antibodies  >4 publications with LTbR and Cardiovascular Diseases
Organs/Tissues associated with anti-LTbR antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >102 publications with LTbR and Blood
 Lymph Node Antibodies  >68 publications with LTbR and Lymph Node
 Spleen Antibodies  >49 publications with LTbR and Spleen
 Bone Antibodies  >44 publications with LTbR and Bone
 Bone Marrow Antibodies  >27 publications with LTbR and Bone Marrow
 Thymus Antibodies  >21 publications with LTbR and Thymus
 Intestine Antibodies  >21 publications with LTbR and Intestine
 Embryonic Tissue Antibodies  >20 publications with LTbR and Embryonic Tissue
 Vascular Antibodies  >19 publications with LTbR and Vascular
 Liver Antibodies  >14 publications with LTbR and Liver
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