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anti-CSF1R antibody :: Rabbit M-CSF Receptor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS859977
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

M-CSF Receptor (CSF1R), Polyclonal Antibody

 Also Known As   

M-CSF Receptor (Phospho-Tyr809) Antibody

 Product Synonym Names    CD115; CSF-1-R; CSF1R; CSFMR; EC 2.7.10.1; FMS; Fms proto-oncogene; M-CSFR; Macrophage colony stimulating factor I receptor precursor; c-fms; kinase CSFR
 Product Gene Name   

anti-CSF1R antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 221820
 3D Structure    ModBase 3D Structure for P07333
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    M-CSF Receptor (Phospho-Tyr809) antibody detects endogenous levels of M-CSF Receptor only when phosphorylated at tyrosine 809.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human M-CSF Receptor around the phosphorylation site of tyrosine 809 (S-N-YP-V-V).
 All Sites    Human: Tyr809; Mouse: Tyr807; Rat: Tyr807
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-CSF1R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CSF1R antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-CSF1R antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CSF1R antibody    WB: 1:500~1:1000, ELISA: 1:1000
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 Testing Data of anti-CSF1R antibody    Western blot analysis of extracts from 293 cells, treated with LPS (100ng/ml, 30mins), using M-CSF Receptor (Phospho-Tyr809) antibody.
anti-CSF1R antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CSF1R. It may not necessarily be applicable to this product.
 NCBI GI #    569026720
 NCBI GeneID    1436
 NCBI Accession #    NP_001275634.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001288705.1 [Other Products]
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 UniProt Primary Accession #    P07333 [Other Products]
 UniProt Secondary Accession #    Q6LDW5; Q6LDY4; Q86VW7; B5A955; D3DQG2 [Other Products]
 UniProt Related Accession #    P07333 [Other Products]
 Molecular Weight    33,248 Da [Similar Products]
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 NCBI Official Full Name    macrophage colony-stimulating factor 1 receptor
 NCBI Official Synonym Full Names    colony stimulating factor 1 receptor
 NCBI Official Symbol    CSF1R [Similar Products]
 NCBI Official Synonym Symbols   
FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R
[Similar Products]
 NCBI Protein Information    macrophage colony-stimulating factor 1 receptor; CD115 antigen; CSF-1 receptor; FMS proto-oncogene; proto-oncogene c-Fms; macrophage colony stimulating factor I receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog
 UniProt Protein Name    Macrophage colony-stimulating factor 1 receptor
 UniProt Synonym Protein Names   
CSF-1 receptor (EC:2.7.10.1); CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD_antigen: CD115
 Protein Family    Macrophage colony-stimulating factor 1 receptor
 UniProt Gene Name    CSF1R [Similar Products]
 UniProt Synonym Gene Names    FMS; CSF-1-R; CSF-1R; M-CSF-R [Similar Products]
 UniProt Entry Name    CSF1R_HUMAN
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 NCBI Summary for CSF1R    The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
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 UniProt Comments for CSF1R    CSFR: an oncogenic tyrosine kinase receptor for CSF-1 (M-CSF). Drives growth and development of monocytes. Binding of CSF-1 induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins. There are at least five major tyrosine autophosphorylation sites. Two point mutations seen in 10-20% of patients with acute myeloid leukemia, chronic myelomonocytic leukemia or myelodysplasia. One mutation appears to be both somatic and germline, and disrupts Cbl binding and receptor turnover. v-fms lacks the Cbl binding site and causes feline leukemia. Mutations may also develop after chemotherapy for lymphoma. A distinct point mutation was found in some cases of hepatocellular carcinoma and related to increased expression, and another mutation was found in 2 of 40 patients with idiopathic myelofibrosis. Expression is elevated in breast tumors and cell lines, and expression in xenografts and transgenic mice has been correlated with xenograft growth and breast cancer development. Inhibitors: Ki-20227 and other Kit/PDGFR inhibitors.

Protein type: Oncoprotein; Kinase, protein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Protein kinase, TK; Membrane protein, integral; TK group; PDGFR family

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: macrophage colony stimulating factor receptor activity; protein homodimerization activity; cytokine binding; protein phosphatase binding; ATP binding

Biological Process: regulation of bone resorption; peptidyl-tyrosine phosphorylation; macrophage differentiation; phosphoinositide-mediated signaling; monocyte differentiation; multicellular organismal development; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; osteoclast differentiation; signal transduction; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of cell shape; cell proliferation; positive regulation of cell proliferation; ruffle organization and biogenesis; innate immune response; hemopoiesis; phosphatidylinositol metabolic process; positive regulation of protein amino acid phosphorylation; inflammatory response; intercellular junction maintenance; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration

Disease: Leukoencephalopathy, Diffuse Hereditary, With Spheroids
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Product References and Citations for anti-CSF1R antibody

   BC Gliniak, Mol. Biol. Cell, May 1992; 3: 535.
T Inaba, J. Biol. Chem., Mar 1992; 267: 5693 - 5699.
Shinya Suzu, Blood, Apr 2005; 105: 3230 - 3237.
Shin-ichi Murase, J. Neurosci., Dec 1998; 18: 10481.
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 Research Articles on CSF1R    1. CSF-1R mayact as a transcriptional regulator on proliferation-related genes in breast cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CSF1R antibodyPathways associated with anti-CSF1R antibody
 Reference Product  PubMed Publications
 CSF1 antibody  >91 publications with CSF1R and CSF1
 GRB2 antibody  >52 publications with CSF1R and GRB2
 CBL antibody  >39 publications with CSF1R and CBL
 MYB antibody  >20 publications with CSF1R and MYB
 TYROBP antibody  >14 publications with CSF1R and TYROBP
 IL34 antibody  >4 publications with CSF1R and IL34
 ITGB3 antibody  >3 publications with CSF1R and ITGB3
 RASA1 antibody  >1 publications with CSF1R and RASA1
 PIK3R1 antibody  >1 publications with CSF1R and PIK3R1
 SPI1 antibody  >1 publications with CSF1R and SPI1
 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Integrins In Angiogenesis Pathway antibodies  Integrins In Angiogenesis Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
Diseases associated with anti-CSF1R antibodyOrgans/Tissues associated with anti-CSF1R antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1276 publications with CSF1R and Necrosis
 Inflammation Antibodies  >714 publications with CSF1R and Inflammation
 Leukemia, Myeloid, Acute Antibodies  >376 publications with CSF1R and Leukemia, Myeloid, Acute
 Lung Diseases Antibodies  >298 publications with CSF1R and Lung Diseases
 Cardiovascular Diseases Antibodies  >170 publications with CSF1R and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >163 publications with CSF1R and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >159 publications with CSF1R and Breast Neoplasms
 Lymphoma Antibodies  >158 publications with CSF1R and Lymphoma
 Lung Neoplasms Antibodies  >77 publications with CSF1R and Lung Neoplasms
 Kidney Diseases Antibodies  >70 publications with CSF1R and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3162 publications with CSF1R and Blood
 Bone Antibodies  >1958 publications with CSF1R and Bone
 Bone Marrow Antibodies  >1431 publications with CSF1R and Bone Marrow
 Lung Antibodies  >418 publications with CSF1R and Lung
 Spleen Antibodies  >272 publications with CSF1R and Spleen
 Brain Antibodies  >246 publications with CSF1R and Brain
 Liver Antibodies  >203 publications with CSF1R and Liver
 Muscle Antibodies  >136 publications with CSF1R and Muscle
 Kidney Antibodies  >135 publications with CSF1R and Kidney
 Embryonic Tissue Antibodies  >129 publications with CSF1R and Embryonic Tissue
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