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anti-M-CSF antibody :: Rabbit M-CSF Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS223924
Unit / Price
0.1 mg  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

M-CSF, Polyclonal Antibody

 Also Known As   

RABBIT ANTI HUMAN M-CSF

 Product Gene Name   

anti-M-CSF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    120420
 3D Structure    ModBase 3D Structure for P09603
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
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 Form/Format    Purified
Purified IgG - lyophilised
 Concentration    IgG concentration 1.0mg/ml after reconstitution (lot specific)
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 Reconstitution    Reconstitute with 0.1ml distilled water Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. For long term storage the addition of 0.09% sodium azide is recommended. N.B. For functional studies do not add sodium azide
 Immunogen    Recombinant human M-CSF
Buffer Solution
 Antiserum Preparation    Antiserum to human M-CSF were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
 Target Species    Human
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
 Other Notes    Small volumes of anti-M-CSF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-M-CSF antibody

   Rabbit anti Human M-CSF antibody specifically recognizes human M-CSF (Macrophage colony-stimulating factor), a potent lineage restricted haematopoietic growth factor and member of the CSF family of hormone-like glycoproteins, which plays a key role in the regulation of cellular differentiation, proliferation, and the survival of blood monocytes, tissue macrophages and their progenitor cells. Along with sRANKL/CD254/OPGL, M-CSF is essential for osteoclastogenesis, acting through the tyrosine kinase receptor c-fms (colony stimulating factor 1 receptor), and facilitates haematopoietic recovery following bone marrow transplantation.
 Applications Tested/Suitable for anti-M-CSF antibody   

ELISA (EIA), Functional Assays (FN), Immunohistology Paraffin*, Western Blot (WB)

 Application Notes for anti-M-CSF antibody    ELISA: Minimum Dilution: 0.5; Maximum Dilution: 2.0ug/ml;
Functional Assays: Minimum Dilution: 0.02; Maximum Dilution: 0.03ug/ml;
Immunohistology - Paraffin: Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml
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 Testing Data #1 of anti-M-CSF antibody    Formalin fixed, paraffin embedded human cervical squamous cell carcinoma stained with Rabbit anti Human M-CSF (MBS223924) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
anti-M-CSF antibody Testing Data #1 image
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 Testing Data #2 of anti-M-CSF antibody    Formalin fixed, paraffin embedded human cervical squamous cell carcinoma stained with Rabbit anti Human M-CSF (MBS223924) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
anti-M-CSF antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for M-CSF. It may not necessarily be applicable to this product.
 NCBI GI #    27262661
 NCBI GeneID    1435
 NCBI Accession #    NP_000748.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000757.5 [Other Products]
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 UniProt Primary Accession #    P09603 [Other Products]
 UniProt Secondary Accession #    Q13130; Q14086; Q14806; Q5VVF3; Q5VVF4; Q9UQR8; A8K6J5 [Other Products]
 UniProt Related Accession #    P09603 [Other Products]
 Molecular Weight    29,215 Da
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 NCBI Official Full Name    macrophage colony-stimulating factor 1 isoform a
 NCBI Official Synonym Full Names    colony stimulating factor 1 (macrophage)
 NCBI Official Symbol    CSF1 [Similar Products]
 NCBI Official Synonym Symbols   
MCSF; CSF-1
[Similar Products]
 NCBI Protein Information    macrophage colony-stimulating factor 1; lanimostim
 UniProt Protein Name    Macrophage colony-stimulating factor 1
 UniProt Synonym Protein Names   
LanimostimProcessed macrophage colony-stimulating factor 1
 UniProt Gene Name    CSF1 [Similar Products]
 UniProt Synonym Gene Names    CSF-1; M-CSF; MCSF [Similar Products]
 UniProt Entry Name    CSF1_HUMAN
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 NCBI Summary for M-CSF    The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
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 UniProt Comments for M-CSF    M-CSF: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers. Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: extracellular space; membrane; perinuclear region of cytoplasm; integral to membrane; plasma membrane; receptor complex

Molecular Function: protein homodimerization activity; growth factor activity; cytokine activity; macrophage colony stimulating factor receptor binding

Biological Process: positive regulation of monocyte differentiation; ossification; macrophage differentiation; positive regulation of osteoclast differentiation; positive regulation of cellular protein metabolic process; reproductive developmental process; positive regulation of odontogenesis of dentine-containing teeth; positive regulation of multicellular organism growth; osteoclast differentiation; odontogenesis; cell proliferation; positive regulation of mononuclear cell proliferation; monocyte activation; homeostasis of number of cells within a tissue; positive regulation of protein kinase activity; positive regulation of cell proliferation; innate immune response; hemopoiesis; positive regulation of Ras protein signal transduction; cell differentiation; positive regulation of cell-matrix adhesion; positive regulation of macrophage differentiation; regulation of ossification; inflammatory response; positive regulation of cell migration
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 Research Articles on M-CSF    1. potent profibrotic factor in hepatitis C virus liver fibrosis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-M-CSF antibodyPathways associated with anti-M-CSF antibody
 Reference Product  PubMed Publications
 CSF1R antibody  >93 publications with M-CSF and CSF1R
 JUN antibody  >22 publications with M-CSF and JUN
 GAPDH antibody  >3 publications with M-CSF and GAPDH
 MYC antibody  >3 publications with M-CSF and MYC
 ITGB3 antibody  >1 publications with M-CSF and ITGB3
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Integrins In Angiogenesis Pathway antibodies  Integrins In Angiogenesis Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
Diseases associated with anti-M-CSF antibodyOrgans/Tissues associated with anti-M-CSF antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >38 publications with M-CSF and Inflammation
 Carcinoma Antibodies  >26 publications with M-CSF and Carcinoma
 Breast Neoplasms Antibodies  >21 publications with M-CSF and Breast Neoplasms
 Necrosis Antibodies  >20 publications with M-CSF and Necrosis
 Adenocarcinoma Antibodies  >14 publications with M-CSF and Adenocarcinoma
 Lung Neoplasms Antibodies  >14 publications with M-CSF and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >10 publications with M-CSF and Neoplasms, Experimental
 Lung Diseases Antibodies  >9 publications with M-CSF and Lung Diseases
 Liver Diseases Antibodies  >7 publications with M-CSF and Liver Diseases
 Osteitis Deformans Antibodies  >6 publications with M-CSF and Osteitis Deformans
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >70 publications with M-CSF and Blood
 Bone Antibodies  >60 publications with M-CSF and Bone
 Lung Antibodies  >28 publications with M-CSF and Lung
 Liver Antibodies  >18 publications with M-CSF and Liver
 Brain Antibodies  >16 publications with M-CSF and Brain
 Connective Tissue Antibodies  >13 publications with M-CSF and Connective Tissue
 Lymph Node Antibodies  >12 publications with M-CSF and Lymph Node
 Intestine Antibodies  >10 publications with M-CSF and Intestine
 Kidney Antibodies  >10 publications with M-CSF and Kidney
 Spleen Antibodies  >9 publications with M-CSF and Spleen
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