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anti-M-CSF antibody :: Rabbit anti-Human M-CSF Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2536603
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

M-CSF, Polyclonal Antibody

★Popular Item★
 Also Known As   

M-CSF Polyclonal Antibody

 Product Synonym Names    CSF1; Macrophage colony-stimulating factor 1; CSF-1; M-CSF; MCSF; Lanimostim
 Product Gene Name   

anti-M-CSF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from the C-terminal region of human M-CSF.
 Buffer    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-M-CSF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-M-CSF antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-M-CSF antibody    WB: 1:500-1:2000, ELISA: 1:5000-1:20000
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 Western Blot (WB) of anti-M-CSF antibody    Western Blot analysis of 3T3 cells with M-CSF Polyclonal Antibody.
anti-M-CSF antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-M-CSF antibody    Immunohistochemistry of paraffin-embedded Human kidney tissue using M-CSF Polyclonal Antibody at dilution of 1:100.
anti-M-CSF antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for M-CSF. It may not necessarily be applicable to this product.
 NCBI GI #    57163771
 NCBI GeneID    493706
 NCBI Accession #    NP_001009231.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001009231.1 [Other Products]
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 UniProt Related Accession #    P13369 [Other Products]
 Molecular Weight    Calculated MW: 60
Observed MW: 48
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 NCBI Official Full Name    macrophage colony-stimulating factor 1 receptor
 NCBI Official Symbol    CSF1R [Similar Products]
 NCBI Official Synonym Symbols   
CSF1; M-CSF; CSF-1R; M-CSF-R
[Similar Products]
 NCBI Protein Information    macrophage colony-stimulating factor 1 receptor
 UniProt Protein Name    Macrophage colony-stimulating factor 1 receptor
 UniProt Synonym Protein Names   
CSF-1 receptor (EC:2.7.10.1); CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD_antigen: CD115
 UniProt Gene Name    CSF1R [Similar Products]
 UniProt Synonym Gene Names    FMS; CSF-1-R; CSF-1R; M-CSF-R [Similar Products]
 UniProt Entry Name    CSF1R_FELCA
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 UniProt Comments for M-CSF    Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor ().
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 Research Articles on M-CSF    1. the feline CSF-1R was cloned and the responsiveness to CSF-1 and IL-34 from a range of species, was examined.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-M-CSF antibodyPathways associated with anti-M-CSF antibody
 Reference Product  PubMed Publications
 CSF1 antibody  >115 publications with M-CSF and CSF1
 GRB2 antibody  >53 publications with M-CSF and GRB2
 CBL antibody  >41 publications with M-CSF and CBL
 SHC1 antibody  >15 publications with M-CSF and SHC1
 VEGFA antibody  >9 publications with M-CSF and VEGFA
 SPI1 antibody  >2 publications with M-CSF and SPI1
 CBLB antibody  >1 publications with M-CSF and CBLB
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
Diseases associated with anti-M-CSF antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1331 publications with M-CSF and Necrosis
 Inflammation Antibodies  >821 publications with M-CSF and Inflammation
 Leukemia, Myeloid, Acute Antibodies  >386 publications with M-CSF and Leukemia, Myeloid, Acute
 Lung Diseases Antibodies  >330 publications with M-CSF and Lung Diseases
 Breast Neoplasms Antibodies  >183 publications with M-CSF and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >182 publications with M-CSF and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >172 publications with M-CSF and Neoplasms, Experimental
 Atherosclerosis Antibodies  >99 publications with M-CSF and Atherosclerosis
 Lung Neoplasms Antibodies  >90 publications with M-CSF and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >80 publications with M-CSF and Neoplasm Metastasis
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